Results 31 to 40 of about 2,378,169 (247)

Regulatory T cell proliferative potential as novel marker to investigate immune tolerance and clinical progression in Multiple Sclerosis [PDF]

, 2011
In autoimmune disorders such as Multiple Sclerosis (MS) one of the determining alteration is the breakdown of self-antigen immune-tolerance. Peripheral immune tolerance is maintained, at least in part, by Regulatory T cells (Treg).
Carbone, Fortunata
core   +1 more source

Synergy in Immunostimulatory and Pro-Differentiation Effects of Vitamin D Analog and Fludarabine in Acute Myeloid Leukemias

Cells
Acute myeloid leukemia (AML) is an aggressive and often fatal hematopoietic malignancy, diagnosed predominantly in the elderly. The five-year survival of patients with AML is as low as 30%.
Subhradeep Haldar, Artem Petruk, Aleksandra Marchwicka, Andrzej Kutner, Monika Biernat, Dariusz Wołowiec, Ewa Marcinkowska   +6 more
doaj   +1 more source

Fold changes in gene expression upon immune stimulation.

, 2016
Fold changes in gene expression upon immune stimulation.
Heike Kliem (2839124), Claudia Flinspach (2839118), Maria Hillreiner (2839121), Michael W. Pfaffl (157580)   +3 more
core   +1 more source

Electrical Stimulation for Immune Modulation in Cancer Treatments

Frontiers in Bioengineering and Biotechnology, 2022
Immunotherapy is becoming a very common treatment for cancer, using approaches like checkpoint inhibition, T cell transfer therapy, monoclonal antibodies and cancer vaccination.
Ritopa Das, Sofia Langou, Thinh T. Le, Pooja Prasad, Feng Lin, Thanh D. Nguyen, Thanh D. Nguyen, Thanh D. Nguyen   +7 more
doaj   +1 more source

Structure Activity Relationships of α-L-LNA Modified Phosphorothioate Gapmer Antisense Oligonucleotides in Animals

Molecular Therapy: Nucleic Acids, 2012
We report the structure activity relationships of short 14-mer phosphorothioate gapmer antisense oligonucleotides (ASOs) modified with α-L-locked nucleic acid (LNA) and related modifications targeting phosphatase and tensin homologue (PTEN) messenger RNA
Punit P Seth, Ali Jazayeri, Jeff Yu, Charles R Allerson, Balkrishen Bhat, Eric E Swayze   +5 more
doaj   +1 more source

Immunomodulatory Effects of Bacterial Toll-like Receptor Ligands on the Phenotype and Function of Milk Immune Cells in Dromedary Camel

Biology, 2023
(1) Toll-like receptors (TLR) are a family of pattern recognition receptors that sense distinct molecular patterns of microbial origin. Although the immune cell composition of camel milk has been recently described, host–pathogen interaction studies in ...
Jamal Hussen, Mayyadah Abdullah Alkuwayti, Baraa Falemban, Mohammed Ali Al-Sukruwah, Sameer M. Alhojaily, Naser Abdallah Al Humam, Salma Al Adwani   +6 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Chitin modulates innate immune responses of keratinocytes. [PDF]

, 2011
Chitin, after cellulose the second most abundant polysaccharide in nature, is an essential component of exoskeletons of crabs, shrimps and insects and protects these organisms from harsh conditions in their environment.
Korting, Hans Christian, Koller, Barbara, Thomas Ruzicka, Korting Hans Christian, Rupec Rudolph, Müller-Wiefel Alisa Sophie, Alisa Sophie Müller-Wiefel, Müller-Wiefel, Alisa Sophie, Rudolph Rupec, Koller Barbara, Hans Christian Korting, Ruzicka, Thomas, Barbara Koller, Ruzicka Thomas, Rupec, Rudolph   +14 more
core   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Comparison of stimulation patterns for FES-cycling using measures of oxygen cost and stimulation cost [PDF]

, 2006
<b>Aim</b><p></p> The energy efficiency of FES-cycling in spinal cord injured subjects is very much lower than that of normal cycling, and efficiency is dependent upon the parameters of muscle stimulation.
Stone, B., Grant, S., Hunt, K.J., Fraser, M.H., Allen, D.B., Ferrario, C., McLean, A.N.   +6 more
core   +1 more source