Results 51 to 60 of about 1,053,446 (229)

Passive Immunization with Tau Oligomer Monoclonal Antibody Reverses Tauopathy Phenotypes without Affecting Hyperphosphorylated Neurofibrillary Tangles

Journal of Neuroscience, 2014
Recent findings suggest that tau oligomers, which form before neurofibrillary tangles (NFTs), are the true neurotoxic tau entities in neurodegenerative tauopathies, including Alzheimer's disease (AD).
D. Castillo-Carranza, U. Sengupta, M. Guerrero-Munoz, C. Lasagna-Reeves, J. Gerson, Gurpreet Singh, D. Estes, A. Barrett, K. Dineley, G. Jackson, R. Kayed   +10 more
semanticscholar   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

A systematic review of the burden of pertussis disease in infants and the effectiveness of maternal immunization against pertussis

Expert Review of Vaccines, 2020
Introduction Infants too young to be fully immunized are the most vulnerable to severe pertussis disease. To close this susceptibility gap, passive infant immunization through vaccination of pregnant women against pertussis was first introduced in 2011 ...
Walid Kandeil, C. van den Ende, E. Bunge, Victoria A Jenkins, M. Ceregido, A. Guignard   +5 more
semanticscholar   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Nanobody mediated inhibition of attachment of F18 fimbriae expressing Escherichia coli [PDF]

, 2014
Post-weaning diarrhea and edema disease caused by F18 fimbriated E. coli are important diseases in newly weaned piglets and lead to severe production losses in farming industry.
Coddens, Annelies, Cox, Eric, De Greve, Henri, De Kerpel, Maia, Moonens, Kristof, Pardon, Els, Remaut, Han   +6 more
core   +7 more sources

Molecular basis for passive immunotherapy of Alzheimer's disease [PDF]

, 2007
Amyloid aggregates of the amyloid-{beta} (A{beta}) peptide are implicated in the pathology of Alzheimer's disease. Anti-A{beta} monoclonal antibodies (mAbs) have been shown to reduce amyloid plaques in vitro and in animal studies.
A. S. Gardberg, Bard, Br  ckner, C. Dealwis, D. G. Myszka, Davis, Dobson, E. Helmbrecht, Emsley, Frenkel, Frenkel, Gevorkian, Giudicelli, Harper, Harris, Hyman, J. Ko, Kheterpal, Kheterpal, Kodali, L. T. Dice, Lavie, Murshudov, O'nuallain, P. H. Patterson, R. L. Rich, R. Wetzel, S. Ou, Schenk, Schilling, Seubert, Solomon, Solomon, Vaguine, Walsh, Weiner, Wetzel, Williams, Wu, Zhu   +39 more
core   +3 more sources

Reclaimed Homophobic Hate Speech Backfires: Desensitization and Mood Deterioration

European Journal of Social Psychology, EarlyView.
ABSTRACT Reclaimed hate speech is generally seen as a positive phenomenon by minority groups and, to some degree, by majority groups. However, previous research has not examined whether it might produce harmful effects similar to traditional hate speech.
Dominik Puchała, Michał Bilewicz, Aleksandra Świderska   +2 more
wiley   +1 more source

Targeting IL-6 by both passive or active immunization strategies prevents bleomycin-induced skin fibrosis

Arthritis Research & Therapy, 2014
IntroductionInterleukin-6 (IL-6) is a pleiotropic cytokine for which preliminary data have suggested that it might contribute to systemic sclerosis (SSc).
L. Desallais, J. Avouac, M. Fréchet, M. Elhai, R. Ratsimandresy, M. Montès, Hadley Mouhsine, H. Do, J. Zagury, Y. Allanore   +9 more
semanticscholar   +1 more source

Maternal RSV vaccination for infant protection: A systematic review and meta‐analysis of phase 3 trials with an integrated economic evaluation

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Background Respiratory syncytial virus (RSV) is a leading cause of hospitalization and mortality in early infancy. Maternal immunization offers a preventive strategy, but uncertainties regarding safety and economic value have limited its implementation.
Johnatan Torres‐Torres, Lourdes Rojas‐Zepeda, José Rafael Villafan‐Bernal, Raigam Martinez‐Portilla, Salvador Espino‐y‐Sosa, Pablo Cerda‐Flores, Elsa Romelia Moreno‐Verduzco, Irma Eloisa Monroy‐Muñoz, Ameyran Yolanda Gonzalez‐Guerrero, Juan Mario Solis‐Paredes, Javier Perez Duran   +10 more
wiley   +1 more source

Passive immunization to reduce Campylobacter jejuni colonization and transmission in broiler chickens

Veterinary Research, 2014
Campylobacter jejuni is the most common cause of bacterium-mediated diarrheal disease in humans worldwide. Poultry products are considered the most important source of C.
D. Hermans, K. van Steendam, E. Verbrugghe, M. Verlinden, A. Martel, Tomasz Seliwiorstow, M. Heyndrickx, F. Haesebrouck, L. De Zutter, D. Deforce, F. Pasmans   +10 more
semanticscholar   +1 more source