Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Evidence for long-term CD8<sup>+</sup> memory and functionally diverse CD4<sup>+</sup> helper responses following yellow fever vaccination: a systematic review. [PDF]
Front ImmunolCamara OL +3 more
europepmc +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Damage-Associated Molecular Patterns and Trained Immunity of Monocyte-Macrophage Populations in Osteoarthritis: Potential Molecular Links and Therapeutic Opportunities. [PDF]
CellsZhang J +7 more
europepmc +1 more source
INFLUENCE OF SARS-COV-2 MRNA BNT161B2 VACCINATION ON HUMORAL AND CELLULAR IMMUNITY IN PEDIATRIC STEM CELL TRANSPLANT PATIENTS Influence of SARS-CoV-2 mRNA BNT161b2 Vaccination on Humoral and Cellular Immunity in Pediatric Stem Cell Transplant Patients /
Thole, Linda Marie Laura
core
THE ROLE OF THE CELLULAR IMMUNITY IN THE POSTVACCINAL ANTIFOOT-AND-MOUTH DISEASE
, 1996 The object of investigation: the virus of the foot-and-mouth disease. The work is aimed at studying the cellular immunity with the introduction of the antifoot-and-mouth disease.
Davudov, Igor Vladimirovich
core
The multifaceted roles of lysosomes in cancer
Molecular Oncology, EarlyView.Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley +1 more source
Multiple Retransplantations After BK Polyomavirus-Associated Metastatic Collecting Duct Carcinoma: Evidence for Protective BK-specific T-Cell Immunity. [PDF]
TransplantationHammer N, Khanna N, Haidar F, Hirsch HH.
europepmc +1 more source
, 2003 Authors describe the essentials of the cellular immunity of Drosophila. They describe the Drosophila CD system, the main blood cell lineages and a blood cell differentiation model based on the expression of the CD antigens.
Hultmark, Dan, +10 more
core
The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Molecular Oncology, EarlyView.Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source