Results 11 to 20 of about 792,761 (305)

PI3Kγ is a molecular switch that controls immune suppression [PDF]

Nature, 2016
Macrophages play critical, but opposite, roles in acute and chronic inflammation and cancer1,2,3,4,5. In response to pathogens or injury, inflammatory macrophages express cytokines that stimulate cytotoxic T cells, whereas macrophages in neoplastic and ...
A Arranz, A Sica, Abraham V. Nguyen, AJ Gunderson, B Chaurasia, B Győrffy, B Ruffell, B Vanhaesebroeck, C Baer, CA Evans, Camila C. Figueiredo, Christopher J. Leem, David G. Winkler, EL Martin, Ezra E. W. Cohen, Gyunghwi Woo, Hongying Li, I Tabas, Jeffery Kutok, Judith A. Varner, Karen McGovern, Karen S. Messer, Kelly A. Frazer, M Martini, Matthew Rausch, MC Schmid, MC Schmid, MC Schmid, Megan M. Kaneda, Melissa Pink, Michael C. Schmid, Michael Karin, MJ Gray, MJ Rauh, MM Kaneda, N van Rooijen, Natacha Ralainirina, P Sharma, Philippe Foubert, Roman Sasik, S Yue, Sara Gorjestani, SL Topalian, SM Pyonteck, TA Wynn, V Byles, V Poli, Vito J. Palombella, Xuefeng Wu, Y Ben-Neriah   +49 more
core   +4 more sources

Can Immune Suppression and Epigenome Regulation in Placenta Offer Novel Insights into Cancer Immune Evasion and Immunotherapy Resistance?

Epigenomes, 2021
Cancer is the second leading cause of mortality and morbidity in the developed world. Cancer progression involves genetic and epigenetic alterations, accompanied by aggressive changes, such as increased immune evasion, onset of metastasis, and drug ...
Sultana Mehbuba Hossain, Chiemi F. Lynch-Sutherland, Aniruddha Chatterjee, Erin C. Macaulay, Michael R. Eccles   +4 more
doaj   +1 more source

Beyond the immune suppression: the immunotherapy in prostate cancer [PDF]

, 2015
Prostate cancer (PCa) is the second most common cancer in men.Aswell in many other human cancers, inflammation and immune suppression have an important role in their development.We briefly describe the host components that interact with the tumor to ...
Agliano', Anna Maria, Cattarino, Susanna, Collalti, Giulia, Sciarra, Alessandro, Silvestri, Ida   +4 more
core   +3 more sources

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards [PDF]

, 2016
Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both immune ...
Brandau, Sven, Bronte, Vincenzo, Chen, Shu Hsia, Colombo, Mario P, Frey, Alan B, Gabrilovich, Dmitry I., Greten, Tim F, Mandruzzato, Susanna, Murray, Peter J, Ochoa, Augusto, Ostrand Rosenberg, Suzanne, Rodriguez, Paulo C, Sica, Antonio, Umansky, Viktor, Vonderheide, Robert H   +14 more
core   +2 more sources

Efficacy of immune suppression tapering in treating relapse after reduced intensity allogeneic stem cell transplantation

Haematologica, 2015
For patients who relapse after allogeneic hematopoietic stem cell transplantation while still on immune suppression, there is anecdotal evidence that tapering the immune suppression may result in graft-versus-tumor activity.
Natasha Kekre, Haesook T. Kim, Gita Thanarajasingam, Philippe Armand, Joseph H. Antin, Corey Cutler, Sarah Nikiforow, Vincent T. Ho, John Koreth, Edwin P. Alyea, Robert J. Soiffer   +10 more
doaj   +1 more source

Expression and DNA methylation of TNF, IFNG and FOXP3 in colorectal cancer and their prognostic significance. [PDF]

, 2014
BACKGROUND: Colorectal cancer (CRC) progression is associated with suppression of host cell-mediated immunity and local immune escape mechanisms. Our aim was to assess the immune function in terms of expression of TNF, IFNG and FOXP3 in CRC. METHODS:
A D Beggs, A Merlo, AG Heriot, AM Wolf, C Evans, C Grunfeld, C Loddenkemper, CF Evans, D Kumar, DJ Needham, E Sato, F Balkwill, G Brandacher, G Galizia, G Pawelec, H Nakayama, IC Talbot, JC Harrison, JD Fontenot, JK Polansky, KE Sullivan, KJ Livak, KL Ling, L Xue, LA Liotta, LM Ebert, M Kanazawa, M Kim, M Morris, M Shibata, N Hiraoka, N Kobayashi, N Watanabe, P Quirke, P Radhakrishnan, P Salama, PJ Coffer, R Somasundaram, RJ O’Hara, S Hinz, S Hori, S K Ganapathi, S Ogino, S V Hodgson, SL Clarke, SM Phillips, T Blankenstein, T Sato, TJ Curiel, TJ Curiel, VC Petersen, W Zou, X Chen   +52 more
core   +2 more sources

Immune-mediated competition in rodent malaria is most likely caused by induced changes in innate immune clearance of merozoites [PDF]

, 2014
Malarial infections are often genetically diverse, leading to competitive interactions between parasites. A quantitative understanding of the competition between strains is essential to understand a wide range of issues, including the evolution of ...
A Gelman, AF Read, AJ O'Donnell, Andrew F. Read, AR Wargo, AR Wargo, AS Bell, BF Kochin, CJE Metcalf, D Cromer, DJC MacKay, DT Haydon, EM Pantelouris, G Snounou, GN Jakeman, H Haario, I Singer, IM Hastings, Jayanthi Santhanam, JC de Roode, JC de Roode, JC de Roode, JW Field, JW Field, KP Day, L Molineaux, L Raberg, Lars Råberg, LH Taylor, LH Taylor, LM van Putten, M Dyer, M Girolami, M Good, M Mackey, MC Bruce, Mercedes Pascual, MJ Mackinnon, MJ Mackinnon, MM Stevenson, MR Miller, N Friel, N Mideo, N Mideo, Nicholas Jon Savill, NJ Savill, PG McQueen, PH Abbrecht, R Antia, RO McAlister, TL Richie   +50 more
core   +4 more sources

Validation of Gene Profiles for Analysis of Regional Lymphatic Metastases in Head and Neck Squamous Cell Carcinoma

Frontiers in Molecular Biosciences, 2020
The progress of Head and Neck Squamous Cell Carcinoma (HNSCC) is dependent on both cancer stem cells (CSCs) and immune suppression. This study was designed to evaluate the distribution of CSCs and the characteristic immune suppression status in HNSCC ...
Zhenrong Hu, Zhenrong Hu, Ranran Yang, Ranran Yang, Li Li, Lu Mao, Lu Mao, Shuli Liu, Shuli Liu, Shuli Liu, Shichong Qiao, Guoxin Ren, Guoxin Ren, Guoxin Ren, Guoxin Ren, Jingzhou Hu, Jingzhou Hu, Jingzhou Hu, Jingzhou Hu   +18 more
doaj   +1 more source

TIMs, TAMs, and PS- antibody targeting: implications for cancer immunotherapy

Cell Communication and Signaling, 2020
Immunotherapy for cancer is making impressive strides at improving survival of a subset of cancer patients. To increase the breadth of patients that benefit from immunotherapy, new strategies that combat the immunosuppressive microenvironment of tumors ...
Adam S. Dayoub, Rolf A. Brekken
doaj   +1 more source

Immune suppression and immune activation in depression [PDF]

Brain, Behavior, and Immunity, 2011
Depression has been characterized as a disorder of both immune suppression and immune activation. Markers of impaired cellular immunity (decreased natural killer cell cytotoxicity) and inflammation (elevated IL-6, TNFα, and CRP) have been associated with depression.
Joshua, Blume, Steven D, Douglas, Dwight L, Evans   +2 more
openaire   +2 more sources