Results 241 to 250 of about 288,299 (272)

Addendum: USP3 plays a critical role in the induction of innate immune tolerance. [PDF]

EMBO Rep
Duan T, Feng Y, Du Y, Xing C, Chu J, Ou J, Liu X, Zhu M, Qian C, Yin B, Wang HY, Cui J, Wang RF.   +12 more
europepmc   +1 more source

IFN-τ Maintains Immune Tolerance by Promoting M2 Macrophage Polarization via Modulation of Bta-miR-30b-5p in Early Uterine Pregnancy in Dairy Cows. [PDF]

Cells
Feng X, Yang C, Wang T, Zhang J, Zhou H, Ma B, Xu M, Deng G.   +7 more
europepmc   +1 more source

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Macroautophagy in Immunity and Tolerance

Traffic, 2009
Autophagy and proteasomal degradation constitute the two main catabolic pathways in cells. While the proteasome degrades primarily short‐lived soluble proteins, macroautophagy, the main constitutive autophagic pathway, delivers cell organelles and protein aggregates for lysosomal degradation.
Gannagé, M, Münz, C
openaire   +4 more sources

Autophagy and Immune Tolerance

2019
The immune system plays a critical role in defense against invading pathogens, and its function must be strictly controlled to maintain intracellular homeostasis. Once suffering microbial invasion or receiving danger signals, the immune system initiates the responses timely.
Jun Cui, Yaoxing Wu, Shouheng Jin
openaire   +2 more sources

Immune tolerance in allergy

Current Opinion in Immunology, 2009
Research on the mechanisms of immune regulation in allergy and asthma has shown substantial progress in recent years and has led to a variety of allergen-specific therapeutic and preventive approaches. Studies on the area of allergen-specific immunotherapy (allergen-SIT) have provided substantial knowledge on the mechanisms of allergic disease with ...
openaire   +3 more sources

Metabolic reinvigoration of immune tolerance [PDF]

Nature Reviews Rheumatology, 2021
New research shows that metabolic modulation can restore immune tolerance induction by anti-CD45RB antibodies in lupus-prone mice and reduce systemic lupus erythematosus-like pathology.
openaire   +2 more sources

The immune tolerance network and rheumatic disease: Immune tolerance comes to the clinic

Arthritis & Rheumatism, 2001
The development of effective, new, biologically based therapies for RA has created real excitement and justifiable optimism in recent years among rheumatologists and among patients with rheumatic diseases. Recent advances in our understanding of the mechanisms of immune activation and immune tolerance provide further cause for optimism.
Jeffrey A. Bluestone, Betty Diamond, David Wofsy   +2 more
openaire   +3 more sources

Immunity and tolerance to Aspergillus fumigatus.

Novartis Foundation symposium, 2006
The inherent resistance to diseases caused by Aspergillus fumigatus suggests the occurrence of regulatory mechanisms that provide the host with adequate defence without necessarily eliminating the fungus or causing unacceptable levels of host damage. Efficient responses to the fungus require different mechanisms of immunity.
MONTAGNOLI, Claudia, BOZZA, Silvia, Gaziano R, ZELANTE, TERESA, BONIFAZI, PIERLUIGI, MORETTI, SILVIA, BELLOCCHIO, Silvia, PITZURRA, Lucia, ROMANI, Luigina   +8 more
openaire   +5 more sources

Mechanisms of Immune Tolerance to Allergens

2012
In allergic diseases, immune responses are induced by normally well-tolerated allergens, which result in chronic inflammation characterized by antibody secretion and T cell activation. For almost 100 years, allergen-specific immunotherapy (allergen-SIT) has been the potentially curative and antigen-specific method for the treatment of allergic diseases.
Hiroyuki Fujita, Hiroyuki Fujita, Cezmi A. Akdis, Cezmi A. Akdis, Mübeccel Akdis, Norbert Meyer   +5 more
openaire   +4 more sources

Tolerance and Immunity in the Intestinal Immune System

Critical Reviews™ in Immunology, 2000
The intestinal immune system must guard the body against invasion by pathogens while avoiding a response to the many potential antigens present in food. In the absence of the inflammatory stimuli necessary to elicit an immune response, oral administration of soluble protein antigens induces antigen-specific systemic nonresponsiveness.
openaire   +2 more sources