Results 21 to 30 of about 320,196 (265)

A robust six-gene prognostic signature for prediction of both disease-free and overall survival in non-small cell lung cancer

Journal of Translational Medicine, 2019
Background The high mortality of patients with non-small cell lung cancer (NSCLC) emphasizes the necessity of identifying a robust and reliable prognostic signature for NSCLC patients.
Shuguang Zuo, Min Wei, Hailin Zhang, Anxian Chen, Junhua Wu, Jiwu Wei, Jie Dong   +6 more
doaj   +1 more source

Construction and validation of a seven-gene signature for predicting overall survival in patients with kidney renal clear cell carcinoma via an integrated bioinformatics analysis

Animal Cells and Systems, 2020
Kidney renal clear cell carcinoma (KIRC) remains a significant challenge worldwide because of its poor prognosis and high mortality rate, and accurate prognostic gene signatures are urgently required for individual therapy.
Huiming Jiang, Haibin Chen, Nanhui Chen
doaj   +1 more source

Identification of a novel six‐gene signature with potential prognostic and therapeutic value in cervical cancer

Cancer Medicine, 2021
Introduction Cervical cancer has high mortality, high recurrence and poor prognosis. Although prognostic biomarkers such as clinicopathological features have been proposed, their accuracy and precision are far from satisfactory.
Xinyu Qu, Zhiwen Shi, Jingjing Guo, Chenyan Guo, Junjun Qiu, Keqin Hua   +5 more
doaj   +1 more source

Prognostic Signatures of Metabolic Genes and Metabolism-Related Long Non-coding RNAs Accurately Predict Overall Survival for Osteosarcoma Patients

Frontiers in Cell and Developmental Biology, 2021
In this study, we identified eight survival-related metabolic genes in differentially expressed metabolic genes by univariate Cox regression analysis based on the therapeutically applicable research to generate effective treatments (n = 84) data set and ...
Gong Chao-yang, Gong Chao-yang, Tang Rong, Shi Yong-qiang, Shi Yong-qiang, Liu Tai-cong, Liu Tai-cong, Zhou Kai-sheng, Nan Wei, Zhang Hai-hong   +9 more
doaj   +1 more source

Identification of a six-gene signature predicting overall survival for hepatocellular carcinoma

Cancer Cell International, 2019
Background Hepatocellular carcinoma (HCC) remains a major challenge for public health worldwide. Considering the great heterogeneity of HCC, more accurate prognostic models are urgently needed.
Gao-Min Liu, Hua-Dong Zeng, Cai-Yun Zhang, Ji-Wei Xu   +3 more
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Identification of a Four-Gene-Based SERM Signature for Prognostic and Drug Sensitivity Prediction in Gastric Cancer

Frontiers in Oncology, 2022
BackgroundGastric cancer (GC) is a highly molecular heterogeneous tumor with poor prognosis. Epithelial-mesenchymal transition (EMT) process and cancer stem cells (CSCs) are reported to share common signaling pathways and cause poor prognosis in GC ...
Xiya Jia, Xiya Jia, Bing Chen, Bing Chen, Ziteng Li, Ziteng Li, Shenglin Huang, Shenglin Huang, Siyuan Chen, Siyuan Chen, Runye Zhou, Runye Zhou, Wanjing Feng, Wanjing Feng, Hui Zhu, Hui Zhu, Xiaodong Zhu, Xiaodong Zhu   +17 more
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An Immune-Gene-Based Classifier Predicts Prognosis in Patients With Cervical Squamous Cell Carcinoma

Frontiers in Molecular Biosciences, 2021
Objective: Immunity plays a vital role in the human papilloma virus (HPV) persistent infection, and closely associates with occurrence and development of cervical squamous cell carcinoma (CSCC).
Huixia Yang, Xiaoyan Han, Zengping Hao
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Identification of autoimmune gene signatures in autism [PDF]

Translational Psychiatry, 2011
The role of the immune system in neuropsychiatric diseases, including autism spectrum disorder (ASD), has long been hypothesized. This hypothesis has mainly been supported by family cohort studies and the immunological abnormalities found in ASD patients, but had limited findings in genetic association testing.
Jung, J-Y, Kohane, Isaac, Wall, Dennis Paul   +2 more
openaire   +4 more sources

Association between changes in gene signatures expression and disease activity among patients with systemic lupus erythematosus

BMC Medical Genomics, 2019
Background We assessed the stability of BAFF, interferon, plasma cell and LDG neutrophil gene expression signatures over time, and whether changes in expression coincided with changes in SLE disease activity. Methods Two hundred forty-three patients with
Michelle Petri, Wei Fu, Ann Ranger, Norm Allaire, Patrick Cullen, Laurence S. Magder, Yuji Zhang   +6 more
doaj   +1 more source

A comparison of curated gene sets versus transcriptomics-derived gene signatures for detecting pathway activation in immune cells

BMC Bioinformatics, 2020
Background Despite the significant contribution of transcriptomics to the fields of biological and biomedical research, interpreting long lists of significantly differentially expressed genes remains a challenging step in the analysis process.
Bin Liu, Patrick Lindner, Adan Chari Jirmo, Ulrich Maus, Thomas Illig, David S. DeLuca   +5 more
doaj   +1 more source