Results 41 to 50 of about 658,898 (341)

Breaking tolerance in transgenic mice expressing the human TSH receptor A-subunit: thyroiditis, epitope spreading and adjuvant as a 'double edged sword'. [PDF]

, 2012
Transgenic mice with the human thyrotropin-receptor (TSHR) A-subunit targeted to the thyroid are tolerant of the transgene. In transgenics that express low A-subunit levels (Lo-expressors), regulatory T cell (Treg) depletion using anti-CD25 before ...
Aliesky, Holly A, Chen, Chun-Rong, Chong, Gao, McLachlan, Sandra M, Rapoport, Basil   +4 more
core   +2 more sources

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Immunization Dynamics on a 2-layer Network Model

, 2003
We introduce a 2-layer network model for the study of the immunization dynamics in epidemics. Spreading of an epidemic is modeled as an excitatory process in a small-world network (body layer) while immunization by prevention for the disease as a dynamic
Albert, Albert, Amaral, Anderson, Barabási, Cohen, Cohen, Dezső, Ebel, Eguíluz, Faloutsos, Hang-Hyun Jo, Hie-Tae Moon, Jeong, Kuperman, Liljeros, Mikhailov, Murray, Newman, Pastor-Satorras, Pastor-Satorras, Seung Ki Baek, Watts, Watts, Zanette   +24 more
core   +1 more source

Fragmenting networks by targeting collective influencers at a mesoscopic level [PDF]

, 2016
A practical approach to protecting networks against epidemic processes such as spreading of infectious diseases, malware, and harmful viral information is to remove some influential nodes beforehand to fragment the network into small components.
Kobayashi, Teruyoshi, Masuda, Naoki
core   +3 more sources

Microphysiological Systems of Lymphatics and Immune Organs

Advanced Healthcare Materials, EarlyView.
This review surveys recent progress in engineering lymphatic microenvironments and immune organoids within microphysiological systems, emphasizing innovative strategies to recreate the biochemical and biophysical complexity of native lymphatic tissues.
Ishita Jain, Ankur Singh, Andrés J. García   +2 more
wiley   +1 more source

Characterization and control of small-world networks [PDF]

, 1999
Recently Watts and Strogatz have given an interesting model of small-world networks. Here we concretise the concept of a ``far away'' connection in a network by defining a {\it far edge}.
D. J. Watts, J. Gaure, J. J. Collins, J. J. Hopfield, R. E. Amritkar, S. A. Pandit, S. Milgram   +6 more
core   +2 more sources

Immune Dysregulation in Immune Thrombocytopenia [PDF]

Seminars in Hematology, 2013
Immune thrombocytopenia (ITP) is a bleeding disorder characterized by low platelet counts due to decreased platelet production as well as increased platelet destruction by autoimmune mechanisms. A shift toward Th1 and possibly Th17 cells together with impaired regulatory compartment, including T-regulatory (Tregs) and B-regulatory (Bregs) cells, have ...
Karina, Yazdanbakhsh, Hui, Zhong, Weili, Bao   +2 more
openaire   +2 more sources

Multivalent Protein Nanorings for Broad and Potent SARS‐CoV‐2 Neutralization

Advanced Healthcare Materials, EarlyView.
A protein‐only, modular multivalent nanoscaffold displaying 20 anchor points, decorated with two different binders (10 of each), targeting the SARS‐CoV‐2 receptor‐binding domain is presented. The construct self‐assembles into stable, biocompatible, homogeneous nanoparticles, exhibit synergistic binding with fM IC50 values. It also detects spike at 9 ng 
Molood Behbahanipour, Carla Goldin, Cecilia Arahi Prato, Ana Luz Paletta, Oriol Bárcenas, Susanna Navarro, Jordi Pujols, Daniel H. Murgida, María Virginia Tribulatti, Sebastián Esperante, Damian Alvarez‐Paggi, Salvador Ventura   +11 more
wiley   +1 more source

Changes in the epidemiology of hepatitis A in three socio-economic regions of China, 1990–2017

Infectious Diseases of Poverty, 2019
Background Hepatitis A (HepA) vaccination and economic transitions can change the epidemiology of HepA. China’s Gross Domestic Product (GDP) per capita was known to be inversely associated with the incidence of HepA, but a deeper understanding of the ...
Xiao-Jin Sun, Guo-Min Zhang, Rong-Jun Zhou, Hui Zheng, Ning Miao, Zun-Dong Yin, Fu-Zhen Wang   +6 more
doaj   +1 more source

Post-marketing safety surveillance study of a 9-valent human papillomavirus vaccine in individuals aged 16–26 years in Chongqing, China

Human Vaccines & Immunotherapeutics, 2023
The safety of human papillomavirus (HPV) vaccines, one of the major challenges to public vaccination, has been controversial. This study assessed the adverse reactions of 9-valent HPV (9vHPV) vaccines.
Yuan-yuan Zhang, Jia-Wei Xu, Yang Liu, Wei Qiu, Pei-Ning Bai, Yi Zeng, Qing Wang   +6 more
doaj   +1 more source