Results 21 to 30 of about 3,125,604 (306)

An energy metabolism-based eight-gene signature correlates with the clinical outcome of esophagus carcinoma

BMC Cancer, 2021
Background The essence of energy metabolism has spread to the field of esophageal cancer (ESC) cells. Herein, we tried to develop a prognostic prediction model for patients with ESC based on the expression profiles of energy metabolism associated genes ...
Weifeng Zheng, Chaoying Chen, Jianghao Yu, Chengfeng Jin, Tiemei Han   +4 more
doaj   +1 more source

Human Cancer Cells Express Slug-based Epithelial-Mesenchymal Transition Gene Signature Obtained in Vivo [PDF]

, 2011
The biological mechanisms underlying cancer cell motility and invasiveness remain unclear, although it has been hypothesized that they involve some type of epithelial-mesenchymal transition (EMT).
Rumjantseva Viktoria, Cheng Weiyi, Viktoria Rumjantseva, Kandel Jessica J, Jessica J Kandel, Yamashiro, Darrell, Jianzhong Huang, Peter D. Canoll, Huang, Jianzhong, Dimitris Anastassiou, Anastassiou Dimitris, Darrell J Yamashiro, Yamashiro Darrell J, Canoll Peter D, Canoll, Peter D., Kandel, Jessica J., Wei-yi Cheng, Rumjantseva, Viktoria, Huang Jianzhong, Jessica J. Kandel, Cheng, Weiyi, Darrell J. Yamashiro, Weiyi Cheng, Anastassiou, Dimitris, Peter D Canoll   +24 more
core   +2 more sources

Gene Signatures Revisited [PDF]

JNCI Journal of the National Cancer Institute, 2012
The three-gene model of Haibe-Kains et al. (1) in this issue of the Journal continues a recent trend (2–4) in which a gene signature with only a few genes classifies cancer specimens as well or better than signatures with many more genes. Given that cancer cells involve large numbers of genetic mutations (5), why should a signature with only few genes ...
openaire   +2 more sources

Identification of a six-gene signature predicting overall survival for hepatocellular carcinoma

Cancer Cell International, 2019
Background Hepatocellular carcinoma (HCC) remains a major challenge for public health worldwide. Considering the great heterogeneity of HCC, more accurate prognostic models are urgently needed.
Gao-Min Liu, Hua-Dong Zeng, Cai-Yun Zhang, Ji-Wei Xu   +3 more
doaj   +1 more source

Construction and validation of a seven-gene signature for predicting overall survival in patients with kidney renal clear cell carcinoma via an integrated bioinformatics analysis

Animal Cells and Systems, 2020
Kidney renal clear cell carcinoma (KIRC) remains a significant challenge worldwide because of its poor prognosis and high mortality rate, and accurate prognostic gene signatures are urgently required for individual therapy.
Huiming Jiang, Haibin Chen, Nanhui Chen
doaj   +1 more source

Identification of a novel six‐gene signature with potential prognostic and therapeutic value in cervical cancer

Cancer Medicine, 2021
Introduction Cervical cancer has high mortality, high recurrence and poor prognosis. Although prognostic biomarkers such as clinicopathological features have been proposed, their accuracy and precision are far from satisfactory.
Xinyu Qu, Zhiwen Shi, Jingjing Guo, Chenyan Guo, Junjun Qiu, Keqin Hua   +5 more
doaj   +1 more source

Prognostic Signatures of Metabolic Genes and Metabolism-Related Long Non-coding RNAs Accurately Predict Overall Survival for Osteosarcoma Patients

Frontiers in Cell and Developmental Biology, 2021
In this study, we identified eight survival-related metabolic genes in differentially expressed metabolic genes by univariate Cox regression analysis based on the therapeutically applicable research to generate effective treatments (n = 84) data set and ...
Gong Chao-yang, Gong Chao-yang, Tang Rong, Shi Yong-qiang, Shi Yong-qiang, Liu Tai-cong, Liu Tai-cong, Zhou Kai-sheng, Nan Wei, Zhang Hai-hong   +9 more
doaj   +1 more source

A robust six-gene prognostic signature for prediction of both disease-free and overall survival in non-small cell lung cancer

Journal of Translational Medicine, 2019
Background The high mortality of patients with non-small cell lung cancer (NSCLC) emphasizes the necessity of identifying a robust and reliable prognostic signature for NSCLC patients.
Shuguang Zuo, Min Wei, Hailin Zhang, Anxian Chen, Junhua Wu, Jiwu Wei, Jie Dong   +6 more
doaj   +1 more source

Identification of a Four-Gene-Based SERM Signature for Prognostic and Drug Sensitivity Prediction in Gastric Cancer

Frontiers in Oncology, 2022
BackgroundGastric cancer (GC) is a highly molecular heterogeneous tumor with poor prognosis. Epithelial-mesenchymal transition (EMT) process and cancer stem cells (CSCs) are reported to share common signaling pathways and cause poor prognosis in GC ...
Xiya Jia, Xiya Jia, Bing Chen, Bing Chen, Ziteng Li, Ziteng Li, Shenglin Huang, Shenglin Huang, Siyuan Chen, Siyuan Chen, Runye Zhou, Runye Zhou, Wanjing Feng, Wanjing Feng, Hui Zhu, Hui Zhu, Xiaodong Zhu, Xiaodong Zhu   +17 more
doaj   +1 more source

An Immune-Gene-Based Classifier Predicts Prognosis in Patients With Cervical Squamous Cell Carcinoma

Frontiers in Molecular Biosciences, 2021
Objective: Immunity plays a vital role in the human papilloma virus (HPV) persistent infection, and closely associates with occurrence and development of cervical squamous cell carcinoma (CSCC).
Huixia Yang, Xiaoyan Han, Zengping Hao
doaj   +1 more source