Results 41 to 50 of about 1,393,680 (310)

The long subclinical phase of Mycobacterium avium ssp. paratuberculosis infections explained without adaptive immunity [PDF]

, 2015
Mycobacterium avium ssp. paratuberculosis (MAP) is an infection of the ruminant intestine. In cows, a long subclinical phase with no or low intermittent shedding precedes the clinical phase with high shedding.
Klinkenberg, D., Sub Immunologie, Klinkenberg, Don, Koets, Ad, Ad Koets, Don Klinkenberg, Koets, A.P., FAH SIB, Infection & Immunity   +8 more
core   +2 more sources

Dendritic cell regulation of immunity to Leishmania donovani [PDF]

, 2010
Dendritic cells lie at the interface of innate and adaptive immunity, critically contributing to the generation of an antigen-specific immune response.
Owens, Benjamin M.J.
core   +3 more sources

Methotrexate suppresses psoriatic skin inflammation by inhibiting muropeptide transporter SLC46A2 activity [PDF]

, 2023
Cytosolic innate immune sensing is critical for protecting barrier tissues. NOD1 and NOD2 are cytosolic sensors of small peptidoglycan fragments (muropeptides) derived from the bacterial cell wall.
Nandy, Anubhab, Grimes, Catherine Leimkuhler, Kanneganti, Thirumala-Devi, Bharadwaj, Ravi, Wodzanowski, Kimberly A, Atukorale, Prabhani U, Orzalli, Megan H, Lusi, Christina F, Okuda, Kendi, Nagar, Abhinit, Anonick, Madison V, Silverman, Neal, Subbarao, Malireddi, Paik, Donggi, Kane, Griffin I, Monahan, Amanda, Brown, Ashley R, Goldman, William E, Mashayekh, Siavash   +18 more
core   +1 more source

Neuropsychological and Educational Outcomes in Shwachman–Diamond Syndrome—A Report From the North American Shwachman–Diamond Syndrome Registry

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Shwachman–Diamond syndrome (SDS) is a rare autosomal recessive ribosomopathy characterized by bone marrow failure and multisystem involvement, with emerging evidence of associated neurocognitive impairment. Methods We conducted a retrospective study of 240 individuals with biallelic Shwachman–Bodian–Diamond syndrome (SBDS) mutations
Jane Koo, Melissa Gerstle, Leah Cheng, Richard Cooper, Katherine Coyne, Claire Dusa, Naomi E. Joffe, Diana Schwarz, Sarah Steltz, Akiko Shimamura, Kasiani C. Myers, Thea Quinton   +11 more
wiley   +1 more source

Immune Dysregulation in Immune Thrombocytopenia [PDF]

Seminars in Hematology, 2013
Immune thrombocytopenia (ITP) is a bleeding disorder characterized by low platelet counts due to decreased platelet production as well as increased platelet destruction by autoimmune mechanisms. A shift toward Th1 and possibly Th17 cells together with impaired regulatory compartment, including T-regulatory (Tregs) and B-regulatory (Bregs) cells, have ...
Karina, Yazdanbakhsh, Hui, Zhong, Weili, Bao   +2 more
openaire   +2 more sources

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Hepatitis B: Model Systems and Therapeutic Approaches

Journal of Immunology Research
Hepatitis B virus (HBV) infection is a major global health issue and ranks among the top causes of liver cirrhosis and hepatocellular carcinoma. Although current antiviral medications, including nucleot(s)ide analogs and interferons, could inhibit the ...
Xiaoxiao Yu, Yating Gao, Xin Zhang, Longshan Ji, Miao Fang, Man Li, Yueqiu Gao   +6 more
doaj   +1 more source

The association between physical activity and mental health in medical postgraduates in China during COVID-19 pandemic

Frontiers in Psychiatry, 2022
BackgroundChinese medical postgraduates (CMPs) are a special subpopulation that has a great risk of mental health due to high workload, and heavy academic and clinical pressure during the COVID-19 pandemic.
Cai-Ling Yue, Xing Ge, Man Liu, Beibei Zhang, Stephane Koda, Chao Yan   +5 more
doaj   +1 more source

Sleep and Immunity [PDF]

Neuroscience and Behavioral Physiology, 2020
This review presents data on changes in measures of innate and adaptive immunity associated with the state of sleep. The effects of restricted and prolonged sleep duration on measures of morbidity, mortality, and susceptibility to infectious diseases and the effects of vaccination are discussed.
openaire   +3 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source