Results 321 to 330 of about 1,940,460 (362)
Some of the next articles are maybe not open access.
Immune Thrombocytopenia Treatment
New England Journal of Medicine, 2021Idiopathic thrombocytopenia (ITP) has a long history. In 1025, Avicenna described in the Canon of Medicine a patient with characteristics of ITP, which became known as “idiopathic thrombocytopenic ...
Paula H.B. Bolton-Maggs, James N. George
openaire +2 more sources
Pathophysiology of immune thrombocytopenia
Current Opinion in Hematology, 2018Purpose of review Immune thrombocytopenia (ITP) is a common autoimmune bleeding disorder with as of yet, no established clinical prognostic or diagnostic biomarkers. Patients frequently experience a markedly decreased quality of life and may be at risk for severe/fatal haemorrhage.
Heyu Ni +3 more
openaire +3 more sources
Immune thrombocytopenia in children
Journal of Pediatric Hematology/Oncology, 1981Idiopathic thrombocytopenic purpura in the adult has a clearly established autoimmune etiology; IgG antiplatelet antibody is demonstrable on the patient's platelets and is frequently present in the serum. Platelet IgG is correlated inversely with the platelet count.
Margaret Karpatkin, Simon Karpatkin
openaire +3 more sources
Pathogenesis of immune thrombocytopenia
Autoimmunity Reviews, 2017Immune thrombocytopenia (ITP) is a rare autoimmune disease due to an abnormal T cell response, notably supported by splenic T follicular helper cells, that stimulates the proliferation and differentiation of autoreactive B cells. The antiplatelet autoantibodies they produce facilitate platelet phagocytosis by macrophages, essentially in the spleen ...
Matthieu Mahévas +4 more
openaire +2 more sources
2014
Immune thrombocytopenia (ITP) is an autoimmune, acquired disease of adults and children characterized by transient or persistent thrombocytopenia. Variability in natural history and response to therapy suggests that primary ITP is heterogeneous from a clinical and pathophysiological point of view.
James B. Bussel, Berengere Gruson
openaire +3 more sources
Immune thrombocytopenia (ITP) is an autoimmune, acquired disease of adults and children characterized by transient or persistent thrombocytopenia. Variability in natural history and response to therapy suggests that primary ITP is heterogeneous from a clinical and pathophysiological point of view.
James B. Bussel, Berengere Gruson
openaire +3 more sources
Hospital Practice, 1983
The common denominator of this group of disorders is bleeding due to antibody-mediated platelet destruction. The variations in clinical manifestation--ranging from mild to fatal--reflect the diverse origins of the troublesome antibodies: transplacental, exogenous, and autogenous.
openaire +2 more sources
The common denominator of this group of disorders is bleeding due to antibody-mediated platelet destruction. The variations in clinical manifestation--ranging from mild to fatal--reflect the diverse origins of the troublesome antibodies: transplacental, exogenous, and autogenous.
openaire +2 more sources
An update on the pathophysiology of immune thrombocytopenia
Current opinion in hematology, 2020Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder mediated by antiplatelet autoantibodies and antigen-specific T cells that either destroy platelets peripherally in the spleen or impair platelet production in the bone marrow.
J. Semple +3 more
semanticscholar +1 more source
Pathogenesis of immune thrombocytopenia
La Presse Médicale, 2014Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by antibody-mediated platelet destruction. The platelet, as an accessible target, has made ITP an attractive disorder in the study of autoimmunity. However, the pathogenesis of ITP has proven complex with diverse pre-existing challenges to the immune system in the form of infection ...
Adam Cuker +2 more
openaire +3 more sources
Other Immune Thrombocytopenias
Seminars in Hematology, 2007Immune thrombocytopenic purpura (ITP) can be classified as primary (known also as idiopathic thrombocytopenic purpura) or as secondary to an underlying condition such as a malignant or nonmalignant disorder. Commonly occurring conditions associated with secondary ITP include lymphoproliferative disorders (chronic lymphocytic leukemia [CLL], Hodgkin's ...
openaire +3 more sources