Results 61 to 70 of about 2,437,393 (325)

Enhancing humoral immunity via sustained-release implantable microneedle patch vaccination

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Vaccine kinetics, the timing of antigen and/or adjuvant delivery to lymphoid organs, have recently been shown to substantially influence immune responses to subunit vaccines, but strategies to control vaccine kinetics in a clinically ...
Archana V. Boopathy, Anasuya Mandal, Daniel W. Kulp, Sergey Menis, Nitasha R. Bennett, H. Watkins, Wade Wang, Jacob T. Martin, Nikki Thai, Yanpu He, W. Schief, P. Hammond, D. Irvine   +12 more
semanticscholar   +1 more source

Effects of Biological Sex and Age on Cerebrospinal Fluid Markers—A Retrospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebrospinal fluid (CSF) analysis is a key diagnostic tool for neurological diseases. To date, only a few studies have investigated in larger cohorts the effect of age and biological sex on diagnostic markers extracted from CSF. Methods For this retrospective observational study, 4163 CSF findings (2012–2020) were evaluated.
Isabel‐Sophie Hafer, Simon Faissner, Ralf Gold, Aiden Haghikia   +3 more
wiley   +1 more source

Humoral Immune Response to AAV [PDF]

Frontiers in Immunology, 2013
Adeno-associated virus (AAV) is a member of the family Parvoviridae that has been widely used as a vector for gene therapy because of its safety profile, its ability to transduce both dividing and non-dividing cells, and its low immunogenicity. AAV has been detected in many different tissues of several animal species but has not been associated with ...
Calcedo, Roberto, Wilson, James M.
openaire   +3 more sources

Targeting the CD40-CD40L pathway in autoimmune diseases: Humoral immunity and beyond.

Advanced Drug Delivery Reviews, 2019
CD40 is a TNF receptor superfamily member expressed on both immune and non-immune cells. Interactions between B cell-expressed CD40 and its binding partner, CD40L, predominantly expressed on activated CD4+ T cells, play a critical role in promoting ...
J. Karnell, S. Rieder, R. Ettinger, R. Kolbeck   +3 more
semanticscholar   +1 more source

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

Advanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao, Abhisek Dwivedy, Payton L. Haak, Dhanush Gandavadi, Laurie A. Rund, Chi Chen, Vineetha Mareddy, Lifeng Zhou, Jinwei Duan, Ying Fang, Andrew J. Steelman, Xing Wang   +11 more
wiley   +1 more source

Assessing COVID IGRA and IgG antibodies in healthcare workers post vaccination

Journal of Infection in Developing Countries
Introduction: This study evaluated the durability of humoral and cell-mediated immunity (CMI) post Pfizer vaccination among healthcare workers (HCWs) at a tertiary care center in Lebanon.
Lina Ghandour, Wissam Yaacoub, George F Araj   +2 more
doaj   +1 more source

Five doses of the mRNA vaccination potentially suppress ancestral-strain stimulated SARS-CoV2-specific cellular immunity: a cohort study from the Fukushima vaccination community survey, Japan

Frontiers in Immunology, 2023
The bivalent mRNA vaccine is recommended to address coronavirus disease variants, with additional doses suggested for high-risk groups. However, the effectiveness, optimal frequency, and number of doses remain uncertain.
Yuta Tani, Morihito Takita, Morihito Takita, Masatoshi Wakui, Hiroaki Saito, Hiroaki Saito, Takamitsu Nishiuchi, Tianchen Zhao, Chika Yamamoto, Takeshi Kawamura, Takeshi Kawamura, Akira Sugiyama, Aya Nakayama, Yudai Kaneko, Yudai Kaneko, Tatsuhiko Kodama, Ryuzaburo Shinaha, Masaharu Tsubokura, Masaharu Tsubokura, Masaharu Tsubokura   +19 more
doaj   +1 more source

The Long Pentraxin PTX3 as a Humoral Innate Immunity Functional Player and Biomarker of Infections and Sepsis

Frontiers in Immunology, 2019
The first line of defense in innate immunity is provided by cellular and humoral mediators. Pentraxins are a superfamily of phylogenetically conserved humoral mediators of innate immunity.
R. Porte, S. Davoudian, Fatemeh Asgari, Raffaella Parente, A. Mantovani, C. Garlanda, B. Bottazzi   +6 more
semanticscholar   +1 more source

Precise Control of Drug Release in Machine Learning‐Designed Antibody‐Eluting Implants for Postoperative Scarring Inhibition in Glaucoma

Advanced Healthcare Materials, EarlyView.
We developed a micro‐sized, biocompatible implant for postoperative sustained delivery of anti‐fibrotic antibodies in glaucoma surgery. Machine learning‐guided optimization of polymer composition, implant geometry, and porosity enabled precise control of drug release.
Mengqi Qin, Wenbing Jiang, Kai Xin Thong, Zeynep Ulker, Brihitejas Patel, Cynthia Yu‐Wai‐Man   +5 more
wiley   +1 more source

Characteristics of cellular and humoral immunity parameters in patients with mechanical jaundice, caused by cholangiocarcinoma

Инфекция и иммунитет, 2022
In the modern world, obstructive jaundice caused by developing a malignant disease cholangiocarcinoma, poses a significant medical and social problem in economically developed and in developing countries.
Olga V. Smirnova, B. G. Gubanov, E. V. Kasparov, M. A. Darenskaya, L. I. Kolesnikova, S. N. Kolesnikov   +5 more
doaj   +1 more source