Results 121 to 130 of about 3,160,474 (348)

RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair

Nature Communications, 2016
Antigen receptor diversity relies on careful DNA cleavage and repair. Here the authors identify a functional interplay between RAG2 and XLF during V(D)J recombination, revealing an important role for the RAG complex in repairing induced DNA double-strand
Chloé Lescale, Vincent Abramowski, Marie Bedora-Faure, Valentine Murigneux, Gabriella Vera, David B. Roth, Patrick Revy, Jean-Pierre de Villartay, Ludovic Deriano   +8 more
doaj   +1 more source

The Impact of the Immune System on Tumor: Angiogenesis and Vascular Remodeling [PDF]

, 2014
Christian Stockmann, Dirk Schadendorf, Ralph Klose, Iris Helfrich   +3 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Sensing sperm via maternal immune system: a potential mechanism for controlling microenvironment for fertility in the cow [PDF]

, 2020
Mohamed Ali Marey, Mohamed Aboul Ezz, Ihshan Akthar, Mohamed Samy Yousef, Kazuhiko Imakawa, Masayuki Shimada, Akio Miyamoto   +6 more
openalex   +1 more source

European Code Against Cancer, 5th edition – hormone replacement therapy, other common medical therapies and cancer

Molecular Oncology, EarlyView.
The 5th edition of the European Code Against Cancer (ECAC5) contains 14 recommendations on cancer prevention. Here, we update the cancer prevention recommendations regarding the use of hormone replacement therapy (HRT), which is positioned as recommendation number 13 of the ECAC5.
Mangesh A. Thorat, Marc Arbyn, David Baldwin, Xavier Castells, Solveig Hofvind, Urska Ivanus, Carlo Senore, Esther Toes‐Zoutendijk, Carlijn van der Aalst, Carlos Canelo‐Aybar, Fiorella Karina Fernández‐Sáenz, Ariadna Feliu, Hajo Zeeb, Andre L. Carvalho, Erica D'Souza, David Ritchie, Carolina Espina, Iris Lansdorp‐Vogelaar, Andrea DeCensi   +18 more
wiley   +1 more source

Shaping Antitumor Immunity with Peptide Vaccines: Implications of Immune Modulation at the Vaccine Site

Vaccines
Cancer vaccines have emerged as a class of therapeutics designed to harness the immune system to stimulate durable anti-tumor responses with lower systemic toxicity than conventional therapies.
Amrita Sarkar, Emily Pauline Rabinovich, Craig Lee Slingluff   +2 more
doaj   +1 more source

The Potential Role of Schistosome-Associated Factors as Therapeutic Modulators of the Immune System [PDF]

, 2020
Junhui Li, Hong Liu, Jie Jiang, Xingguo She, Ying Niu, Yingzi Ming   +5 more
openalex   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

The Role of Sphingosine-1-Phosphate Transporter Spns2 in Immune System Function [PDF]

, 2012
Anastasia Nijnik, Simon Clare, Christine Hale, Jing Chen, Claire Raisen, Lynda Mottram, Mark Lucas, Jeanne Estabel, Edward J. Ryder, Hibret A. Adissu, Allan Bradley, Ramiro Ramírez‐Solis, David J. Adams, Jacqueline K. White, Niels C. Adams, Karen P. Steel, Bill Skarnes, Gordon Dougan, David Melvin, David Gannon, Mark Griffiths, Christian Kipp, Arthur Evans, S. Holroyd, Caroline Barnes, Emma L. Cambridge, Damian M. Carragher, Simon Clare, Kay Clarke, Hayley Protheroe, Jeanne Estabel, Anna-Karin Gerdin, Yvette Hooks, Natalia Igosheva, Ozama Ismail, Leanne Kane, Natasha A. Karp, David Lafont, Mark Lucas, Simon Maguire, Katherine McGill, Lynda Mottram, Lee Mulderrig, Christine Podrini, Hayley Protheroe, Laura Roberson, Grace Salsbury, Daniel Sanger, Mark Sanderson, Carl Shannon, David Sunter, Elizabeth Tuck, Valerie E. Vancollie, Debarati Bhattacharjee, Ross Cook, Diane Gleeson, Matt Hardy, Claire Haskins, Kalpesh Jhaveri, Stacey Price, Edward J. Ryder, Debarati Sethi, Sapna Vyas, Joanna Bottomley, Ellen Brown, James Bussell, Evelyn Grau, Richard Houghton, Harun Kundi, Alla Madich, Danielle Mayhew, Tom Metcalf, Stuart Newman, Laila Pearson, Caroline Sinclair, Hannah Wardle‐Jones, Mike Woods, Niels C. Adams, Ramiro Ramírez‐Solis, Jacqueline K. White, Karen P. Steel, Gordon Dougan, Robert E. W. Hancock   +82 more
openalex   +1 more source