Results 71 to 80 of about 2,087,401 (308)

RNAcare: integrating clinical data with transcriptomic evidence using rheumatoid arthritis as a case study

BMC Medical Genomics
Background Gene expression analysis is a crucial tool for uncovering the biological mechanisms that underlie differences between patient subgroups, offering insights that can inform clinical decisions.
Mingcan Tang, William Haese-Hill, Fraser Morton, Carl Goodyear, Duncan Porter, Stefan Siebert, Thomas D. Otto   +6 more
doaj   +1 more source

Contrasting roles for IKK-regulated inflammatory signalling pathways for development and maintenance of type 1 and adaptive γδ T cells

eLife
The inhibitor of kappa-B kinase (IKK) complex is a critical regulator of cell death and inflammatory signalling in multiple cell types. Phosphorylation of IκB proteins by IKK results in their degradation and consequent activation of NF-κB transcription ...
Farjana Islam, Cayman Williams, Thea Hogan, Louise V Webb, Ines Boal-Carvalho, Benedict Seddon   +5 more
doaj   +1 more source

Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function

Nature Communications, 2019
Increasing TCR cell surface expression can potentiate T cell responses to low-concentrations of antigen. Here the authors identify aminoacids in human TCR variable domains that impact its surface expression, and demonstrate how editing these residues can
Sharyn Thomas, Fiyaz Mohammed, Rogier M. Reijmers, Annemarie Woolston, Theresa Stauss, Alan Kennedy, David Stirling, Angelika Holler, Louisa Green, David Jones, Katherine K. Matthews, David A. Price, Benjamin M. Chain, Mirjam H. M. Heemskerk, Emma C. Morris, Benjamin E. Willcox, Hans J. Stauss   +16 more
doaj   +1 more source

Clinical characteristics and risk factors for poor prognosis among HIV patients with Talaromyces marneffei bloodstream infection

BMC Infectious Diseases, 2021
Background Talaromyces marneffei (TM) bloodstream infection is common in Acquired Immunodeficiency Syndrome (AIDS) patients with extreme immunodeficiency in Southeast Asia and South China, however, clinical case study on TM bloodstream infection is ...
Jianjun Sun, Weiwei Sun, Yang Tang, Renfang Zhang, Li Liu, Yinzhong Shen, Jiangrong Wang, Jun Chen, Tangkai Qi, Zhenyan Wang, Wei Song, Yixiao Lin, Shuibao Xu, Hongzhou Lu   +13 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The mannose receptor (CD206) identifies a population of colonic macrophages in health and inflammatory bowel disease

Scientific Reports, 2021
To understand the contribution of mononuclear phagocytes (MNP), which include monocyte-derived intestinal macrophages, to the pathogenesis of inflammatory bowel disease (IBD), it is necessary to identify functionally-different MNP populations.
Pamela B. Wright, Elizabeth McDonald, Alberto Bravo-Blas, Hannah M. Baer, Anna Heawood, Calum C. Bain, Allan M. Mowat, Slater L. Clay, Elaine V. Robertson, Fraser Morton, Jagtar Singh Nijjar, Umer Z. Ijaz, Simon W. F. Milling, Daniel R. Gaya   +13 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Accountability, Immunity, & Impunity: How the UN Avoids Justice in Haiti [PDF]

, 2014
Following the devastating 2010 earthquake, the world’s largest cholera epidemic broke out on the island of Haiti, taking the lives of an estimated 8,500 and continuing to afflict more than 685,000. Scientific analysis undeniably traced the cholera strain
Schwab, Megan F.
core   +1 more source

Immunization Update IV

Advances in Pediatrics, 2009
With all the new vaccines and strategies for prevention, the most important challenge that one continues to talk about globally and at home is the one presented by ongoing transmission of diseases for which excellent vaccines already exist. As pediatricians, this presents a constant reminder to keep the conversation about the importance of vaccine ...
Department of Pediatrics, University of Florida, Pediatric Infectious Diseases, Immunology West 8th Street, LRC 3rd Floor, L-13 Jacksonville, FL 32209, USA ( host institution ), Mirza, Ayesha, Rathore, Mobeen H.   +3 more
openaire   +9 more sources

Immune Logics ain't that Immune

Logic and Logical Philosophy, 2022
Da Ré and Szmuc argue that while there is a symmetry between ‘infectious’ and ‘immune’ logics, this symmetry fails w.r.t. extending an algebra with an immune or an infectious element. In this paper, I show that the symmetry also fails w.r.t. defining a new logical operation from a given set of primitive (Boolean) operations.
openaire   +2 more sources