Results 11 to 20 of about 3,125,604 (306)
SIGNATURE: A workbench for gene expression signature analysis [PDF]
BMC Bioinformatics, 2011 Background The biological phenotype of a cell, such as a characteristic visual image or behavior, reflects activities derived from the expression of collections of genes.
Chang Jeffrey T +5 more
doaj +3 more sources
Gene expression analysis by signature pyrosequencing
Gene, 2002 We describe a novel method for transcript profiling based on high-throughput parallel sequencing of signature tags using a non-gel-based microtiter plate format.
Holmberg, Anders, +8 more
core +3 more sources
A gene expression signature for insulin resistance
Physiological Genomics, 2011 Insulin resistance is a heterogeneous disorder caused by a range of genetic and environmental factors, and we hypothesize that its etiology varies considerably between individuals.
Foletta, Victoria C. +39 more
core +4 more sources
Signature Genes as a Phylogenomic Tool [PDF]
Molecular Biology and Evolution, 2008 Gene content has been shown to contain a strong phylogenetic signal, yet its usage for phylogenetic questions is hampered by horizontal gene transfer and parallel gene loss and until now required completely sequenced genomes. Here, we introduce an approach that allows the phylogenetic signal in gene content to be applied to any set of sequences, using ...
Dutilh, B.E. +3 more
openaire +5 more sources
A novel pyroptosis-associated gene signature for immune status and prognosis of cutaneous melanoma [PDF]
PeerJ, 2021 Background Cutaneous melanoma (CM) is a life-threatening destructive malignancy. Pyroptosis significantly correlates with programmed tumor cell death and its microenvironment through active host-tumor crosstalk.
Zhengyuan Wu +5 more
doaj +2 more sources
Gene signature of the embryonic meniscus [PDF]
Journal of Orthopaedic Research, 2013 ABSTRACTThe meniscus is a fibrocartilagenous disc in the knee that protects the joint from damage. Meniscal injuries are common, however repair efforts are largely unsuccessful and are not able to prevent the degenerative changes that result in development of osteoarthritis.
Dorothy E, Pazin +4 more
openaire +2 more sources
Detecting signatures of selection on gene expression [PDF]
Nature Ecology & Evolution, 2022 A substantial amount of phenotypic diversity results from changes in gene expression levels and patterns. Understanding how the transcriptome evolves is therefore a key priority in identifying mechanisms of adaptive change. However, in contrast to powerful models of sequence evolution, we lack a consensus model of gene expression evolution. Furthermore,
Peter D. Price +8 more
openaire +4 more sources
Frontiers in Genetics, 2020 Malignant pleural mesothelioma (MPM), predominantly caused by asbestos exposure, is a highly aggressive cancer with poor prognosis. The staging systems currently used in clinics is inadequate in evaluating the prognosis of MPM. In this study, a five-gene
Yiyang Bai +9 more
doaj +1 more source
An 18-gene signature for vascular invasion is associated with aggressive features and reduced survival in breast cancer. [PDF]
PLoS ONE, 2014 AIMS: Vascular invasion by tumor cells is known to be important for cancer progression. By microarray and qPCR analyses, we earlier identified an 18-gene signature associated with vascular involvement in endometrial cancer.
Monica Mannelqvist +3 more
doaj +1 more source
Genes and Diseases, 2022 Emerging evidence suggests that peroxisomes play a role in the regulation of tumorigenesis and cancer progression. However, the prognostic value of peroxisome-related genes has been rarely investigated.
Liewang Qiu +4 more
doaj +1 more source