Results 101 to 110 of about 1,940,460 (362)

Does Gestational Thrombocytopenia and Immune Thrombocytopenic Purpura Warrant Hospital Admission?

Pakistan Armed Forces Medical Journal
Objective: To determine the severity of thrombocytopenia in pregnancy and manage gestational thrombocytopenia patients in the outpatient department in order to reduce the economic burden on hospitals. Study Design: Cross-sectional study.
Ayesha Ellahi, Ayesha Nayyar, Maham Arshad, Wasiullah Khan, Afnan Naeem, Warda Furqan   +5 more
doaj   +1 more source

Fostamatinib and the risk of acute aortic dissection in immune thrombocytopenia

British Journal of Clinical Pharmacology, EarlyView.
Immune thrombocytopenia (ITP) is a rare autoimmune disorder characterized by platelet destruction. While most patients respond to first‐ or second‐line therapies, a small subset is multirefractory. Fostamatinib, an oral spleen tyrosine kinase (SYK) inhibitor, is a therapeutic option in these cases.
Paul Dalmas, Alexis Theron, Rita Badaoui, Stéphane Zaffran, Rayid Mchinda, Joelle Micallef, Nicolas Schleinitz, Mikael Ebbo   +7 more
wiley   +1 more source

Signal detection of immune thrombocytopenia associated with immune checkpoint inhibitors

Scientific Reports
Immune checkpoint inhibitors (ICIs) have become an important treatment modality for various malignancies. Due to excessive inflammatory and immune responses, immune-related adverse events (irAEs), such as rash, pruritis, pneumonitis, hepatitis ...
Diwei Mo, Xia Yang, Guifeng Xu, Xiaoyue Zhang, Keng Wang, Luwen Lei, Xingxi Pan   +6 more
doaj   +1 more source

The Centenary of Immune Thrombocytopenia—Part 2: Revising Diagnostic and Therapeutic Approach

Frontiers in Pediatrics, 2017
Primary immune thrombocytopenia (ITP) is the most common cause of thrombocytopenia in children and adolescents and can be considered as a paradigmatic model of autoimmune disease. This second part of our review describes the clinical presentation of ITP,
Rita Consolini, Giorgio Costagliola, Davide Spatafora   +2 more
doaj   +1 more source

Reference guide for management of adult immune thrombocytopenia in Japan: 2019 Revision

International journal of hematology, 2020
In 2012, ITP group of Blood Coagulation Abnormalities Research Team with funding from the Ministry of Health, Labour and Welfare Research Grant for Overcoming Intractable Diseases in Japan published a reference guide for management of adult immune ...
H. Kashiwagi, M. Kuwana, T. Hato, T. Takafuta, K. Fujimura, Y. Kurata, M. Murata, Y. Tomiyama   +7 more
semanticscholar   +1 more source

Neck‐vein thrombosis during spaceflight

British Journal of Clinical Pharmacology, EarlyView.
Spaceflight imposes unique environmental challenges, including weightlessness, increased radiation exposure and confinement, which can lead to unexpected health effects. One such example is neck‐vein thrombosis, a condition rarely seen on Earth without predisposing factors such as venous catheters or infections.
Ulrich Limper, Jens Jordan
wiley   +1 more source

Revisiting Clonal Evolution Through the Light of Retrotransposons

BioEssays, EarlyView.
We propose integrating retrotransposons into the clonal evolution model of cancer. Retrotransposons can modulate cancer cell fitness, potentially influencing clonal dynamics. They might also induce lineage violations via cell fusion or horizontal transfer.
Anaïs Lamoureux, Emilie Elvira‐Matelot, Françoise Porteu, Lucie Laplane   +3 more
wiley   +1 more source

Secondary immune thrombocytopenic purpura: An unusual complication of scrub typhus

Journal of Current Research in Scientific Medicine
Thrombocytopenia is a common manifestation of rickettsial disease. Immune thrombocytopenic purpura (ITP) is an acquired thrombocytopenia with antibodies detected against platelet surface antigens.
Jency Auxilia, Nivya Jeet Daniel, Nishanth Rajan   +2 more
doaj   +1 more source

Fostamatinib is an effective second‐line therapy in patients with immune thrombocytopenia

British Journal of Haematology, 2020
Fostamatinib demonstrated efficacy in phase 3 trials of adults with immune thrombocytopenia (ITP). Post hoc analysis compared patients who received fostamatinib as second‐line therapy (after steroids ± immunoglobulins) versus third‐or‐later‐line therapy (
R. Boccia, N. Cooper, W. Ghanima, M. Boxer, Q. Hill, M. Sholzberg, M. Tarantino, Leslie K. Todd, S. Tong, J. Bussel   +9 more
semanticscholar   +1 more source

Glycosaminoglycans as Polyelectrolytes: Charge, Interactions, and Applications

ChemBioChem, EarlyView.
Glycosaminoglycans (GAGs) are linear, anionic biopolymers with their functions tightly linked to their charge. This review approaches GAGs from a polyelectrolyte perspective, shedding light on how the distribution of sulfate groups and, thus, negative charges, governs their interactions with other biomolecules.
Gergo Peter Szekeres, Eunjin Moon, Johanna K. Elter, Bryce Roper, Jayachandran Narayanan Nair Kizhakkedathu, Matthias Ballauff, Rainer Haag, Kevin Pagel   +7 more
wiley   +1 more source