Results 11 to 20 of about 709,989 (248)

Passive Immunization of Farmed Fish [PDF]

The Journal of Immunology, 2017
Abstract The fast growth and potential of global aquaculture has necessitated the adoption of sustainable and welfare-oriented therapeutics and prophylactic strategies. Knowledge gathered from studies about maternal passive immunity in fish and fish-to-fish passive immunization experiments supports the concept of using therapeutic Abs ...
Binoy, Rajan, Guro, Løkka, Erling Olaf, Koppang, Lars, Austbø   +3 more
openaire   +3 more sources

The biophysical principles underpinning muco-trapping functions of antibodies

Human Vaccines & Immunotherapeutics, 2022
In addition to the classical immunological functions such as neutralization, antibody-dependent cellular cytotoxicity, and complement activation, IgG antibodies possess a little-recognized and under-utilized effector function at mucosal surfaces ...
Alison Schaefer, Samuel K. Lai
doaj   +1 more source

Targeting Clostridium difficile Surface Components to Develop Immunotherapeutic Strategies Against Clostridium difficile Infection

Frontiers in Microbiology, 2018
New therapies are needed to prevent and treat Clostridium difficile infection and to limit the rise in antibiotic resistance. Besides toxins, several surface components have been characterized as colonization factors and have been shown as immunogenic ...
Séverine Péchiné, Jean F. Bruxelle, Claire Janoir, Anne Collignon   +3 more
doaj   +1 more source

The role of passive immunization in the age of SARS-CoV-2: an update

European Journal of Medical Research, 2020
The rapid spread of the corona virus pandemic is an existential problem for many people in numerous countries. So far, there is no effective vaccine protection or proven therapy available against the SARS-CoV-2 virus. In this review, we describe the role
Johannes C. Fischer, Kurt Zänker, Martijn van Griensven, Marion Schneider, Detlef Kindgen-Milles, Wolfram Trudo Knoefel, Artur Lichtenberg, Balint Tamaskovics, Freddy Joel Djiepmo-Njanang, Wilfried Budach, Stefanie Corradini, Ute Ganswindt, Dieter Häussinger, Torsten Feldt, Hubert Schelzig, Hans Bojar, Matthias Peiper, Edwin Bölke, Jan Haussmann, Christiane Matuschek   +19 more
doaj   +1 more source

Phase I Evaluation of Siltartoxatug, a First‐in‐Class Anti‐Tetanus Monoclonal Antibody: Safety, Pharmacokinetics and Pharmacodynamics in Healthy Australian and Chinese Populations [PDF]

Clin Pharmacol Ther
Siltartoxatug, a first‐in‐class monoclonal antibody targeting tetanus toxin for post‐exposure prophylaxis, was evaluated in two phase I trials in Australian and Chinese healthy adults. In these randomized, double‐blind, placebo‐controlled, dose‐escalation studies, participants received a single intramuscular injection of siltartoxatug (10–250 μg/kg) or
Liu X, Liu Z, Kuang X, Wang Y, Liu X, Ding J, Zhou X, Zhou X, Liang Q, Zhang M, Zhao H, Tan Q, Zheng W, Liao H, Lemech C, Wang W.   +15 more
europepmc   +2 more sources

Using Monoclonal Antibodies to Prevent Mucosal Transmission of Epidemic Infectious Diseases

Emerging Infectious Diseases, 1999
Passive immunization with antibodies has been shown to prevent a wide variety of diseases. Recent advances in monoclonal antibody technology are enabling the development of new methods for passive immunization of mucosal surfaces.
Larry Zeitlin, Richard A. Cone, Kevin J. Whaley   +2 more
doaj   +1 more source

Immunization technologies: Time to consider new preventative solutions for respiratory syncytial virus infections

Human Vaccines & Immunotherapeutics, 2023
New technologies for the prevention of infectious diseases are emerging to address unmet medical needs, in particular, the use of long-acting monoclonal antibodies (mAb) to prevent Respiratory Syncytial Virus (RSV) lower respiratory tract disease in ...
Catherine Weil-Olivier, David Salisbury, José Antonio Navarro-Alonso, Chryssoula Tzialla, Yan Zhang, Susanna Esposito, Fabio Midulla, Tobias Tenenbaum   +7 more
doaj   +1 more source

Immunization against multidrug-resistant Acinetobacter baumannii effectively protects mice in both pneumonia and sepsis models. [PDF]

PLoS ONE, 2014
OBJECTIVE: Acinetobacter baumannii is considered the prototypical example of a multi- or pan- drug-resistant bacterium. It has been increasingly implicated as a major cause of nosocomial and community-associated infections.
Weiwei Huang, Yufeng Yao, Qiong Long, Xu Yang, Wenjia Sun, Cunbao Liu, Xiaomei Jin, Yang Li, Xiaojie Chu, Bin Chen, Yanbing Ma   +10 more
doaj   +1 more source

Pharmacovigilance during mass immunization campaign with MenAfrivac τm in Cameroon [PDF]

, 2015
Background. Immunization is one of the most cost effective public health interventions and is estimated to have greatly reduced diseases, disabilities, deaths, and inequities worldwide.
Ateudjieu, Jerome
core   +1 more source

Region-Specific Effects of Immunotherapy With Antibodies Targeting α-synuclein in a Transgenic Model of Synucleinopathy

Frontiers in Neuroscience, 2018
Synucleinopathies represent a group of neurodegenerative disorders which are characterized by intracellular accumulation of aggregated α-synuclein. α-synuclein misfolding and oligomer formation is considered a major pathogenic trigger in these disorders.
Martin Kallab, Marcos Herrera-Vaquero, Malin Johannesson, Fredrik Eriksson, Jessica Sigvardson, Werner Poewe, Gregor K. Wenning, Eva Nordström, Nadia Stefanova   +8 more
doaj   +1 more source