Results 21 to 30 of about 41,253 (155)

Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease

Journal of Neuroinflammation, 2010
Background Passive immunization with antibodies directed to Aβ decreases brain Aβ/amyloid burden and preserves memory in transgenic mouse models of Alzheimer's disease (AD). This therapeutic strategy is under intense scrutiny in clinical studies, but its
Bosetti Francesca, Wetzel Ronald, Dealwis Chris, Prendergast Jay S, Rebeck G William, Mocchetti Italo, Niikura Takako, Aid Saba, Shimoji Mika, Sidahmed Elkhansa, Minami S Sakura, Matsuoka Yasuji, Hoe Hyang-Sook, Turner R Scott   +13 more
doaj   +1 more source

Cell-based passive immunization for protection against SARS-CoV-2 infection

Stem Cell Research & Therapy, 2023
Background Immunologically impaired individuals respond poorly to vaccines, highlighting the need for additional strategies to protect these vulnerable populations from COVID-19.
Evan Sawula, Shane Miersch, Eric D. Jong, Chengjin Li, Fang-Yu Chou, Jean Kit Tang, Reza Saberianfar, Jeffrey Harding, Sachdev S. Sidhu, Andras Nagy   +9 more
doaj   +1 more source

Vertical transmission of maternal COVID-19 antibodies after CoronaVac vaccine: A case report

Revista da Sociedade Brasileira de Medicina Tropical, 2021
The use of coronavirus disease 2019 RNA vaccines in pregnant women led to reports on the first cases of newborns with antibodies to sudden acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a phenomenon that was unknown when using immunizations with ...
Bruno Thizon Menegali, Fabiana Schuelter-Trevisol, Alexandre Naime Barbosa, Talita Menegali Izidoro, Otto Henrique May Feurschuette, Chaiana Esmeraldino Mendes Marcon, Daisson José Trevisol   +6 more
doaj   +1 more source

Active and passive immunizations with HtsA, a streptococcal heme transporter protein, protect mice from subcutaneous group A Streptococcus infection

Journal of Microbiology, Immunology and Infection, 2020
Background/Purpose: HtsA (Streptococcus heme transporter A) is the lipoprotein component of the streptococcal heme ABC transporter (HtsABC). The aim of this study is to investigate whether the HtsA protein has immunoprotective effect against group A ...
Yingli Song, XiaoLan Zhang, Minghui Cai, Chunmei Lv, Yuan Zhao, Deqin Wei, Hui Zhu   +6 more
doaj   +1 more source

Polyclonal hyper immunoglobulin: A proven treatment and prophylaxis platform for passive immunization to address existing and emerging diseases

Human Vaccines & Immunotherapeutics, 2022
Passive immunization with polyclonal hyper immunoglobulin (HIG) therapy represents a proven strategy by transferring immunoglobulins to patients to confer immediate protection against a range of pathogens including infectious agents and toxins.
Tharmala Tharmalingam, Xiaobing Han, Ashley Wozniak, Laura Saward   +3 more
doaj   +1 more source

A brief history of antibody-based therapy

Neurobiology of Disease, 2019
Active and passive immunization have been used to treat human disease for hundreds of years and improvements in technology and knowledge is only increasing the number of therapeutic applications.
M. Alpaugh, F. Cicchetti
doaj   +1 more source

Strategies used to improve immunization coverage of nirsevimab in an autonomous community in Spain

Human Vaccines & Immunotherapeutics
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections, particularly in infants under one year. In 2023, Spain became one of the first countries to implement nirsevimab, a long-acting monoclonal antibody, for RSV ...
Matilde Zornoza, Jesús Javier Yelo Cano, Jaime Jesús Pérez Martín   +2 more
doaj   +1 more source

T cell mediated cerebral hemorrhages and microhemorrhages during passive Aβ immunization in APPPS1 transgenic mice

Molecular Neurodegeneration, 2011
Background Immunization against amyloid-β (Aβ), the peptide that accumulates in the form of senile plaques and in the cerebrovasculature in Alzheimer's disease (AD), causes a dramatic immune response that prevents plaque formation and clears accumulated ...
de Calignon Alix, Spires-Jones Tara L, Mielke Matthew, Mora J Rodrigo, Meyer-Luehmann Melanie, von Andrian Ulrich H, Hyman Bradley T   +6 more
doaj   +1 more source

The burden of COVID-19 in a heterogeneous population of immunocompromised patients – realities of the postpandemic

Терапевтический архив, 2023
On July 3, 2023, an interdisciplinary Council of Experts The burden of COVID-19 in a heterogeneous population of immunocompromised patients post-pandemic realities was held in Moscow with leading experts in pulmonology, rheumatology, hematology ...
Sergey N. Avdeev, Vladimir P. Chulanov, Ekaterina I. Alexeeva, Olga A. Aleshina, Aleksey V. Bereznikov, Oleg N. Kotenko, Aleksander M. Lila, Zinaida Yu. Mutovina, Elena N. Parovichnikova, Daria S. Fomina, Nadiya F. Frolova, Alexey O. Shevchenko   +11 more
doaj   +1 more source

Emerging antibody-based products for infectious diseases: Planning for metric ton manufacturing

Human Vaccines & Immunotherapeutics, 2022
This review focuses on the emerging monoclonal antibody market for infectious diseases and the metric ton scale manufacturing requirements to meet global demand.
Kevin J Whaley, Larry Zeitlin
doaj   +1 more source