Nature Communications, 2022 Many cancer immune therapy approaches depend on an HLA-restricted neoantigen-specific T cell response. AUs show here that Zoledronic acid can expand, and induce tumour recognition by, a population of tissue resident memory gamma-delta T cells associated ...
Nekisa Zakeri +12 more
doaj +1 more source
Nuclear processes associated with plant immunity and pathogen susceptibility [PDF]
, 2015 Plants are sessile organisms that have evolved exquisite and sophisticated mechanisms to adapt to their biotic and abiotic environment. Plants deploy receptors and vast signalling networks to detect, transmit and respond to a given biotic threat by ...
Kulagina, Natalja +3 more
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Determination of the processes driving the acquisition of immunity to malaria using a mathematical transmission model. [PDF]
, 2007 Acquisition of partially protective immunity is a dominant feature of the epidemiology of malaria among exposed individuals. The processes that determine the acquisition of immunity to clinical disease and to asymptomatic carriage of malaria parasites ...
Filipe, João AN +9 more
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Age interactions in the development of naturally acquired immunity to Plasmodium falciparum and its clinical presentation. [PDF]
, 2007 BACKGROUND\ud \ud Naturally acquired malaria immunity has many determinants and, in the absence of immunological markers of protection, studies assessing malaria incidence through clinical endpoints remain an approach to defining immunity acquisition. We
Schellenberg, David +27 more
core +2 more sources
Innate cell profiles during the acute and convalescent phase of SARS-CoV-2 infection in children
Nature Communications, 2021 Childhood infection with SARS CoV2 is associated with a milder course of infection but the immunopathogenesis of this remains unclear. Here the authors explore immunological differences in the innate immune system during acute and convalescent SARS CoV2 ...
Melanie R. Neeland +11 more
doaj +1 more source
Mediators of Inflammation, 2023 Background. Neonatal sepsis is an extremely dangerous and fatal disease among neonates, and its timely diagnosis is critical to treatment. This research is aimed at evaluating the clinical significance of the lymphocyte-to-C-reactive protein ratio (LCR ...
Xiaojuan Li +8 more
doaj +1 more source
Th9 cells drive host immunity against gastrointestinal worm infection
, 2022 S.744-757Type 2 inflammatory cytokines, including interleukin-4 (IL-4), IL-5, IL-9, and IL-13, drive the characteristic features of immunity against parasitic worms and allergens. Whether IL-9 serves an essential role in the initiation of host-protective
Licona-Limon, I. +8 more
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Immunity, life history and conservation in the Galapagos sea lion [PDF]
, 2012 Infectious disease threatens health and biodiversity across the globe, and disease emergence may become more common as humans further encroach on habitats and modify environments. To assess the risks of disease emergence in natural populations accurately,
Brock, Patrick Michael
core +3 more sources
InnateDB: systems biology of innate immunity and beyond—recent updates and continuing curation [PDF]
, 2012 peer-reviewedInnateDB (http://www.innatedb.com) is an integrated analysis platform that has been specifically designed to facilitate systems-level analyses of mammalian innate immunity networks, pathways and genes.
Brinkman, Fiona S. L. +19 more
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Avidity of influenza-specific memory CD8+ T-cell populations decays over time compromising antiviral immunity [PDF]
, 2012 Decline of cell-mediated immunity is often attributed to decaying T-cell numbers and their distribution in peripheral organs. This study examined the hypothesis that qualitative as well as quantitative changes contribute to the declining efficacy of CD8+
James P. Hindley +35 more
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