Results 121 to 130 of about 164,492 (254)

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, EarlyView.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

Adolescents' Experiences of Hate Speech and Psychological Needs: A Reflexive Thematic Analysis

Journal of Adolescence, EarlyView.
ABSTRACT Introduction Adolescents are increasingly exposed to hate speech in both online and offline contexts, yet limited research has examined how such exposure is experienced and how it relates to adolescents' psychological needs and well‐being. Drawing on Self‐Determination Theory (SDT), this study explores how adolescents make sense of hate speech
Tomas Jungert, Camilla Forsberg, Robert Thornberg, Lisa Nordlund, Emelie Hansen, Elisa Lagerstedt, Coralie Levesque   +6 more
wiley   +1 more source

Beyond barrier function: keratinocytes as orchestrators of humoral immunity. [PDF]

Immun Inflamm
Guo C, Tsokos GC.
europepmc   +1 more source

Immunomodulation of the Prostate Tumor Microenvironment Following Inorganic Arsenic Exposure

Journal of Applied Toxicology, EarlyView.
ABSTRACT The tumor microenvironment (TME) influences prostate cancer (PCa) progression through stromal and immune interactions. Adipose‐derived mesenchymal stromal cells (ASCs) modulate immune tone, while inorganic arsenic (iAs), a widespread toxicant, is linked to immune suppression and carcinogenesis.
Joseph J. Shearer, Cosette Rivera‐Cruz, Alexandre M. B. Cavalca, Carlos Eduardo Fonseca‐Alves, Marxa L. Figueiredo   +4 more
wiley   +1 more source

Immunogenicity and safety of a third and subsequent COVID-19 vaccine doses in patients with plasma cell dyscrasias. [PDF]

Blood Adv
Bhella S, Agbayani G, Hueniken K, Vijenthira A, Wilkin AM, Sebag M, Wang P, Hicks LK, Hay AE, Hosseini-Moghaddam SM, Assouline S, Balitsky A, Fraser G, Mangel J, Owen C, Reiman A, Sehn L, Sutherland H, Arnold C, McCurdy A, Reece D, Leite T, McCarthy E, Cooper C, Crawley AM, Langlois MA, Buchan CA, Allan D, Aw A, Betschel S, Bolotin S, Brandwein J, Bredeson C, Brooks J, Cheung M, Chu M, Gupta V, Kekre N, Kumar D, Moltzan C, Prica A, Stakiw J, Wright A, Baetz T, Dudebout J.   +44 more
europepmc   +1 more source

Single‐Cell Profiling Identifies CLEC5A+ Macrophages as Key Drivers of Thoracic Aortic Aneurysm Via CCL5‐Mediated M1 Polarization

Journal of Clinical Laboratory Analysis, EarlyView.
Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li, Chunguang Guo, Mingyao Luo, Chang Shu   +3 more
wiley   +1 more source

Nasal humoral immunity: the first line of protection against respiratory pathogens. [PDF]

Immunohorizons
Hansen L, Guthmiller JJ.
europepmc   +1 more source

Analysis of the Recovery of Immune Status in the Patients With Paroxysmal Nocturnal Hemoglobinuria After Treatment With C5 Complement Inhibitor

Journal of Clinical Laboratory Analysis, EarlyView.
We retrospectively evaluated the impact of C5 complement inhibition on immune cell profiles and recovery in 27 PNH patients; both CD4+ and CD8+ T cells exhibited partial recovery, while B cell counts increased but remained below normal levels. In contrast, Treg cells were significantly reduced in PNH patients and showed no notable change post‐treatment.
Hui Liu, Mengting Che, Liyan Li, Honglei Wang, Chaomeng Wang, Junshu Wu, Yingying Chen, Zhaoyun Liu, Lijuan Li, Rong Fu   +9 more
wiley   +1 more source

Transient gingival inflammation is associated with epithelial dysfunction and systemic immune activation beyond clinical improvement

Journal of Periodontology, EarlyView.
Abstract Background The oral cavity significantly influences systemic health. Gingivitis, an early reversible stage of periodontal disease, may trigger systemic immune changes by facilitating bacterial translocation. This study examined the immune responses elicited by experimental gingivitis and their systemic immune impact, specifically in relation ...
Omnia Elebyary, Rachel Liu, Jinny Tsang, Chunxiang Sun, Bryan Coburn, Michael Glogauer   +5 more
wiley   +1 more source

Surveying immune and inflammatory alterations in periodontitis among individuals with Down syndrome: A preliminary cross‐sectional study

Journal of Periodontology, EarlyView.
Abstract Background Individuals with Down syndrome (DS) are particularly vulnerable to early‐onset and rapidly progressing periodontitis, yet the local immune‐inflammatory alterations that contribute to this susceptibility are not fully understood. This study aimed to characterize cytokine profiles in gingival crevicular fluid (GCF) from individuals ...
Leticia Helena Theodoro, João Victor Soares Rodrigues, Marta A. A. Nuernberg, Pedro Henrique Petrilli, Mabelle de Freitas Monteiro, Valdir Gouveia Garcia, Rafael Scaf de Molon, Renato Correa Viana Casarin   +7 more
wiley   +1 more source