Results 91 to 100 of about 1,393,680 (310)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

High affinity is insufficient for strong B cell activation by HIV broadly neutralising antibodies

npj Vaccines
HIV broadly neutralizing antibodies (bnAbs) have been widely studied, and inducing a robust broadly neutralizing response remains a goal for many human vaccine studies. Much research focusses on creating higher affinity antigens to target bnAb precursors,
Chloe Rees-Spear, Olivia Payne, Emma Touizer, Alan Kennedy, Luke Muir, Peter Thomas, Alyssa Thomas DeCruz, Rachel A. McKendry, Leo Swadling, Marit J. van Gils, James E. Voss, Laura E. McCoy   +11 more
doaj   +1 more source

Interleukin-6 stimulates platelet 12-lipoxygenase to drive coagulation in inflammatory arthritis

Journal of Lipid Research
Rheumatoid arthritis (RA) is associated with significantly higher thrombotic risk, which is not mechanistically understood. In particular, the detailed mechanisms driving coagulation in arthritis have not been explored, despite the significant impact on ...
Daniela O. Costa, Stuart T.O. Hughes, Robert H. Jenkins, Ana Cardus Figueras, Majd B. Protty, Victoria J. Tyrrell, Ali A. Hajeyah, Gareth W. Jones, James J. Burston, Bethan Morgan, Federica Monaco, David Hill, Aisling S. Morrin, Carol Guy, Alice Bacon, Martin Giera, Rene E.M. Toes, P. Vince Jenkins, Peter W. Collins, Ernest Choy, Simon A. Jones, Valerie B. O’Donnell   +21 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Parasite infectivity and immunity to Plasmodium falciparum gametocytes in Gambian children. [PDF]

, 2004
Immunity to the sexual stages of Plasmodium falciparum can be induced during natural infections. Characterization of this immunity may facilitate the design of a transmission-blocking vaccine (TBV).
Bousema, T., Greenwood, BM, Targett, GAT, Sauerwein, R, Teelen, K.A.E.M., Sauerwein, R.W., Drakeley, CJ, Targett, G.A.T., Bousema, JT, Eling, W.M.C., Greenwood, B.M., Eling, W, Drakeley, C., Teelen, K   +13 more
core   +1 more source

Pre-Pandemic Cross-Reactive Immunity against SARS-CoV-2 among Siberian Populations

, 2023
In December 2019, a new coronavirus, SARS-CoV-2, was found to in Wuhan, China. Cases of infection were subsequently detected in other countries in a short period of time, resulting in the declaration of the COVID-19 pandemic by the World Health ...
Ekaterina A. Volosnikova, Iuliia A. Merkuleva, Artem A. Soroka, Anna V. Zaykovskaya, Svetlana A. Elchaninova, Oleg V. Pyankov, Olga N. Shaprova, Dmitry N. Shcherbakov, Nikita D. Ushkalenko, Sophia S. Borisevich, Evgeniia A. Kolosova, Tatiana N. Ilyicheva, Artem O. Nikitin, Daniil V. Shanshin   +13 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Carve-Outs Under Airline Antitrust Immunity [PDF]

This paper offers the first formal economic analysis of carve-outs under airline antitrust immunity. Carve-outs are designed to limit the potential anticompetitive effects of cooperation by alliance partners in hub-to-hub markets, where they provide ...
Jan K. Brueckner, Stef Proost
core   +2 more sources

Immunity and the emergence of individuality [PDF]

, 2013
Since (Buss 1987), it has become clear that individuality is not to be considered as a given, but rather as something which needs to be explained. How has individuality emerged through evolution, and how has it subsequently been maintained? In particular,
Pradeu, Thomas
core  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source