Results 1 to 10 of about 137,978 (137)
Frontiers in Immunology, 2021 Mucosal nasal vaccine development, although ideal to protect from pathogens invading mucosally, is limited by the lack of specific adjuvant. We recently used P1, a conserved region of HIV-1 gp41-envelope glycoprotein, as efficient antigen in a ...
Lin Xu +8 more
doaj +1 more source
S100A8-mediated metabolic adaptation controls HIV-1 persistence in macrophages in vivo
Nature Communications, 2022 HIV-1 eradication is hindered by viral persistence in different cell reservoirs, including circulatory CD4+ T-cells and tissue-resident macrophages. Here, by analyzing male genital mucosa from cART-suppressed HIV1-infected individuals, Real et al.
Fernando Real +14 more
doaj +1 more source
Protocol to detect infectious SARS-CoV-2 at low levels using in situ hybridization techniques
STAR Protocols, 2023 Summary: Low and persistent levels of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA/protein/virus can be detected in clinical samples months after infection, possibly related to the emergence of SARS-CoV-2 variants or development of ...
Andréa Cottignies-Calamarte +4 more
doaj +1 more source
Frontiers in Immunology, 2020 Antibodies mediate a broad array of non-neutralizing Fc-mediated functions against HIV-1 including antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP).
Maxence Duchemin +11 more
doaj +1 more source
Frontiers in Immunology, 2021 BackgroundThe vasodilator neuropeptide calcitonin gene-related peptide (CGRP) plays both detrimental and protective roles in different pathologies. CGRP is also an essential component of the neuro-immune dialogue between nociceptors and mucosal immune ...
Jammy Mariotton +11 more
doaj +1 more source
Tuberculosis Risk Stratification of Psoriatic Patients Before Anti-TNF-α Treatment
Frontiers in Immunology, 2021 Psoriasis is a skin inflammatory condition for which significant progress has been made in its management by the use of targeted biological drugs. Detection of latent M.
Farida Benhadou +7 more
doaj +1 more source
Eliciting Mucosal Immunity [PDF]
New England Journal of Medicine, 2011 Eliciting mucosal immunity through vaccination has been problematic. Two recent studies suggest a strategy to achieve this goal.
Wayne I, Lencer, Ulrich H, von Andrian
openaire +2 more sources
Antibody Fc-chimerism and effector functions: When IgG takes advantage of IgA
Frontiers in Immunology, 2023 Recent advances in the development of therapeutic antibodies (Abs) have greatly improved the treatment of otherwise drug-resistant cancers and autoimmune diseases. Antibody activities are mediated by both their Fab and the Fc.
Andréa Cottignies-Calamarte +5 more
doaj +1 more source
Leptin and mucosal immunity [PDF]
Mucosal Immunology, 2012 Enhanced susceptibility to infection has long been recognized in children with congenital deficiency of leptin or its receptor. Studies in mice have demonstrated that leptin deficiency affects both the innate and acquired immune systems. Here, we review recent studies that demonstrate the impact on immunity of a common non-synonomous polymorphism of ...
Mackey-Lawrence, Nicole M. +1 more
openaire +2 more sources
Frontiers in Immunology, 2022 The new pandemic virus SARS-CoV-2 is characterized by uncontrolled hyper-inflammation in severe cases. As the IL-22/IL-22R1 axis was reported to be involved in inflammation during viral infections, we characterized the expression of IL-22 receptor1, IL ...
Nurhan Albayrak +12 more
doaj +1 more source