Results 11 to 20 of about 320,196 (265)
Frontiers in Genetics, 2020 BackgroundBladder carcinoma (BC) is one of the most prevalent and malignant tumors. Multiple gene signatures based on BC metabolism, especially regarding glycolysis, remain unclear. Thus, we developed a glycolysis-related gene signature to be used for BC
Zezhong Mou +21 more
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A novel pyroptosis-associated gene signature for immune status and prognosis of cutaneous melanoma [PDF]
PeerJ, 2021 Background Cutaneous melanoma (CM) is a life-threatening destructive malignancy. Pyroptosis significantly correlates with programmed tumor cell death and its microenvironment through active host-tumor crosstalk.
Zhengyuan Wu +5 more
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Detecting signatures of selection on gene expression [PDF]
Nature Ecology & Evolution, 2022 A substantial amount of phenotypic diversity results from changes in gene expression levels and patterns. Understanding how the transcriptome evolves is therefore a key priority in identifying mechanisms of adaptive change. However, in contrast to powerful models of sequence evolution, we lack a consensus model of gene expression evolution. Furthermore,
Peter D. Price +8 more
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Frontiers in Cell and Developmental Biology, 2021 Background: Cancer-associated fibroblasts (CAFs) are mainly involved in cancer progression and treatment failure. However, the specific signature of CAFs and their related clinicopathological parameters in renal cell carcinoma (RCC) remain unclear. Here,
Bitian Liu +4 more
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Gene signature of the embryonic meniscus [PDF]
Journal of Orthopaedic Research, 2013 ABSTRACTThe meniscus is a fibrocartilagenous disc in the knee that protects the joint from damage. Meniscal injuries are common, however repair efforts are largely unsuccessful and are not able to prevent the degenerative changes that result in development of osteoarthritis.
Dorothy E, Pazin +4 more
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BMC Cancer, 2021 Background The essence of energy metabolism has spread to the field of esophageal cancer (ESC) cells. Herein, we tried to develop a prognostic prediction model for patients with ESC based on the expression profiles of energy metabolism associated genes ...
Weifeng Zheng +4 more
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Genes and Diseases, 2022 Emerging evidence suggests that peroxisomes play a role in the regulation of tumorigenesis and cancer progression. However, the prognostic value of peroxisome-related genes has been rarely investigated.
Liewang Qiu +4 more
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Frontiers in Genetics, 2020 Malignant pleural mesothelioma (MPM), predominantly caused by asbestos exposure, is a highly aggressive cancer with poor prognosis. The staging systems currently used in clinics is inadequate in evaluating the prognosis of MPM. In this study, a five-gene
Yiyang Bai +9 more
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An 18-gene signature for vascular invasion is associated with aggressive features and reduced survival in breast cancer. [PDF]
PLoS ONE, 2014 AIMS: Vascular invasion by tumor cells is known to be important for cancer progression. By microarray and qPCR analyses, we earlier identified an 18-gene signature associated with vascular involvement in endometrial cancer.
Monica Mannelqvist +3 more
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Gene Signatures Revisited [PDF]
JNCI Journal of the National Cancer Institute, 2012 The three-gene model of Haibe-Kains et al. (1) in this issue of the Journal continues a recent trend (2–4) in which a gene signature with only a few genes classifies cancer specimens as well or better than signatures with many more genes. Given that cancer cells involve large numbers of genetic mutations (5), why should a signature with only few genes ...
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