Tumor-stroma derived gene expression patterns as prognosticators in breast cancer [PDF]
, 2010 The stroma, which embeds epithelial cells, plays a major role in the shaping and physiological regulation of animal organs such as the breast. Aberrant functioning of the stroma was found to support tumorigenesis and cancer progression.
Rajski, Michal
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A Gene Signature Derived from the Loss of CDKN1A (p21) Is Associated with CMS4 Colorectal Cancer [PDF]
, 2021 The epithelial–mesenchymal transition (EMT) is associated with tumor aggressiveness and increased invasion, migration, metastasis, angiogenesis, and drug resistance.
Bäuerle, Tobias +29 more
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Identification of autoimmune gene signatures in autism [PDF]
Translational Psychiatry, 2011 The role of the immune system in neuropsychiatric diseases, including autism spectrum disorder (ASD), has long been hypothesized. This hypothesis has mainly been supported by family cohort studies and the immunological abnormalities found in ASD patients, but had limited findings in genetic association testing.
Jung, J-Y +2 more
openaire +4 more sources
A gene signature for post-infectious chronic fatigue syndrome [PDF]
, 2009 Background: At present, there are no clinically reliable disease markers for chronic fatigue syndrome. DNA chip microarray technology provides a method for examining the differential expression of mRNA from a large number of genes.
Gow John W +23 more
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Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes [PDF]
, 2012 Mutations in the TP53 gene are very common in human cancers, and are associated with poor clinical outcome. Transgenic mouse models lacking the Trp53 gene or that express mutant Trp53 transgenes produce tumours with malignant features in many organs.
Miquel Taron +64 more
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BMC Medical Genomics, 2019 Background We assessed the stability of BAFF, interferon, plasma cell and LDG neutrophil gene expression signatures over time, and whether changes in expression coincided with changes in SLE disease activity. Methods Two hundred forty-three patients with
Michelle Petri +6 more
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Homogeneous datasets of triple negative breast cancers enable the identification of novel prognostic and predictive signatures [PDF]
, 2011 Background: Current prognostic gene signatures for breast cancer mainly reflect proliferation status and have limited value in triple-negative (TNBC) cancers.
Pusztai, Lajos +44 more
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BMC Bioinformatics, 2020 Background Despite the significant contribution of transcriptomics to the fields of biological and biomedical research, interpreting long lists of significantly differentially expressed genes remains a challenging step in the analysis process.
Bin Liu +5 more
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Soft sweeps III: The signature of positive selection from recurrent mutation [PDF]
, 2006 Polymorphism data can be used to identify loci at which a beneficial allele has recently gone to fixation, given that an accurate description of the signature of selection is available. In the classical model that is used, a favored allele derives from a
Pleuni S. Pennings +4 more
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Signature of arylacetamide deacetylase expression is associated with prognosis and immune infiltration in ovarian cancer [PDF]
Obstetrics & Gynecology Science, 2022 Objective The role of the protein-coding gene arylacetamide deacetylase (AADAC) in the prognostication of ovarian cancer remains uncertain. We aimed to identify and validate its prognostic value using integrated bioinformatics analyses.
Jianyang Feng, Hong He
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