Results 51 to 60 of about 2,378,169 (247)

Potential uses of auditory nerve stimulation to modulate immune responses in the inner ear and auditory brainstem

Frontiers in Integrative Neuroscience, 2023
Bioelectronic medicine uses electrical stimulation of the nervous system to improve health outcomes throughout the body primarily by regulating immune responses. This concept, however, has yet to be applied systematically to the auditory system. There is
Benjamin J. Seicol, Benjamin J. Seicol, Zixu Guo, Zixu Guo, Katy Garrity, Ruili Xie, Ruili Xie   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Modulation of antigen-specific T-cells as immune therapy for chronic infectious diseases and cancer [PDF]

, 2014
Copyright: © 2014 Li, Symonds, Miao, Sanderson and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Miao, T, Ping eWang, Suling Li, Tizong Miao, Sanderson, I, Tizong eMiao, Ian eSanderson, Alistair L. J. Symonds, Ping Wang, Suling eLi, Ian Sanderson, Wang, P, Li, S, Symonds, ALJ   +13 more
core   +1 more source

Early growth response genes -2 and -3 are essential for optimal immune responses [PDF]

, 2013
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Early Growth Response Genes (EGR) is a family of four transcription factors containing a unique zinc finger domain.
Ghaffari, Emma Louise Marie
core   +4 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Landscape of stimulation-responsive chromatin across diverse human immune cells [PDF]

, 2019
A hallmark of the immune system is the interplay among specialized cell types transitioning between resting and stimulated states. The gene regulatory landscape of this dynamic system has not been fully characterized in human cells.
Vinh Nguyen, Criswell, Lindsey A, Greenleaf, William J, Jessica V. Ribado, Calderon, Diego, Beijing Wu, Franziska Blaeschke, William J. Greenleaf, Mezger, Anja, Wu, Beijing, Nguyen, Michelle LT, Fabian Müller, Gao, Ziyue, Burt, Trevor D, Michelle L. T. Nguyen, Anja Mezger, Diego Calderon, Knowles, David A, Kathiria, Arwa, Lindsey A. Criswell, Ribado, Jessica V, Parent, Audrey V, Trevor D. Burt, Trombetta, John, John Trombetta, David A. Knowles, Jonathan K. Pritchard, Blaeschke, Franziska, Lescano, Ninnia, Alexander Marson, Marson, Alexander, Mark S. Anderson, Anderson, Mark S, Ziyue Gao, Arwa Kathiria, Nguyen, Vinh, Ninnia Lescano, Pritchard, Jonathan K, Audrey V. Parent, Müller, Fabian, Mezger, A, Nguyen, V, Mueller, F, Kathiria, A, Nguyen, MLT, Calderon, D, Lescano, N, Wu, B, Trombetta, J, Ribado, JV   +49 more
core   +1 more source

Artificial Immune Systems - Models, algorithms and applications [PDF]

, 2010
Copyright © 2010 Academic Research Publishing Agency.This article has been made available through the Brunel Open Access Publishing Fund.Artificial Immune Systems (AIS) are computational paradigms that belong to the computational intelligence family and ...
Alsharhan, S, Al-Enezi, JR, Abbod, MF
core   +3 more sources

Helicobacter pylori infection and neopterin

Pteridines, 2001
In order to find out whether chronic immune stimulation is associated with Helicobacter pylori infection we studied 425 healthy individuals (aged 57.6 ± 9.22 years, s.d.) who were performing a health check up without having any specific health problems ...
Ledochowski Maximilian, Murr Christian, Lass-Flörl Cornelia, Fuchs Dietmar   +3 more
doaj   +1 more source