Results 241 to 250 of about 3,492,274 (391)

Earthing effects on mitochondrial function: ATP production and ROS generation

FEBS Open Bio, EarlyView.
In contrast to sham and naive controls, grounded mitochondria not only exhibit significantly enhanced energy production but also demonstrate a remarkable reduction in membrane potential and oxidative stress. This suggests a profound improvement in mitochondrial health, presenting a promising avenue for therapeutic interventions.
Cecilia Giulivi, Richard Kotz
wiley   +1 more source

Gut microbiota-metabolome crosstalk in allergic diseases: mechanistic insights and translational opportunities. [PDF]

Front Allergy
Qin H, Sui J, Wang S, Lv X, Zhang Z, Lin X, Liu X, Zhang H.   +7 more
europepmc   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Autoimmune Diseases: Molecular Pathogenesis and Therapeutic Targets. [PDF]

MedComm (2020)
Song X, Liang H, Nan F, Chen W, Li J, He L, Cun Y, Li Z, Zhang W, Zhang D.   +9 more
europepmc   +1 more source

Systemic immune system alterations in early stages of Alzheimer's disease [PDF]

, 2013
Rongzhen Zhang, Robert G. Miller, Catherine Madison, Xia Jin, Ronald Honrada, Will Harris, Jonathan Katz, Dallas Forshew, Michael S. McGrath   +8 more
openalex   +1 more source

Matrix: a complex amalgam of structures and functions in tumor microenvironment

FEBS Open Bio, EarlyView.
The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis, Evgenia Tsoukala, Theodora D. Sarantopoulou, Maria‐Elpida Christopoulou   +3 more
wiley   +1 more source

Editorial: Next generation therapeutic modality to cure autoimmune diseases. [PDF]

Front Immunol
Chen G, Wang C, Wan Q, Dong F, Radstake T.   +4 more
europepmc   +1 more source

Role of the Innate Immune System in the Pathogenesis of Inflammatory Bowel Disease

, 2009
Pieter PE van Lierop, Janneke N. Samsom, Johanna C. Escher, Edward ES Nieuwenhuis   +3 more
openalex   +1 more source

Editorial: Peripheral immune system and neurodegenerative disease

Frontiers in Aging Neuroscience, 2022
Ke Zhang, Ke Zhang, Chao Wang, Jun-Liang Yuan, Yu Deng   +4 more
openaire   +3 more sources

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

FEBS Open Bio, EarlyView.
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda, Melissa Montrose, Akinori Takahashi, Risa Ishida, Sandrine Burriel, Nao Ohmine, Tohru Natsume, Shungo Adachi, Minsoo Kim, Tadashi Yamamoto   +9 more
wiley   +1 more source