Results 31 to 40 of about 44,321 (240)

Preclinical active and passive immunization against prion disease.

, 2016
Preclinical active and passive immunization against prion disease.
Regina R. Reimann (695279), Uli S. Herrmann (124972), Simon Hawke (2180646), Tiziana Sonati (124969), Simone Hornemann (269068), Adriano Aguzzi (49294), Michael Arand (2180644)   +6 more
core   +1 more source

Cell-based passive immunization for protection against SARS-CoV-2 infection

Stem Cell Research & Therapy, 2023
Background Immunologically impaired individuals respond poorly to vaccines, highlighting the need for additional strategies to protect these vulnerable populations from COVID-19.
Evan Sawula, Shane Miersch, Eric D. Jong, Chengjin Li, Fang-Yu Chou, Jean Kit Tang, Reza Saberianfar, Jeffrey Harding, Sachdev S. Sidhu, Andras Nagy   +9 more
doaj   +1 more source

Vertical transmission of maternal COVID-19 antibodies after CoronaVac vaccine: A case report

Revista da Sociedade Brasileira de Medicina Tropical, 2021
The use of coronavirus disease 2019 RNA vaccines in pregnant women led to reports on the first cases of newborns with antibodies to sudden acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a phenomenon that was unknown when using immunizations with ...
Bruno Thizon Menegali, Fabiana Schuelter-Trevisol, Alexandre Naime Barbosa, Talita Menegali Izidoro, Otto Henrique May Feurschuette, Chaiana Esmeraldino Mendes Marcon, Daisson José Trevisol   +6 more
doaj   +1 more source

Senescent Cell Derived Artificial Vesicle‐Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross‐Presentation Efficacy

Advanced Science, EarlyView.
A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang, Yubo Lai, Jia Wang, Lingling Liu, Jieyuan An, Mi Qu, Yuan Liang, Bijun Tan, Guodong Yang, Xuekang Yang, Lijun Yuan   +10 more
wiley   +1 more source

Polyclonal hyper immunoglobulin: A proven treatment and prophylaxis platform for passive immunization to address existing and emerging diseases

Human Vaccines & Immunotherapeutics, 2022
Passive immunization with polyclonal hyper immunoglobulin (HIG) therapy represents a proven strategy by transferring immunoglobulins to patients to confer immediate protection against a range of pathogens including infectious agents and toxins.
Tharmala Tharmalingam, Xiaobing Han, Ashley Wozniak, Laura Saward   +3 more
doaj   +1 more source

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, EarlyView.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source

A brief history of antibody-based therapy

Neurobiology of Disease, 2019
Active and passive immunization have been used to treat human disease for hundreds of years and improvements in technology and knowledge is only increasing the number of therapeutic applications.
M. Alpaugh, F. Cicchetti
doaj   +1 more source

Active and passive immunizations with HtsA, a streptococcal heme transporter protein, protect mice from subcutaneous group A Streptococcus infection

Journal of Microbiology, Immunology and Infection, 2020
Background/Purpose: HtsA (Streptococcus heme transporter A) is the lipoprotein component of the streptococcal heme ABC transporter (HtsABC). The aim of this study is to investigate whether the HtsA protein has immunoprotective effect against group A ...
Yingli Song, XiaoLan Zhang, Minghui Cai, Chunmei Lv, Yuan Zhao, Deqin Wei, Hui Zhu   +6 more
doaj   +1 more source

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source

Animal models of idiopathic membranous nephropathy: Recent advances and future perspectives

Animal Models and Experimental Medicine, EarlyView.
This review focuses on the evolution of idiopathic membranous nephropathy (IMN) animal models from traditional approaches (Heymann nephritis, C‐BSA, APA) to antigen‐specific models (PLA2R, THSD7A), critically evaluating their advances and limitations in replicating human IMN pathology.
Qiuying Liu, Huixian Bian, Jianhua Liu, Lina Wu, Zhijie Zhang, Hongli Zhao, Xiaosong Qin   +6 more
wiley   +1 more source