Results 111 to 120 of about 792,578 (312)

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Flow‐based immunomagnetic enrichment of circulating tumor cells from diagnostic leukapheresis product

Molecular Oncology, EarlyView.
The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens, Anouk Mentink, Frank A. W. Coumans, Eshwari Dathathri, Khrystany T. Isebia, Jaco Kraan, Ronald de Wit, John W. M. Martens, Leon W. M. M. Terstappen   +8 more
wiley   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

The Effects of Citrullus Colocynthis (L.) Hydroalcoholic Extract on the Function of Lymphocyte Proliferation and Innate Immune System Responses after Challenge with the REV1 Vaccine in Wistar Rats [PDF]

Journal of Fasa University of Medical Sciences, 2016
Background & Objectives: The main objective of this study is to determine the possible effects of hydroalcoholic extract of Citrullus Colocynthis on the humoral and cellular immune responses in Wistar rats after challenge with REV-1 vaccine. Materials &
Meysam Abtahi Froushani, Saeed Nafisi, Hadi Esmaili Gourvarchin Galeh, Bahman Mansori Motlagh, Muhammad Seddigh Shahryari Nor   +4 more
doaj   +1 more source

Antigen-specific acquired immunity in human brucellosis: implications for diagnosis, prognosis, and vaccine development. [PDF]

, 2012
Brucella spp., are Gram negative bacteria that cause disease by growing within monocyte/macrophage lineage cells. Clinical manifestations of brucellosis are immune mediated, not due to bacterial virulence factors.
Alessandro eSette, Anthony P Cannella, Eduardo eGotuzzo, Joseph M Vinetz, Joseph M Vinetz, Li eLiang, Mayuko eSaito, Philip eFelgner, Renee M Tsolis   +8 more
core   +1 more source

Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies

Molecular Oncology, EarlyView.
Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren, Philippe Decruyenaere, Francisco Avila Cobos, Johanna Bult, Jill Deleu, Laudonia Lidia Dipalo, Hetty Hilde Helsmoortel, Eva Hulstaert, Annelien Morlion, Elena Ramos Varas, Kathleen Schoofs, Wim Trypsteen, Eveline Vanden Eynde, Hanne Van Droogenbroeck, Kimberly Verniers, Jo Vandesompele, Anneleen Decock   +16 more
wiley   +1 more source

Corrigendum to “Immunomodulatory Effects of Combination Therapy with Bushen Formula plus Entecavir for Chronic Hepatitis B Patients”

Journal of Immunology Research, 2022
Long-Shan Ji, Qiu-Tian Gao, Ruo-Wen Guo, Xin Zhang, Zhen-Hua Zhou, Zhuo Yu, XiaoJun Zhu, Ya-Ting Gao, Xue-Hua Sun, Yue-Qiu Gao, Man Li   +10 more
doaj   +1 more source

An Immune-related lncRNAs Model for Prognostic of SKCM Patients Base on Cox Regression and Coexpression Analysis [PDF]

arXiv, 2020
SKCM is the most dangerous one of skin cancer, its high degree of malignant, is the leading cause of skin cancer. And the level of radiation treatment and chemical treatment is minimal, so the mortality is high. Because of its complex molecular and cellular heterogeneity, the existing prediction model of skin cancer risk is not ideal. In this study, we
arxiv  

Assessing optimal target populations for influenza vaccination programmes: an evidence synthesis and modelling study. [PDF]

, 2013
BACKGROUND: Influenza vaccine policies that maximise health benefit through efficient use of limited resources are needed. Generally, influenza vaccination programmes have targeted individuals 65 y and over and those at risk, according to World Health ...
Baguelin, Marc, Camacho, Anton, Demiris, Nikolaos, Edmunds, W John, Flasche, Stefan, Miller, Elizabeth   +5 more
core   +3 more sources

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source