Results 201 to 210 of about 1,883,048 (268)

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

How Histoplasma Evades the Human Immune System. [PDF]

Acta Med Acad
Kurniawan AJ, Mok JE, Putra A, Surja SS.
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Hitting the hidden: arming the immune system for the next zoonotic coronavirus spillover. [PDF]

J Clin Invest
Fricke C, Perlman S.
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Carotenoids and Their Interaction with the Immune System. [PDF]

Antioxidants (Basel)
Medina-García M, Baeza-Morales A, Martínez-Peinado P, Pascual-García S, Pujalte-Satorre C, Martínez-Espinosa RM, Sempere-Ortells JM.   +6 more
europepmc   +1 more source

Pathogens as commensals: microbial priming of the immune system and heterologous protection. [PDF]

Microbiology (Reading)
Belcher T, Stevens EJ.
europepmc   +1 more source

Nervous and immune system crosstalk shapes cancer progression and treatment response. [PDF]

Discov Oncol
TArdah M, AliBakr R, Malathi H, Arora V, PriyadarshiniNayak P, Urazbaeva D, Djumaniyazova M, Moxinur S, KarkonShayan F.   +8 more
europepmc   +1 more source

Spontaneous aging-associated inflammation and genome instability in the immune system of turquoise killifish. [PDF]

Nat Aging
Morabito G, Dönertas HM, Sperti L, Seidel J, Poursadegh Zonouzi A, Poeschla M, Valenzano DR.   +6 more
europepmc   +1 more source