Results 71 to 80 of about 1,393,680 (310)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Immunity [PDF]

Public Health, 1894
n ...
openaire   +3 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

STEAP4 expression in CNS resident cells promotes Th17 cell-induced autoimmune encephalomyelitis

Journal of Neuroinflammation, 2021
Background Multiple sclerosis (MS) is a debilitating neurological disease caused by autoimmune destruction of the myelin sheath. Experimental autoimmune encephalomyelitis (EAE) is a widely used animal model for the pathogenesis of MS.
Junjie Zhao, Yun Liao, William Miller-Little, Jianxing Xiao, Caini Liu, Xiaoxia Li, Xiao Li, Zizhen Kang   +7 more
doaj   +1 more source

ON IMMUNITY. [PDF]

The Lancet, 1891
n ...
openaire   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

The roles of Toll-like receptor 4 in the pathogenesis of pathogen-associated biliary fibrosis caused by Clonorchis sinensis

Scientific Reports, 2017
Pathogen-associated biliary fibrosis (PABF) is a type of liver fibrosis characterized by injuries of cholangiocytes and extra cellular matrix (ECM) deposition around bile ducts caused by various bacteria, fungi, virus and parasites.
Chao Yan, Bo Li, Fang Fan, Ying Du, Rui Ma, Xiao-Dan Cheng, Xiang-Yang Li, Bo Zhang, Qian Yu, Yu-Gang Wang, Ren-Xian Tang, Kui-Yang Zheng   +11 more
doaj   +1 more source

Identification of Plasmodium falciparum translation initiation eIF2β subunit: direct interaction with Protein Phosphatase type 1

Frontiers in Microbiology, 2016
Protein phosphatase 1 (PP1c) is one of the main phosphatases whose function is shaped by many regulators to confer a specific location and a selective function for this enzyme. Here, we report that eukaryotic initiation factor 2 of P.
Géraldine eTellier, Astrid eLenne, Katia eCailliau Maggio, Alejandro eCabezas-Cruz, James eValdés, Alain eMartoriati, El Moukhtar eAliouat, Pierre eGosset, Baptiste eDelaire, Aline eFréville, Christine ePierrot, Jamal eKhalife   +11 more
doaj   +1 more source

Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria [PDF]

, 2023
Inborn errors of human IFN-γ-dependent macrophagic immunity underlie mycobacterial diseases, whereas inborn errors of IFN-α/β-dependent intrinsic immunity underlie viral diseases. Both types of IFNs induce the transcription factor IRF1.
Ogishi, Masato, Soudée, Camille, Di Santo, James P, Oleaga-Quintas, Carmen, Rinchai, Darawan, Roelens, Marie, Rahman, Mahbuba, González, María Laura, Lorenzo, Lazaro, Mindt, Barbara C, Philippot, Quentin, Béziat, Vivien, Peel, Jessica N, Materna, Marie, Le Pen, Jérémie, Spaan, András N, Manry, Jérémy, Marr, Nico, Al Ali, Fatima, Bustamante, Jacinta, Zhang, Shen-Ying, Zhang, Qian, Ahmad Ata, Manar Mahmoud, Bourgey, Mathieu, Haake, Kathrin, Croft, Carys A, Seeleuthner, Yoann, Soulier, Jean, Rapaport, Franck, Pérez, Laura, Izquierdo, Helena M, Ma, Cindy S, Alyanakian, Marie-Alexandra, Vogt, Guillaume, Boisson-Dupuis, Stéphanie, Moncada-Vélez, Marcela, Paz, María Elvira Josefina, Lee, Danyel, Zhang, Peng, Lemon, Stanley M, Jeljeli, Mohamed, MacDonald, Margaret R, Doisne, Jean-Marc, Langlais, David, Manel, Nicolas, Daher, Wassim, Rice, Charles M, Rozenberg, Flore, Zhao, Shuxiang, Guérin, Antoine, Kendir-Demirkol, Yasemin, Liu, Zhiyong, Tahuil, Natalia, Bastard, Paul, Bohlen, Jonathan, Shirasaki, Takayoshi, Rosain, Jérémie, Migaud, Mélanie, Kremer, Laurent, Tangye, Stuart G, Bailey, Rasheed, Romana, Serge, Han, Ji Eun, Fritz, Jörg H, Lévy, Romain, Chan, Yi-Hao, L'Honneur, Anne-Sophie, Le Voyer, Tom, Türel, Özden, Hong, Seon-Hui, Martínez-Barricarte, Rubén, Lachmann, Nico, Cheung, Andrew, Michev, Alexandre, Emile, Jean-François, Neehus, Anna-Lena, Molina, Henrik, Heissel, Søren, Pochon, Mathieu, Abel, Laurent, Casanova, Jean-Laurent, Yang, Rui, Gros, Philippe, Khan, Taushif   +83 more
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