Results 81 to 90 of about 1,491,491 (303)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Effect of Dietary Supplementation on the Growth and Immunity of Fish and Shellfish—2nd Edition
With the development of the aquatic feed industry, new feedstuff and feed additives have been developed, but their roles in the growth and immunity of different aquaculture animals remain to be examined. In addition to essential nutrients, feedstuffs and
core +1 more source
TIGIT+Tfh show poor B-helper function and negatively correlate with SARS-CoV-2 antibody titre
Frontiers in ImmunologyCirculating follicular helper T cells (cTfh) can show phenotypic alterations in disease settings, including in the context of tissue-damaging autoimmune or anti-viral responses.
Natalie M. Edner +14 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Competition Law, Antitrust Immunity and Profits: A Dynamic Panel Analysis [PDF]
This paper tests whether the transition from the old Economic Competition Act, which was based on the so-called “abuse system”, to the new Competition Act, which was based on “prohibition system”, in the Netherlands had an impact on the price-cost ...
Brouwer, E., Ozbugday, F.C.
core
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
High affinity is insufficient for strong B cell activation by HIV broadly neutralising antibodies
npj VaccinesHIV broadly neutralizing antibodies (bnAbs) have been widely studied, and inducing a robust broadly neutralizing response remains a goal for many human vaccine studies. Much research focusses on creating higher affinity antigens to target bnAb precursors,
Chloe Rees-Spear +11 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Carve-Outs Under Airline Antitrust Immunity [PDF]
This paper offers the first formal economic analysis of carve-outs under airline antitrust immunity. Carve-outs are designed to limit the potential anticompetitive effects of cooperation by alliance partners in hub-to-hub markets, where they provide ...
Jan K. Brueckner, Stef Proost
core +2 more sources
Interleukin-6 stimulates platelet 12-lipoxygenase to drive coagulation in inflammatory arthritis
Journal of Lipid ResearchRheumatoid arthritis (RA) is associated with significantly higher thrombotic risk, which is not mechanistically understood. In particular, the detailed mechanisms driving coagulation in arthritis have not been explored, despite the significant impact on ...
Daniela O. Costa +21 more
doaj +1 more source