Results 131 to 140 of about 1,564,380 (249)

Multivariate mining of an alpaca immune repertoire identifies potent cross-neutralizing SARS-CoV-2 nanobodies

, 2022
Leo Hanke, Daniel J. Sheward, Alec Pankow, Laura Perez Vidakovics, Vivien Karl, Chang-Il Kim, Egon Urgard, Natalie Smith, Juan Astorga‐Wells, Simon Ekström, Jonathan M. Coquet, Gerald M. McInerney, Ben Murrell   +12 more
openalex   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Low-Affinity Memory CD8+ T Cells Mediate Robust Heterologous Immunity [PDF]

, 2016
Scott M. Krummey, Ryan J. Martinez, Rakieb Andargachew, Danya Liu, Maylene E. Wagener, Jacob E. Kohlmeier, Brian D. Evavold, Christian P. Larsen, Mandy L. Ford   +8 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Atypical patterns of response to immune checkpoint inhibitors: interpreting pseudoprogression and hyperprogression in decision making for patients’ treatment [PDF]

, 2019
Concetta Elisa Onesti, Pierre Frères, Guy Jérusalem   +2 more
openalex   +1 more source

Characterization of immune-related genes and immune infiltration features for early diagnosis, prognosis and recognition of immunosuppression in sepsis

, 2022
Jianhai Lu, Rui Chen, Yangpeng Ou, Qianhua Jiang, Liping Wang, Genglong Liu, Yayun Liu, Ben Yang, Zhujiang Zhou, Liuer Zuo, Zhen Chen   +10 more
openalex   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Can Nuclear Imaging Detect Trained Immunity in Cardiovascular Disease? [PDF]

Arterioscler Thromb Vasc Biol
Teunissen AJP, van Leent MMT.
europepmc   +1 more source

Editor’s Highlight: An Impaired Immune Tolerance Animal Model Distinguishes the Potential of Troglitazone/Pioglitazone and Tolcapone/Entacapone to Cause IDILI [PDF]

, 2017
Alastair Mak, Ryuji Kato, Kyle Weston, Anthony Hayes, Jack Uetrecht   +4 more
openalex   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source