Results 61 to 70 of about 1,336,779 (318)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Methotrexate suppresses psoriatic skin inflammation by inhibiting muropeptide transporter SLC46A2 activity

, 2023
Cytosolic innate immune sensing is critical for protecting barrier tissues. NOD1 and NOD2 are cytosolic sensors of small peptidoglycan fragments (muropeptides) derived from the bacterial cell wall.
Nandy, Anubhab, Grimes, Catherine Leimkuhler, Kanneganti, Thirumala-Devi, Bharadwaj, Ravi, Wodzanowski, Kimberly A, Atukorale, Prabhani U, Orzalli, Megan H, Lusi, Christina F, Okuda, Kendi, Nagar, Abhinit, Anonick, Madison V, Silverman, Neal, Subbarao, Malireddi, Paik, Donggi, Kane, Griffin I, Monahan, Amanda, Brown, Ashley R, Goldman, William E, Mashayekh, Siavash   +18 more
core   +1 more source

Identification of Plasmodium falciparum translation initiation eIF2β subunit: direct interaction with Protein Phosphatase type 1

Frontiers in Microbiology, 2016
Protein phosphatase 1 (PP1c) is one of the main phosphatases whose function is shaped by many regulators to confer a specific location and a selective function for this enzyme. Here, we report that eukaryotic initiation factor 2 of P.
Géraldine eTellier, Astrid eLenne, Katia eCailliau Maggio, Alejandro eCabezas-Cruz, James eValdés, Alain eMartoriati, El Moukhtar eAliouat, Pierre eGosset, Baptiste eDelaire, Aline eFréville, Christine ePierrot, Jamal eKhalife   +11 more
doaj   +1 more source

STEAP4 expression in CNS resident cells promotes Th17 cell-induced autoimmune encephalomyelitis

Journal of Neuroinflammation, 2021
Background Multiple sclerosis (MS) is a debilitating neurological disease caused by autoimmune destruction of the myelin sheath. Experimental autoimmune encephalomyelitis (EAE) is a widely used animal model for the pathogenesis of MS.
Junjie Zhao, Yun Liao, William Miller-Little, Jianxing Xiao, Caini Liu, Xiaoxia Li, Xiao Li, Zizhen Kang   +7 more
doaj   +1 more source

Immunity [PDF]

Public Health, 1894
n ...
openaire   +3 more sources

Maternal Immunization [PDF]

Clinical Infectious Diseases, 2014
Pregnant women, neonates, and infants are at higher risk for severe infections due to vaccine‐preventable diseases. Very young infants rarely respond well to vaccination due to poor immunogenicity and interference from maternal antibody. Maternal immunization protects the mother and fetus from disease and protects the infant through transplacental ...
Helen Y, Chu, Janet A, Englund
openaire   +4 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Innate immunity in tuberculosis: myths and truth.

, 2008
Tuberculosis is the most important bacterial infection world wide. The causative agent, Mycobacterium tuberculosis survives and proliferates within macrophages.
Korbel, Daniel S, Bianca E. Schneider, Ulrich E. Schaible, Schaible, Ulrich E, Daniel S. Korbel, Schneider, Bianca E   +5 more
core   +1 more source

Innate immunity against HIV: a priority target for HIV prevention research. [PDF]

, 2010
This review summarizes recent advances and current gaps in understanding of innate immunity to human immunodeficiency virus (HIV) infection, and identifies key scientific priorities to enable application of this knowledge to the development of novel ...
PAXTON W, ROMARIS M, LINDBLAD E, DONCEL G, BORROW P, Persephone Borrow, Borrow, P, LEHNER T, DE MAGISTRIS MT, Shattock, Robin J., MEDAGLINI, DONATA, Vyakarnam, Annapurna, PATTERSON S, Annapurna Vyakarnam, POLI G, EUROPRISE WORKING GROUP BOGERS W, KIRCHHOFF F, KELLY C, TOWERS G, SILVESTRI G, DEBRE P, Robin J Shattock, Shattock, RJ, SHATTOCK RJ, Vyakarnam Annapurna, Borrow, Persephone, Borrow Persephone, GOODIER M, null null, SPECK R, EUROPRISE Working Group, GEIJTENBEEK T, Vyakarnam, A, Shattock Robin J, WAGNER H., VYAKARNAM A   +35 more
core   +1 more source