Results 101 to 110 of about 3,749,228 (399)

Dissecting interferon-induced transcriptional programs in human peripheral blood cells [PDF]

, 2010
Interferons are key modulators of the immune system, and are central to the control of many diseases. The response of immune cells to stimuli in complex populations is the product of direct and indirect effects, and of homotypic and heterotypic cell ...
David A. Relman, Derya Unutmaz, Kathleen H. Rubins, Michael J. Griffiths, Michael Levin, Patrick O. Brown, Simon J. Waddell, Stephen J. Popper   +7 more
core   +4 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The Canadian collaborative project on genetic susceptibility to multiple sclerosis cohort population structure and disease etiology

Frontiers in Neurology
BackgroundPrevious genetic and epidemiological studies have examined subpopulations from the Canadian Collaborative Project on Genetic Susceptibility to Multiple Sclerosis (CCPGSMS) patient cohort, but an encompassing analysis of the study population has
Alison M. Pagalilauan, Alison M. Pagalilauan, Elif Everest, Elif Everest, Suzanna Rachimi, Suzanna Rachimi, Daniel S. Reich, Alex D. Waldman, Alex D. Waldman, Alex D. Waldman, A. Dessa Sadovnick, A. Dessa Sadovnick, Carles Vilarino-Guell, Michael J. Lenardo, Michael J. Lenardo   +14 more
doaj   +1 more source

Helminths in the hygiene hypothesis:Sooner or later? [PDF]

, 2014
There is increasing recognition that exposures to infectious agents evoke fundamental effects on the development and behaviour of the immune system. Moreover, where infections (especially parasitic infections) have declined, immune responses appear to be
Maizels, R. M., Mcsorley, H. J., Smyth, D. J.   +2 more
core   +4 more sources

miRNAs as Influencers of Cell-Cell Communication in Tumor Microenvironment [PDF]

, 2020
microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the posttranscriptional level, inducing the degradation of the target mRNA or translational repression.
Conti, Ilaria, Laface, Ilaria, Milani, Daniela, Neri, Luca M, Rimondi, Erika, Simioni, Carolina, Varano, Gabriele   +6 more
core   +1 more source

Aging and Neurodegenerative Disease: Is the Adaptive Immune System a Friend or Foe?

Frontiers in Aging Neuroscience, 2020
Neurodegenerative diseases of the central nervous system (CNS) are characterized by progressive neuronal death and neurological dysfunction, leading to increased disability and a loss of cognitive or motor functions.
K. Mayne, J. White, Christopher E. McMurran, F. Rivera, A. G. de la Fuente   +4 more
semanticscholar   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Revealing microbial recognition by specific antibodies [PDF]

, 2015
Background: Recognition of microorganisms by antibodies is a vital component of the human immune response. However, there is currently very limited understanding of immune recognition of 50 % of the human microbiome which is made up of as yet un ...
Collado, M. Carmen, Culshaw, Shauna, Džunková, Mária, D’Auria, Giuseppe, Mira, Alex, Simón-Soro, Áurea   +5 more
core   +1 more source

A molecular roadmap to the plant immune system

Journal of Biological Chemistry, 2020
Plant diseases caused by pathogens and pests are a constant threat to global food security. Direct crop losses and the measures used to control disease (e.g.
Adam R. Bentham, Juan Carlos de la Concepción, N. Mukhi, Rafał Zdrzałek, Markus Draeger, D. Gorenkin, R. Hughes, M. Banfield   +7 more
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source