Results 21 to 30 of about 637,260 (296)

The Human Penis Is a Genuine Immunological Effector Site

Frontiers in Immunology, 2017
The human penis is a main portal of entry for numerous pathogens, and vaccines able to control resulting infections locally are highly desirable. However, in contrast to the gastrointestinal or vaginal mucosa, the penile immune system and mechanisms ...
Alexis Sennepin, Alexis Sennepin, Alexis Sennepin, Fernando Real, Fernando Real, Fernando Real, Marine Duvivier, Marine Duvivier, Marine Duvivier, Yonatan Ganor, Yonatan Ganor, Yonatan Ganor, Sonia Henry, Sonia Henry, Sonia Henry, Diane Damotte, Marc Revol, Sonia Cristofari, Morgane Bomsel, Morgane Bomsel, Morgane Bomsel   +20 more
doaj   +1 more source

Mucosal immunity and vaccines [PDF]

Nature Medicine, 2005
There is currently great interest in developing mucosal vaccines against a variety of microbial pathogens. Mucosally induced tolerance also seems to be a promising form of immunomodulation for treating certain autoimmune diseases and allergies. Here we review the properties of the mucosal immune system and discuss advances in the development of mucosal
Jan, Holmgren, Cecil, Czerkinsky
openaire   +2 more sources

Optimisation of ex vivo memory B cell expansion/differentiation for interrogation of rare peripheral memory B cell subset responses [version 2; referees: 2 approved]

Wellcome Open Research, 2018
Background: Human memory B cells play a vital role in the long-term protection of the host from pathogenic re-challenge. In recent years the importance of a number of different memory B cell subsets that can be formed in response to vaccination or ...
Luke Muir, Paul F. McKay, Velislava N. Petrova, Oleksiy V. Klymenko, Sven Kratochvil, Christopher L. Pinder, Paul Kellam, Robin J. Shattock   +7 more
doaj   +1 more source

Streptococcal Serine-Rich Repeat Proteins in Colonization and Disease

Frontiers in Microbiology, 2020
Glycosylation of proteins, previously thought to be absent in prokaryotes, is increasingly recognized as important for both bacterial colonization and pathogenesis.
Jia Mun Chan, Andrea Gori, Angela H. Nobbs, Robert S. Heyderman   +3 more
doaj   +1 more source

Experimental Models of Inflammatory Bowel DiseasesSummary

Cellular and Molecular Gastroenterology and Hepatology, 2015
The understanding of the intestinal inflammation occurring in the inflammatory bowel diseases (IBD) has been immeasurably advanced by the development of the now numerous murine models of intestinal inflammation.
Patricia Kiesler, Ivan J. Fuss, Warren Strober   +2 more
doaj   +1 more source

Early diagnosis of miliary tuberculosis in a hemodialysis patient by combining two interferon-γ-release assays: a case report

BMC Nephrology, 2020
Background Patients with end-stage renal disease undergoing chronic hemodialysis (HD) are at high risk to develop tuberculosis (TB) associated with a high mortality rate.
Florence Bonkain, Dieter De Clerck, Violette Dirix, Mahavir Singh, Camille Locht, Françoise Mascart, Véronique Corbière   +6 more
doaj   +1 more source

Mucosal Vaccines, Sterilizing Immunity, and the Future of SARS-CoV-2 Virulence [PDF]

, 2022
Sterilizing immunity after vaccination is desirable to prevent the spread of infection from vaccinees, which can be especially dangerous in hospital settings while managing frail patients. Sterilizing immunity requires neutralizing antibodies at the site
Casadevall A., Daniele Focosi, Fabrizio Maggi, Arturo Casadevall, Maggi F., Focosi D.   +5 more
core   +1 more source

Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue [PDF]

, 2011
The upper respiratory tract mucosa is the location for commensal Streptococcus (S.) pneumoniae colonization and therefore represents a major site of contact between host and bacteria.
Mitchell, T.J., Pido-Lopez Jeffrey, Pido-Lopez, J., Mitchell, TJ, Williams Neil A., Kwok, William W, Robert S. Heyderman, Neil A. Williams, Mitchell, Timothy J, Heyderman Robert S., Robert S Heyderman, Williams, NA, Pido, J, Neil A Williams, Mitchell Timothy J., Timothy J. Mitchell, Timothy J Mitchell, Heyderman, R.S., Pido-Lopez, Jeffrey, Kwok, W, Kwok William W., Williams, N.A., Heyderman, RS, William W Kwok, Jeffrey Pido-Lopez, Williams, Neil A, Kwok, W.W., William W. Kwok, Heyderman, Robert S   +28 more
core   +1 more source

HIV pathogenesis in the female genital tract during chronic HIV infection : the impact of inflammation, T cell memory differentiation status and homeostatic cytokines on mucosal T cell immunity [PDF]

, 2010
Includes bibliographical references (leaves 124-150).The female genital tract serves as the major portal of entry for human immunodeficiency virus (HIV).
Gumbi, Pamela
core   +1 more source

Monoclonal antibody against EV71 3Dpol inhibits the polymerase activity of RdRp and virus replication

BMC Immunology, 2019
Background Enterovirus A 71 (EV71) is a neurotropic virus that may lead to acute flaccid paralysis, encephalitis, cardiopulmonary failure or even death. No vaccine and defensive drug controlling EV71 is currently available, novel and efficient antiviral ...
Yaoming Li, Jie Yu, Xiuwen Qi, Huimin Yan   +3 more
doaj   +1 more source