Results 61 to 70 of about 1,491,491 (303)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

IL-15 Overcomes Hepatocellular Carcinoma-Induced NK Cell Dysfunction

Frontiers in Immunology, 2018
NK cells have potent antitumor capacity. They are enriched in the human liver, with a large subset specialized for tissue-residence. The potential for liver-resident versus liver-infiltrating NK cells to populate, and exert antitumor functions in, human ...
Nicholas J. W. Easom, Kerstin A. Stegmann, Leo Swadling, Laura J. Pallett, Alice R. Burton, Dennis Odera, Nathalie Schmidt, Wei-Chen Huang, Wei-Chen Huang, Giuseppe Fusai, Brian Davidson, Mala K. Maini   +11 more
doaj   +1 more source

Immunity [PDF]

Public Health, 1894
n ...
openaire   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Voltage dip immunity of equipment in installations [PDF]

, 2007
This paper presents the status of the work in C4.110, a joint working group by CIGRE, CIRED and UIE. The scope of the working group is to gather technical knowledge on the immunity of equipment, installations and processes against voltage dips, and to ...
Stephens, M., Djokic, Sasa, Bollen, M., Romero Gordon, Jose, Stockman, K., McEachern, A.   +5 more
core  

RNAcare: integrating clinical data with transcriptomic evidence using rheumatoid arthritis as a case study

BMC Medical Genomics
Background Gene expression analysis is a crucial tool for uncovering the biological mechanisms that underlie differences between patient subgroups, offering insights that can inform clinical decisions.
Mingcan Tang, William Haese-Hill, Fraser Morton, Carl Goodyear, Duncan Porter, Stefan Siebert, Thomas D. Otto   +6 more
doaj   +1 more source

Contrasting roles for IKK-regulated inflammatory signalling pathways for development and maintenance of type 1 and adaptive γδ T cells

eLife
The inhibitor of kappa-B kinase (IKK) complex is a critical regulator of cell death and inflammatory signalling in multiple cell types. Phosphorylation of IκB proteins by IKK results in their degradation and consequent activation of NF-κB transcription ...
Farjana Islam, Cayman Williams, Thea Hogan, Louise V Webb, Ines Boal-Carvalho, Benedict Seddon   +5 more
doaj   +1 more source

In Silico and Structural Analyses Demonstrate That Intrinsic Protein Motions Guide T Cell Receptor Complementarity Determining Region Loop Flexibility

Frontiers in Immunology, 2018
T-cell immunity is controlled by T cell receptor (TCR) binding to peptide major histocompatibility complexes (pMHCs). The nature of the interaction between these two proteins has been the subject of many investigations because of its central role in ...
Christopher J. Holland, Christopher J. Holland, Bruce J. MacLachlan, Valentina Bianchi, Valentina Bianchi, Sophie J. Hesketh, Sophie J. Hesketh, Richard Morgan, Owen Vickery, Anna M. Bulek, Anna Fuller, Andrew Godkin, Andrew K. Sewell, Pierre J. Rizkallah, Stephen Wells, David K. Cole, David K. Cole   +16 more
doaj   +1 more source

Cutaneous lesions in psoriatic arthritis are enriched in chemokine transcriptomic pathways

Arthritis Research & Therapy, 2023
Objectives Skin from people with psoriasis has been extensively studied and is assumed to be identical to skin from those with psoriatic arthritis (PsA).
Hanna Johnsson, John Cole, Stefan Siebert, Iain B. McInnes, Gerard Graham   +4 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source