Results 51 to 60 of about 1,117,142 (241)

Immunization With Recombinant Haemonchus contortus Y75B8A.8 Partially Protects Local Crossbred Female Goats From Haemonchus contortus Infection

Frontiers in Veterinary Science, 2022
Haemonchus contortus Y75B8A.8 (Hc8) derived from H. contortus excretory–secretory (ES) products was identified as a functional inhibitor of goat interleukin 2 (IL-2). It may act as a vaccine candidate for the development of therapeutic strategies against
Xiaowei Tian, Xiaowei Tian, Mingmin Lu, Yongqian Bu, Yang Zhang, Kalibixiati Aimulajiang, Meng Liang, Charles Li, Ruofeng Yan, Lixin Xu, Xiaokai Song, Xiangrui Li, Xiangrui Li   +12 more
doaj   +1 more source

Engineering Tertiary Lymphoid Structures: Nanomedicine, Bioengineering, and Biomaterials for Precision Immunotherapy

Advanced NanoBiomed Research, EarlyView.
This review explains how biomaterials and nanoparticles can be used to induce or modulate tertiary lymphoid structures (TLSs), which are ectopic immune hubs that form in nonlymphoid tissues during chronic disease and cancer. By comparing different methods, the article highlights design principles for modeling TLSs or recapitulating specific TLS ...
Shaza Karaman, Mei ElGindi, Jeremy Teo
wiley   +1 more source

Passive Immunization with Phospho-Tau Antibodies Reduces Tau Pathology and Functional Deficits in Two Distinct Mouse Tauopathy Models

PLoS ONE, 2015
In Alzheimer’s disease (AD), an extensive accumulation of extracellular amyloid plaques and intraneuronal tau tangles, along with neuronal loss, is evident in distinct brain regions. Staging of tau pathology by postmortem analysis of AD subjects suggests
S. Sankaranarayanan, D. Barten, L. Vana, N. Devidze, Ling Yang, G. Cadelina, N. Hoque, L. Decarr, S. Keenan, Alan X. Lin, Yang Cao, B. Snyder, Bin Zhang, Magdalena Nitla, Gregg Hirschfeld, N. Barrezueta, C. Polson, P. Wes, V. Rangan, A. Cacace, C. Albright, J. Meredith, J. Trojanowski, V. Lee, K. Brunden, M. Ahlijanian   +25 more
semanticscholar   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Strategies used to improve immunization coverage of nirsevimab in an autonomous community in Spain

Human Vaccines & Immunotherapeutics
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections, particularly in infants under one year. In 2023, Spain became one of the first countries to implement nirsevimab, a long-acting monoclonal antibody, for RSV ...
Matilde Zornoza, Jesús Javier Yelo Cano, Jaime Jesús Pérez Martín   +2 more
doaj   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Duration of Passive Immunity [PDF]

Journal of Hygiene, 1922
1. The course of elimination of passive immunity in rabbits injected intravenously with diphtheria antitoxin obtained from a horse, consists of three phases:(a) an initial loss of 50 per cent, occurring within the first 24 hours;(6) a gradual constant percentage loss of approximately 25 per cent, from day to day, lasting 6–7 days;(c) a rapidly ...
A T, Glenny, B E, Hopkins
openaire   +3 more sources

Reclaimed Homophobic Hate Speech Backfires: Desensitization and Mood Deterioration

European Journal of Social Psychology, EarlyView.
ABSTRACT Reclaimed hate speech is generally seen as a positive phenomenon by minority groups and, to some degree, by majority groups. However, previous research has not examined whether it might produce harmful effects similar to traditional hate speech.
Dominik Puchała, Michał Bilewicz, Aleksandra Świderska   +2 more
wiley   +1 more source

Passive Immunization with Tau Oligomer Monoclonal Antibody Reverses Tauopathy Phenotypes without Affecting Hyperphosphorylated Neurofibrillary Tangles

Journal of Neuroscience, 2014
Recent findings suggest that tau oligomers, which form before neurofibrillary tangles (NFTs), are the true neurotoxic tau entities in neurodegenerative tauopathies, including Alzheimer's disease (AD).
D. Castillo-Carranza, U. Sengupta, Marcos J. Guerrero-Muñoz, C. Lasagna-Reeves, J. Gerson, Gurpreet Singh, D. Estes, A. Barrett, K. Dineley, G. Jackson, R. Kayed   +10 more
semanticscholar   +1 more source

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, EarlyView.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source