Results 201 to 210 of about 738,337 (299)

A novel cancer gene therapy achieving reciprocal regulation of PTEN and PARP1 expression. [PDF]

Mol Ther Oncol
Otsuka Y, Watanabe T, Kudo M.
europepmc   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

Excluded GM-specific IgG Subclass Genes in Health and Disease - Inborn Errors of Immunity. [PDF]

J Clin Immunol
Oxelius VA.
europepmc   +1 more source

Engineering Resatorvid‐Loaded Sub‐Microgels of Epigallocatechin‐3‐gallate/Hyaluronic Acid to Treat Acute Lung Injury

Advanced Healthcare Materials, EarlyView.
This study presents HAEP@Res sub‐microgels as a lung‐targeted delivery system integrating antioxidant activity with anti‐inflammatory therapy. The sub‐microgels demonstrate excellent biocompatibility, efficiently scavenge intracellular ROS, and downregulate pro‐inflammatory cytokines and genes in a Bleo‐induced ALI mouse model. These findings highlight
Bo Liu, Olawale Alimi Alimi, Benjamin Stearnes, Svetlana Romanova, Brady J. Sillman, Mena Asha Krishnan, Kristina Bailey, Benson J. Edagwa, Huanhuan Joyce Chen, Han‐jun Wang, Bin Duan   +10 more
wiley   +1 more source

Targeting innate immunity to modulate bone metabolism: a novel strategy for osteoporosis treatment. [PDF]

Front Aging
Kou W, Lu X, Zhang Z, Liu K, Liu Z, Jiang B, Wang H, Li J, Lu H, Guo C, Cao L, Zhang X.   +11 more
europepmc   +1 more source

Plant‐Produced Viral Nanoparticles Decorated with Nanobodies Against HER2 Improve Retention and Recruitment of Immune Cells in Solid Tumors

Advanced Healthcare Materials, EarlyView.
Potato virus X is a filamentous RNA plant virus that can be engineered into a molecular tool for cancer therapy. We produced genetically‐encoded virus‐derived nanoparticles decorated with nanobodies targeting cancer cell receptors, epidermal growth factor receptor (EGFR) and human epidermal growth factor 2 (HER2).
Enrique Lozano‐Sanchez, Miguel A. Moreno‐Gonzalez, Fernando Merwaiss, Nicole F. Steinmetz, José‐Antonio Daròs   +4 more
wiley   +1 more source

Parental polystyrene nanoplastics exposure increases susceptibility to pathogen infection in offspring via H3K36me3-UPR^ER-collagen pathway. [PDF]

Cell Commun Signal
Liu F, Zhang Y, Fu W, Cui Y, Xiao Y.
europepmc   +1 more source

Microengineered Gradient Hydrogels for Mechanobiology

Advanced Healthcare Materials, EarlyView.
Gradient hydrogels are used to mimic the mechanical heterogeneity in native tissues, offering powerful in vitro platforms to study cell‐material interactions in diverse pathophysiological contexts. Here, we present a comprehensive review of the design and experimental considerations for stiffness gradient hydrogels, discussing exemplary achievements ...
Shin Wei Chong, Deepu Ashok, Anna Waterhouse, Marcela M. M. Bilek, Daniele Vigolo   +4 more
wiley   +1 more source

Innate Immunity Trained in the Protective Response of Vaccine Candidates Against Intracellular Pathogens. [PDF]

Vaccines (Basel)
Oliveira JBS, Silva LA, Sousa MFS, Junior AMF, Almeida CG, Barducci RS, Milazzotto MP, Brandão HM, Santos RL, Paixão TA.   +9 more
europepmc   +1 more source

Innate Immunity and Acqired Immunity

Journal of Nippon Medical School, 2002
openaire   +3 more sources