Results 211 to 220 of about 561,668 (287)

Osteoarthritis: An Immuno‐Inflammatory Disease‐Mechanisms of Immune Cell Dysregulation and Potential Therapeutic Strategies

Med Research, EarlyView.
This review summarizes the immuno‐inflammatory mechanisms driving the pathogenesis of osteoarthritis (OA), extending beyond the traditional view of OA as a purely degenerative disease to incorporate immune cell infiltration, inflammatory factor release, and the formation of a chronic low‐grade inflammatory microenvironment.
Qingqiang Lei, Xiaoxian Lou, Xu Su, Shubao Liu, Yanli Tong, Jie Chen, Xuerui Chen, Wenjun Mao, Hui Yu, Liangbin Lin   +9 more
wiley   +1 more source

Protein Posttranslational Modifications in Immunity: Molecular Mechanisms and Therapeutic Targets. [PDF]

MedComm (2020)
Yao Y, Qian J, Liu Q, Ye W, Xing Y, Bai X, Deng R, Yang J, Lu C, Xiao C, Liu Y.   +10 more
europepmc   +1 more source

Proteomic Signatures of Ectopic Fat Distribution: Tissue‐Specific Drivers and Clinical Implications

Med Research, EarlyView.
Integration of plasma proteomics and multi‐organ MRI in 666 UK Biobank participants, combined with a knockoff‐based causal inference and machine learning framework, reveals organ‐specific drivers of ectopic fat: PLA2G1B (pancreas), ERBB2/IGFBP2 (liver), CA14 (muscle), and NCAM2/TNFRSF10B (pericardium). These drivers engage distinct pathways (e.g., PI3K‐
Bing Zhang, Fen Yang, Xingji Lian, Jie He, Shuijin Huang, Mingjuan Fan, Yin Liang, Jiaqiang Huang, LongYan Yin, Hong Wang   +9 more
wiley   +1 more source

SARS-CoV-2-specific immunity after XBB.1.5 vaccination is not significantly altered by subsequent influenza vaccination in dialysis patients. [PDF]

Sci Rep
Bronder S, Urschel R, Reinhardt F, Mihm J, Schlienger É, Schmidt T, Brückner S, Sester U, Sester M.   +8 more
europepmc   +1 more source

Cytokine Profiles in Myasthenia Gravis Subgroups and the Lack of Any Effect of Immunosuppression

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Myasthenia gravis (MG) is a clinically and immunologically heterogeneous autoimmune disease and there is little known about the differential effects of cytokines in disease subgroups. This study aimed to compare serum cytokine profiles across distinct MG subgroups, including early‐onset MG (EOMG), late‐onset MG (LOMG), muscle‐
Merve Cebi, Hacer Durmus, Arman Çakar, Mehmet Güven Günver, Yesim Parman, Feza Deymeer, Güher Saruhan‐Direskeneli   +6 more
wiley   +1 more source

Long-term immunity and protection against SARS-CoV-2 XBB.1.5 following homologous and heterologous mRNA and MVA vaccination. [PDF]

Front Immunol
Pérez P, Esteso G, García-García I, Flores S, Sánchez-Corzo C, Noriega MA, Casasnovas JM, Esteban M, García-Arriaza J.   +8 more
europepmc   +1 more source

The Mediating Role of Disengaged Coping in the Relationship Between Adverse Childhood Experiences and Substance Use Among Sexual Minority Adults

Research in Nursing &Health, EarlyView.
ABSTRACT Adverse childhood experiences (ACEs) are strongly linked to negative long‐term health outcomes. Sexual minority (SM) individuals face disproportionate exposure to ACEs and their consequences compared to heterosexual peers. However, the mechanisms connecting ACEs to these outcomes remain poorly understood.
Marvin A. Schilt‐Solberg, Julie J. A. M. J. Kurzer   +1 more
wiley   +1 more source

SARS-CoV-2 mRNA Vaccination Induces Reduced T-Cell Apoptosis in Patients with Solid Tumors. [PDF]

Int J Mol Sci
Belda-Marco A, Serrano-García L, Moret A, Fresneda-Portillo C, Domínguez-Márquez MV, Comes-Raga A, Jávega B, O'Connor JE, Andreu-Ballester JC, Llombart-Cussac A, Fernández-Murga ML.   +10 more
europepmc   +1 more source

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux, Nieves Velez de Mendizabal, Aksana Jones, Scott Balsitis, Stephan Schmidt, Justin S. Feigelman, Francine Johansson Azeredo   +6 more
wiley   +1 more source

Durability of COVID-19 vaccine-induced immunity in Saudi Arabia: evidence, gaps, and implications for Hajj and mass-gathering preparedness. [PDF]

Front Public Health
Azhar LE, Alsaieedi AA, AlEissa MM, Baroom HA, Alghoraibi AH, Alzahrani KS, Azhar EI.   +6 more
europepmc   +1 more source