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Prevalence and factors associated with adverse drug events among patients on dolutegravir-based regimen at the Immune Suppression Syndrome Clinic of Mbarara Regional Referral Hospital, Uganda: a mixed design study

AIDS Research and Therapy, 2022
Background In low income countries such as Uganda progress has been made towards achieving the United Nations AIDS programme 95-95-95 target however efforts are still impeded by pretreatment drug resistance and adverse drug events (ADEs) hence ...
Angella Namulindwa, John Hans Wasswa, Winnie Muyindike, Robert Tamukong, Joseph Oloro   +4 more
doaj   +1 more source

Reversing Post-Infectious Epigenetic-Mediated Immune Suppression

Frontiers in Immunology, 2021
The immune response must balance the pro-inflammatory, cell-mediated cytotoxicity with the anti-inflammatory and wound repair response. Epigenetic mechanisms mediate this balance and limit host immunity from inducing exuberant collateral damage to host ...
Abhimanyu, Carlos O. Ontiveros, Carlos O. Ontiveros, Rosa S. Guerra-Resendez, Tomoki Nishiguchi, Malik Ladki, Isaac B. Hilton, Isaac B. Hilton, Isaac B. Hilton, Larry S. Schlesinger, Andrew R. DiNardo   +10 more
doaj   +1 more source

Is an Immunosuppressive Microenvironment a Characteristic of Both Intra- and Extraparenchymal Central Nervous Tumors?

Pathophysiology, 2021
In spite of intensive research, the survival rates of patients diagnosed with tumors of the central nervous system (CNS) have not improved significantly in the last decade.
Amina Soltani, Bela Kajtar, El Husseiny Mohamed Mahmud Abdelwahab, Anita Steib, Zsolt Horvath, Laszlo Mangel, Luca Jaromi, Judit E. Pongracz   +7 more
doaj   +1 more source

Immune suppression in gliomas [PDF]

Journal of Neuro-Oncology, 2020
Abstract Introduction The overall survival in patients with gliomas has not significantly increased in the modern era, despite advances such as immunotherapy. This is in part due to their notorious ability to suppress local and systemic immune responses, severely restricting treatment efficacy.
Grabowski, Matthew M., Sankey, Eric W., Ryan, Katherine J., Chongsathidkiet, Pakawat, Lorrey, Selena J., Wilkinson, Daniel S., Fecci, Peter E.   +6 more
openaire   +2 more sources

Measles, One of the Re-emerging Diseases [PDF]

Journal of Microbiology and Infectious Diseases, 2016
Objective: The aim of the study is to stand out the measles which is a highly contagious re-emerging viral illness and may cause severe complications in susceptible population.
Zeynep Türe, Hayati Demiraslan, Tuğba Tok, Mehmet Doğanay   +3 more
doaj   +1 more source

Overlapping but Disparate Inflammatory and Immunosuppressive Responses to SARS-CoV-2 and Bacterial Sepsis: An Immunological Time Course Analysis

Frontiers in Immunology, 2021
Both severe SARS-CoV-2 infections and bacterial sepsis exhibit an immunological dyscrasia and propensity for secondary infections. The nature of the immunological dyscrasias for these differing etiologies and their time course remain unclear.
Tyler J. Loftus, Ricardo Ungaro, Marvin Dirain, Philip A. Efron, Monty B. Mazer, Kenneth E. Remy, Richard S. Hotchkiss, Luer Zhong, Rhonda Bacher, Petr Starostik, Lyle L. Moldawer, Scott C. Brakenridge   +11 more
doaj   +1 more source

Immune Suppression in Pregnancy and Cancer: Parallels and Insights

Translational Oncology, 2020
Immune system has evolved to maintain homeostatic balance between effector and regulatory immunity, which is critical to both elicit an adequate protective response to fight pathogens and disease, such as cancer, and to prevent damage to healthy tissues.
Irina Kareva
doaj   +1 more source

Recent advances in the mechanisms and treatment of immune thrombocytopenia

EBioMedicine, 2022
Summary: Primary immune thrombocytopenia is an autoimmune disease associated with a reduced peripheral blood platelet count. The phenotype is variable with some patients suffering no bleeding whilst others have severe bleeding which may be fatal ...
Drew Provan, John W. Semple
doaj   +1 more source

Role of the adaptive immune response in sepsis

Intensive Care Medicine Experimental, 2020
Sepsis is a syndrome of shock and dysfunction of multiple vital organs that is caused by an uncontrolled immune response to infection and has a high mortality rate. There are no therapies for sepsis, and it has become a global cause for concern. Advances
Jack Brady, Shahd Horie, John G. Laffey
doaj   +1 more source

Protective versus Pathogenic Type I Interferon Responses during Virus Infections

Viruses, 2023
Following virus infections, type I interferons are synthesized to induce the expression of antiviral molecules and interfere with virus replication. The importance of early antiviral type I IFN response against virus invasion has been emphasized during ...
Kwang Il Jung, Savannah McKenna, Vijayamahantesh Vijayamahantesh, Ying He, Bumsuk Hahm   +4 more
doaj   +1 more source