Results 21 to 30 of about 1,952,392 (384)
Blood Advances, 2022 Key Points • Classical complement pathway activation contributes to the pathophysiology and clinical heterogeneity of immune thrombocytopenia (ITP).• Sutimlimab rapidly and durably increased platelet count in patients with chronic ITP by selectively ...
C. Broome +8 more
semanticscholar +1 more source
Thrombocytopenia in pregnancy: is this immune thrombocytopenia or…? [PDF]
Hematology, 2012 Abstract Thrombocytopenia is a common finding in pregnancy. Establishing the diagnosis of immune thrombocytopenia (ITP) in a pregnant patient is similar to doing so in a nonpregnant patient, except that the evaluation must specifically rule out other disorders of pregnancy associated with low platelet counts that present different risks ...
Terry Gernsheimer, Terry Gernsheimer
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Management of immune thrombocytopenia during COVID-19 pandemic
Russian journal of hematology and transfusiology, 2021 Introduction. The COVID-19 pandemic has challenged health professionals and patients suffering from haematological diseases with embarrassed diagnosis, treatment, surveillance, social distancing and other constraints.Aim — addressing therapy for immune ...
S. V. Semochkin, T. Mitina, T. Tolstykh
semanticscholar +1 more source
Phase I dose-escalation study of the mTOR inhibitor sirolimus and the HDAC inhibitor vorinostat in patients with advanced malignancy. [PDF]
, 2016 Preclinical models suggest that histone deacetylase (HDAC) and mammalian target of rapamycin (mTOR) inhibitors have synergistic anticancer activity. We designed a phase I study to determine the safety, maximum tolerated dose (MTD), recommended phase II ...
Falchook, Gerald S. +17 more
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Successful treatment of vaccine‐induced prothrombotic immune thrombocytopenia (VIPIT)
Journal of Thrombosis and Haemostasis, 2021 Cases of unusual thrombosis and thrombocytopenia after administration of the ChAdOx1 nCoV‐19 vaccine (AstraZeneca) have been reported. The term vaccine‐induced prothrombotic immune thrombocytopenia (VIPIT) was coined to reflect this new phenomenon.
J. Thaler +8 more
semanticscholar +1 more source
The Extensive Regulation of MicroRNA in Immune Thrombocytopenia
Clinical and applied thrombosis/hemostasis, 2022 MicroRNA (miRNA) is a small, single-stranded, non-coding RNA molecule that plays a variety of key roles in different biological processes through post-transcriptional regulation of gene expression.
Yuerong Zhao, S. Cui, Yan Wang, R. Xu
semanticscholar +1 more source
Journal of Medical Case Reports, 2022 Introduction Recombinant adenoviral vector vaccines against severe acute respiratory syndrome coronavirus 2 have been observed to be associated with vaccine-induced immune thrombotic thrombocytopenia.
Sandra Emily Stoll +9 more
doaj +1 more source
Immune Thrombocytopenia: Recent Advances in Pathogenesis and Treatments
HemaSphere, 2021 Immune thrombocytopenia (ITP) is a rare autoimmune disease due to both a peripheral destruction of platelets and an inappropriate bone marrow production.
S. Audia +5 more
semanticscholar +1 more source
Biomarkers for immune thrombocytopenia [PDF]
Biomarker Research, 2015 Immune thrombocytopenia is an autoimmune disease with abnormal biomarkers. Immune thrombocytopenia pathogenesis is a complicated process in which the patient's immune system is activated by platelet autoantigens resulting in immune mediated platelet destruction or suppression of platelet production.
Lingjia Yu +4 more
openaire +3 more sources
How I approach new onset thrombocytopenia
Platelets, 2020 Thrombocytopenia is a common reason for referral to hematologists in community and hospital practice. A broad differential diagnosis, combined with the potentially life-threatening nature of some presentations necessitates a rapid evaluation of the ...
Fiona Swain, Robert Bird
doaj +1 more source