Results 81 to 90 of about 2,180,650 (301)

Malaria impairs T cell clustering and immune priming despite normal signal 1 from dendritic cells [PDF]

, 2007
Interactions between antigen-presenting dendritic cells (DCs) and T cells are essential for the induction of an immune response. However, during malaria infection, DC function is compromised and immune responses against parasite and heterologous antigens
Owain R Millington, Bernd H. Zinselmeyer, Zinselmeyer Bernd H, Brewer James M, Paul Garside, Rush, Catherine M., Rush, C.M., Owain R. Millington, Millington, O.R., Vivienne B Gibson, Catherine M. Rush, Bernd H Zinselmeyer, Rush, C., R. Stephen Phillips, Vivienne B. Gibson, Phillips, R.S., R Stephen Phillips, Catherine M Rush, Zinselmeyer, B.H., Millington, Owain R., Brewer, James M., Gibson Vivienne B, Millington Owain R, Brewer, J.M., Gibson, Vivienne B., Phillips R. Stephen, Garside Paul, Rush Catherine M, Phillips, R. Stephen, Zinselmeyer, Bernd H., Garside, P., James M. Brewer, Garside, Paul, James M Brewer   +33 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Corrigendum to “Immunomodulatory Effects of Combination Therapy with Bushen Formula plus Entecavir for Chronic Hepatitis B Patients”

Journal of Immunology Research, 2022
Long-Shan Ji, Qiu-Tian Gao, Ruo-Wen Guo, Xin Zhang, Zhen-Hua Zhou, Zhuo Yu, XiaoJun Zhu, Ya-Ting Gao, Xue-Hua Sun, Yue-Qiu Gao, Man Li   +10 more
doaj   +1 more source

Immunology of oral candidiasis

Journal of Pharmacy and Bioallied Sciences, 2014
A successful pathogen is one that is able to effectively survive and evade detection by the host immune defense. Oral candidiasis has adopted strategies, which evade host defense and eventually cause disease in at-risk patients.
Janardhanam Dineshshankar, Muniapillai Sivakumar, M Karthikeyan, P Udayakumar, K T Shanmugam, G Kesavan   +5 more
doaj   +1 more source

Proteomic Analysis of Kveim Reagent Identifies Targets of Cellular Immunity in Sarcoidosis - Table 1

, 2017
Proteomic Analysis of Kveim Reagent Identifies Targets of Cellular Immunity in Sarcoidosis - Table
Ajit Lalvani (182766), Nazneen Siddiqui (3692410), Athol U. Wells (420476), Rob Goldin (426160), Onn M. Kon (238235), Melissa Wickremasinghe (235318), Lee Potiphar (315764), Christian Eberhardt (315762), Mark E. Weeks (315770), Robert Parker (247304), Donald Mitchell (315772), Muhunthan Thillai (315761), John F. Timms (2273371)   +12 more
core   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Immunomodulatory effects of silymarin after subacute exposure to mice: A tiered approach immunotoxicity screening

Journal of Pharmacopuncture, 2018
Silymarin is a flavonoid complex extracted from the Silybum marianum plant with a wide range of pharmacological and biochemical effects. In the present study, the immunomodulatory effects of silymarin were investigated in BALB/c mice.
Gholamreza Karimi, Samed Hassanzadeh-Josan, Bahram Memar, Seyed-Alireza Esmaeili, Bamdad Riahi-Zanjani   +4 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Genomewide Analysis of Mode of Action of the S-Adenosylmethionine Analogue Sinefungin in Leishmania infantum

mSystems, 2019
To further our understanding of one-carbon metabolism in the protozoan parasite Leishmania, we conducted genomic screens to study how the parasite responded to sinefungin (SNF) selection.
Arijit Bhattacharya, Mansi Sharma, Charles Packianathan, Barry P. Rosen, Philippe Leprohon, Marc Ouellette   +5 more
doaj   +1 more source

Beyond Cellular Immunity: On the Biological Significance of Insect Hemocytes

, 2023
Insect immunity is assorted into humoral and cellular immune reactions. Humoral reactions involve the regulated production of anti-microbial peptides, which directly kill microbial invaders at the membrane and intracellular levels.
Yonggyun Kim, David Stanley, Eric Haas
core   +1 more source