Results 201 to 210 of about 367,328 (307)

Multi-omics insights into immune tolerance at the maternal-fetal interface in recurrent pregnancy loss: mechanisms, integration challenges, and translational perspectives. [PDF]

Front Immunol
Shao M, Zhang Y, Tang H, Zhou Z, Zhai M, Zhou X, Bi X, Liao J, Zhang C, Jiang L.   +9 more
europepmc   +1 more source

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Hair follicle immune privilege in autoimmune and immune-mediated alopecias: paths toward reestablishing immune tolerance. [PDF]

Front Med (Lausanne)
Shafiei-Jahani P, Li X, Akbari A, Haniff E, Ziprick M, Carlisle R, Goh C, Holland V, Akbari O.   +8 more
europepmc   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Tolerance and Inflammation at the Gut Mucosa

Clinical and Developmental Immunology, 2012
Ana Maria C. Faria, Daniel Mucida, Donna-Marie McCafferty, Noriko M. Tsuji, Valerie Verhasselt   +4 more
doaj   +1 more source

Induction of immune tolerance in NMOSD and MOGAD. [PDF]

Ther Adv Neurol Disord
Correale J, Carnero Contentti E.
europepmc   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Loss of the autoimmune risk gene TREX1 reveals a convergence of mechanisms promoting immune tolerance loss and antitumor immunity. [PDF]

Sci Adv
Lim J, Williams K, Mittman S, Sanchez PP, Rodriguez R, Ogasawara A, Barnett G, Tleugabulova MC, Nabet BY, Hung J, Marroquin KA, Lau S, Lee SY, Tyler P, Carbone ET, Hough B, Corpuz J, Murota H, Dere E, Shiffman S, Schutt LK, Gill H, Lau J, De Simone M, Tam L, Roose-Girma M, Warming S, Oh SA, Rutz S, He MX, Müller S, West NR, Brewer TF, Desai P, Williams S, Ziai J, Qu Y, Heger K.   +37 more
europepmc   +1 more source

Editorial: Metabolism and Immune Tolerance

Frontiers in Immunology, 2018
Howie, Duncan, Mauro, Claudio
openaire   +3 more sources

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source