Results 31 to 40 of about 709,989 (248)

Adaptation of Echinococcus Multilocularis to Oxidative Stress Depends on EmPDK‐Mediated Metabolic Reprogramming

Advanced Science, EarlyView.
Metabolic adaption presents a vital survival strategy for E. multilocularis. This study identifies EmPDK as a central metabolic regulator governing glucose metabolic reprogramming. Oxidative stress activates EmHIF1α to induce EmPDK expression. Mechanistic characterization reveals this ROS/EmHIF1α/EmPDK axis drives glycolytic reprogramming to sustain ...
Huijuan Wang, Zhijian Xu, Ye Tian, Yao Zhang, Zhe Cheng, Yanhai Wang   +5 more
wiley   +1 more source

Care and COVID 19: Lessons for liberals and neoliberals

Child &Family Social Work, EarlyView., 2023
Abstract Within the liberal political traditions, care is regarded as a private matter, a problem of ethics rather than justice. Social justice is framed as an issue of economics (re/distribution), culture (recognition) and/or politics (representation).
Kathleen Lynch
wiley   +1 more source

Cell-based passive immunization for protection against SARS-CoV-2 infection

Stem Cell Research & Therapy, 2023
Background Immunologically impaired individuals respond poorly to vaccines, highlighting the need for additional strategies to protect these vulnerable populations from COVID-19.
Evan Sawula, Shane Miersch, Eric D. Jong, Chengjin Li, Fang-Yu Chou, Jean Kit Tang, Reza Saberianfar, Jeffrey Harding, Sachdev S. Sidhu, Andras Nagy   +9 more
doaj   +1 more source

Vertical transmission of maternal COVID-19 antibodies after CoronaVac vaccine: A case report

Revista da Sociedade Brasileira de Medicina Tropical, 2021
The use of coronavirus disease 2019 RNA vaccines in pregnant women led to reports on the first cases of newborns with antibodies to sudden acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a phenomenon that was unknown when using immunizations with ...
Bruno Thizon Menegali, Fabiana Schuelter-Trevisol, Alexandre Naime Barbosa, Talita Menegali Izidoro, Otto Henrique May Feurschuette, Chaiana Esmeraldino Mendes Marcon, Daisson José Trevisol   +6 more
doaj   +1 more source

Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation

Advanced Science, EarlyView.
Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang, Wenhui Xie, Lei Yang, Zhengrong Wang, Yi Huang, Peng Huang, Yuan Liu, Jun Hu   +7 more
wiley   +1 more source

Polyclonal hyper immunoglobulin: A proven treatment and prophylaxis platform for passive immunization to address existing and emerging diseases

Human Vaccines & Immunotherapeutics, 2022
Passive immunization with polyclonal hyper immunoglobulin (HIG) therapy represents a proven strategy by transferring immunoglobulins to patients to confer immediate protection against a range of pathogens including infectious agents and toxins.
Tharmala Tharmalingam, Xiaobing Han, Ashley Wozniak, Laura Saward   +3 more
doaj   +1 more source

Triple‐Helix Biomolecules Construct Self‐Adaptive Multi‐Phase Interfaces for Dendrites Immunized Zinc Metal Anodes

Advanced Science, EarlyView.
A bio‐derived triple‐helix framework enables adaptive interphase engineering for aqueous Zn metal batteries. Directional Zn2+ migration channels and dynamic transformation into β‐sheet domains construct an optimized solid electrolyte interphase with flexible–rigid synergy, delivering dendrite‐free Zn deposition and exceptional long‐term battery cycling
Tianyi Wang, Jiahui Lu, Wei Gu, Jianfei Shi, Yuting Qin, Jian Yang, Di He, Zixia Lin, Jiabao Li, Bing Sun, Guoxiu Wang, Chengyin Wang   +11 more
wiley   +1 more source

A brief history of antibody-based therapy

Neurobiology of Disease, 2019
Active and passive immunization have been used to treat human disease for hundreds of years and improvements in technology and knowledge is only increasing the number of therapeutic applications.
M. Alpaugh, F. Cicchetti
doaj   +1 more source

Active and passive immunizations with HtsA, a streptococcal heme transporter protein, protect mice from subcutaneous group A Streptococcus infection

Journal of Microbiology, Immunology and Infection, 2020
Background/Purpose: HtsA (Streptococcus heme transporter A) is the lipoprotein component of the streptococcal heme ABC transporter (HtsABC). The aim of this study is to investigate whether the HtsA protein has immunoprotective effect against group A ...
Yingli Song, XiaoLan Zhang, Minghui Cai, Chunmei Lv, Yuan Zhao, Deqin Wei, Hui Zhu   +6 more
doaj   +1 more source

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source