Results 91 to 100 of about 1,491,491 (303)

Myeloid 12/15-LOX regulates B cell numbers and innate immune antibody levels in vivo [version 1; referees: 2 approved, 1 approved with reservations]

Wellcome Open Research, 2017
Background. The myeloid enzyme 12/15-lipoxygenase (LOX), which generates bioactive oxidized lipids, has been implicated in numerous inflammatory diseases, with several studies demonstrating an improvement in pathology in mice lacking the enzyme. However,
Sarah N. Lauder, Victoria J Tyrrell, Keith Allen-Redpath, Maceler Aldrovandi, David Gray, Peter Collins, Simon A Jones, Philip R Taylor, Valerie O'Donnell   +8 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Parasite infectivity and immunity to Plasmodium falciparum gametocytes in Gambian children.

, 2004
Immunity to the sexual stages of Plasmodium falciparum can be induced during natural infections. Characterization of this immunity may facilitate the design of a transmission-blocking vaccine (TBV).
Bousema, T., Greenwood, BM, Targett, GAT, Sauerwein, R, Teelen, K.A.E.M., Sauerwein, R.W., Drakeley, CJ, Targett, G.A.T., Bousema, JT, Eling, W.M.C., Greenwood, B.M., Eling, W, Drakeley, C., Teelen, K   +13 more
core   +1 more source

Insect immunity: the post-genomic era [PDF]

SummaryInsects have a complex and effective immune system, many components of which are conserved in mammals. But only in the last decade have the molecular mechanisms that regulate the insect immune response—and their relevance to general biology and ...
Lemaitre, Bruno, Jiggins, Frank, Bangham, Jenny   +2 more
core   +3 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The role of BRI1-associated kinase 1 (BAK1) in the regulation of plant innate immunity : functional and genetic characterization of BAK1 overexpression in Arabidopsis thaliana [PDF]

, 2014
The role of BRI1-ASSOCIATED KINASE 1 (BAK1) in the regulation of plant innate immunity: functional and genetic characterization of BAK1 overexpression in Arabidopsis thaliana SUMMARY BAK1 (BRI1-ASSOCIATED KINASE 1) is an intensively studied member ...
Kiss-Papp, Márta
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Development and characterization of immortalized mouse intestinal epithelial cell lines

Scientific Reports
Developing new tools for studying the intestinal epithelium aids in addressing unanswered questions in developmental biology, physiology, and disease pathology.
Julie Y. Zhou, Scott T. Espenschied, Qiuhe Lu, Paul E. Karell, Kelsey J. Lewis, Kevin P. Newhall, Yi Han, Meera Bambroo, Amalu Job, Thaddeus S. Stappenbeck   +9 more
doaj   +1 more source

Immunity in Tuberculosis [PDF]

Tuberculosis and Respiratory Diseases, 1981
In this review various aspects of tuberculo-immunity and of the pathogenesis and diagnosis of tuberculosis (TB) are examined in the light of current immunological knowledge. Successful resistance in TB is not easily predicted by the presence or absence of an immune response but it is a balance between the various types of immune responses of the host ...
openaire   +3 more sources