Results 191 to 200 of about 637,893 (254)

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source

Oral tolerogenic vaccine combined with gastrin restores immune tolerance and beta-cell function in NOD mice with Type 1 diabetes. [PDF]

Front Immunol
Cobb J, Rawson J, Gonzalez N, Kandeel F, Husseiny MI.   +4 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Oral antigen exposure under costimulation blockade induces Treg cells to establish immune tolerance. [PDF]

J Exp Med
Arai M, Kawakami R, Nakamura Y, Naito Y, Motooka D, Sugimoto A, Kimoto T, Ohkura N, Mikami N, Sakaguchi S.   +9 more
europepmc   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Neutrophil-associated plasma proteomics identifies HDAC1 as a baseline biomarker of immune tolerance during immunosuppressant withdrawal after pediatric liver transplantation: a single-center cohort study. [PDF]

Front Immunol
Wang R, Chen T, Liu Y, Zheng W, Dong C, Wang K, Sun C, Chen J, Xie E, Yang Y, Wang Z, Han C, Zhang Z, Zhao S, Wei X, Zou G, Fulati F, Song Z, Gao W.   +18 more
europepmc   +1 more source

Anti-PD-L1-IFN-α-adjuvanted HBsAg vaccine overcomes HBV immune tolerance through targeting both DCs and macrophages. [PDF]

JCI Insight
Meng CY, Liang Y, Xu L, Li H, Guo J, Xu H, Wang F, Fu YX, Peng H.   +8 more
europepmc   +1 more source

An Immunomodulating Peptide with Potential to Promote Anticancer Immunity Without Compromising Immune Tolerance. [PDF]

Biomedicines
Agrez M, Chandler C, Johnson AL, Sorensen M, Cho K, Parker S, Blyth B, Turner D, Rzepecka J, Knox G, Nika A, Hall AM, Gooding H, Gallagher L.   +13 more
europepmc   +1 more source

Correction: Tumor-derived exosomal tsRNA 3'tiRNA-AlaCGC in promoting fibroblast senescence and Galectin-9 secretion to induce immune tolerance in lung adenocarcinoma. [PDF]

Cell Death Discov
Zhao G, Zhang Y, Zhang H, Guo Y, Xu C, Ge D, Gu J.   +6 more
europepmc   +1 more source