Results 21 to 30 of about 2,034,935 (392)

Delayed onset of severe immune thrombocytopenia associated with COVID-19 pneumonia

Respiratory Medicine Case Reports, 2021
A 72-year-old Japanese man was admitted to our hospital for treatment of severe COVID-19 pneumonia and was started on favipiravir, heparin calcium, and methylprednisolone pulse therapy. He recovered from respiratory failure about one month later. However,
Shintaro Sato, Moegi Kurachi, Hiroki Ohta, Tomohiko Nakamura, Tomohiro Oba, Rie Kawabe, Hideaki Yamakawa, Masako Amano, Hidekazu Matsushima   +8 more
doaj   +1 more source

Immune thrombocytopenia.

South Dakota medicine : the journal of the South Dakota State Medical Association, 2014
Immune thrombocytopenia (ITP) in children is a relatively uncommon and generally benign condition presenting as abrupt onset of bruising, petechiae and thrombocytopenia in an otherwise healthy child due to production of anti-platelet autoantibodies. Diagnosis is largely clinical and laboratory investigation should be kept to a minimum.
Mukhyaprana Prabhu, Sanketh Shah
  +9 more sources

Immune Thrombocytopenia: Recent Advances in Pathogenesis and Treatments

HemaSphere, 2021
Immune thrombocytopenia (ITP) is a rare autoimmune disease due to both a peripheral destruction of platelets and an inappropriate bone marrow production.
S. Audia, M. Mahévas, Martin Nivet, Séthi Ouandji, M. Ciudad, B. Bonnotte   +5 more
semanticscholar   +1 more source

Safety and efficacy of classical complement pathway inhibition with sutimlimab in chronic immune thrombocytopenia

Blood Advances, 2022
Key Points • Classical complement pathway activation contributes to the pathophysiology and clinical heterogeneity of immune thrombocytopenia (ITP).• Sutimlimab rapidly and durably increased platelet count in patients with chronic ITP by selectively ...
C. Broome, A. Röth, D. Kuter, M. Scully, Roy E. Smith, Jennifer P. Wang, C. Reuter, W. Hobbs, A. Daak   +8 more
semanticscholar   +1 more source

Phase I dose-escalation study of the mTOR inhibitor sirolimus and the HDAC inhibitor vorinostat in patients with advanced malignancy. [PDF]

, 2016
Preclinical models suggest that histone deacetylase (HDAC) and mammalian target of rapamycin (mTOR) inhibitors have synergistic anticancer activity. We designed a phase I study to determine the safety, maximum tolerated dose (MTD), recommended phase II ...
Falchook, Gerald S., Fanale, Michelle A., Fu, Siqing, Garrido-Laguna, Ignacio, Hong, David S., Janku, Filip, Kaseb, Ahmed O., Kurzrock, Razelle, Meric-Bernstam, Funda, Naing, Aung, Park, Haeseong, Patel, Shreyaskumar, Piha-Paul, Sarina A., Subbiah, Vivek, Tsimberidou, Apostolia M., Velez-Bravo, Vivianne M M., Wheler, Jennifer J., Zinner, Ralph G.   +17 more
core   +5 more sources

Transjugular intrahepatic portosystemic shunt, local thrombaspiration, and lysis for management of fulminant portomesenteric thrombosis and atraumatic splenic rupture due to vector-vaccine-induced thrombotic thrombocytopenia: a case report

Journal of Medical Case Reports, 2022
Introduction Recombinant adenoviral vector vaccines against severe acute respiratory syndrome coronavirus 2 have been observed to be associated with vaccine-induced immune thrombotic thrombocytopenia.
Sandra Emily Stoll, Patrick Werner, Wolfgang A. Wetsch, Fabian Dusse, Alexander C. Bunck, Matthias Kochanek, Felix Popp, Thomas Schmidt, Christiane Bruns, Bernd W. Böttiger   +9 more
doaj   +1 more source

Mycophenolate Mofetil for First-Line Treatment of Immune Thrombocytopenia.

New England Journal of Medicine, 2021
BACKGROUND Immune thrombocytopenia is a rare autoimmune disorder with associated bleeding risk and fatigue. Recommended first-line treatment for immune thrombocytopenia is high-dose glucocorticoids, but side effects, variable responses, and high relapse ...
C. Bradbury, J. Pell, Q. Hill, C. Bagot, N. Cooper, J. Ingram, Katie Breheny, R. Kandiyali, R. Rayment, G. Evans, K. Talks, Ian Thomas, R. Greenwood   +12 more
semanticscholar   +1 more source

Neonatal Immune Thrombocytopenia [PDF]

Medical Journal Armed Forces India, 2004
Neonatal immune thrombocytopenia, a consequence of transplacental transfer of antiplatelet antibodies can result in serious bleeding with disastrous consequences in the otherwise healthy newborn.Over 2 years at a service hospital, 5 mothers with chronic autoimmune thrombocytopenia and one with maternal alloimmunisation delivered, which comprised the ...
Uma, Raju, Punita, Arora
openaire   +2 more sources

Exacerbation of immune thrombocytopenia following COVID‐19 vaccination

British Journal of Haematology, 2021
There is concern that COVID‐19 vaccination may adversely affect immune thrombocytopenia (ITP) patients. Fifty‐two consecutive chronic ITP patients were prospectively followed after COVID‐19 vaccination.
D. Kuter
semanticscholar   +1 more source

Primary Immune Thrombocytopenia: Novel Insights into Pathophysiology and Disease Management

Journal of Clinical Medicine, 2021
Immune thrombocytopenia (ITP) is an autoimmune disorder defined by a significantly reduced number of platelets in blood circulation. Due to low levels of platelets, ITP is associated with frequent bruising and bleeding. Current evidence suggests that low
Anurag Singh, G. Uzun, T. Bakchoul
semanticscholar   +1 more source