Results 241 to 250 of about 148,980 (309)

Simultaneous modification of Thermotoga maritima encapsulin subunits to produce multivalent nanoparticle vaccines for non‐typhoidal Salmonella enterica

The FEBS Journal, EarlyView.
This study investigates the modularity of encapsulin—a protein nanoparticle—by simultaneously inserting up to four distinct Salmonella epitopes within the encapsulin subunit. The encapsulin variants were transiently expressed in plants where they assembled into nanoparticles; however, their accumulation and stability varied depending on the ...
Carly A. Charron, Angelo Kaldis, Shabnam Shamriz, Moussa S. Diarra, Christopher P. Garnham, Rima Menassa   +5 more
wiley   +1 more source

On Racialized, Gendered, Precarious Work: Struggles of Community Health Workers During the National Health Insurance Pilot Program in the Tshwane District, South Africa

Gender, Work &Organization, EarlyView.
ABSTRACT The infrastructure of precarious work is racialized and gendered, affecting disenfranchised Black women who carry the burden of low paid caregiving within the healthcare system. In South Africa, Community Health Workers, predominantly Black women from marginalized communities, have been vital in providing primary healthcare services at home ...
Sivuyisiwe Wonci
wiley   +1 more source

Suppression of Indoleamine 2,3‐Dioxygenase Enhances Immune Responses to the Therapeutic Vaccine for Chronic Hepatitis B

Hepatology Research, EarlyView.
Indoleamine 2,3‐dioxygenase (IDO) activity modulates immune responses to the therapeutic HBV vaccine NASVAC. Genetic or pharmacological suppression of IDO enhanced vaccine efficacy in mice, and lower serum kynurenine levels predicted favorable responses in humans, suggesting IDO as both a therapeutic target and a biomarker.
Yohei Shirakami, Soranobu Ninomiya, Takayasu Ideta, Ayumu Kanbe, Toshihide Maeda, Daisuke Minowa, Daisuke Taguchi, Masaya Kubota, Hiroyasu Sakai, Kenji Imai, Yasuko Yamamoto, Hiroyasu Ito, Kuniaki Saito, Osamu Yoshida, Yoichi Hiasa, Masahito Shimizu   +15 more
wiley   +1 more source

Updated Burden and Long‐Term Projections of Chronic Hepatitis B and C in Japan: A Nationwide Markov Modeling Study

Hepatology Research, EarlyView.
ABSTRACT Aim Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections remain major causes of liver‐related morbidity and mortality worldwide. Although Japan has implemented nationwide screening and treatment programs for decades, updated nationwide estimates and long‐term projections are limited.
Junko Tanaka, Akemi Kurisu, Ko Ko, Aya Sugiyama, Tomoyuki Akita   +4 more
wiley   +1 more source

IL‐1β and IL‐6 synergistically drive murine TFH cell differentiation and maintenance in vitro

Immunology &Cell Biology, EarlyView.
We define a physiologically relevant in vitro system that demonstrates the combined function of T‐cell receptor signaling, IL‐6 and IL‐1β individually and jointly to promote TFH cell differentiation. These findings identify the essential requirements for generating functional TFH cells and clarify how cytokines shape their differentiation within the ...
Juliana Restrepo Munera, S Rameeza Allie
wiley   +1 more source

Recombinant zoster vaccine induces superior immunogenicity compared with live varicella vaccine in allogeneic haematopoietic stem cell transplantation recipients

British Journal of Haematology, EarlyView.
Takaaki Ono, Takashi Okada, Ryo Ikeda, Mitsuru Yamashita, Katsumi Koyauchi, Fumisato Takagi, Miwa Adachi, Tomonari Takemura, Kozue Mitsui, Yasuyuki Nagata   +9 more
wiley   +1 more source

Investigating Healthcare Educators' Interprofessional Socialisation Following an Interprofessional Simulation Facilitator Training Programme: A Mixed Methods Study

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim Interprofessional socialisation can contribute to collaborative patient care. Although there is research regarding interprofessional socialisation of healthcare students and frontline staff, there is limited literature regarding healthcare educators in practice settings.
Sara Dolan, Lorelli Nowell, Nancy Moules, Alyshah Kaba, Meredith Brockway   +4 more
wiley   +1 more source

Public Health Nurses' Time Allocation in Local Government Nursing Settings: A Self‐Reported Prospective Time Study

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To clarify how public health nurses allocate their time across various tasks and compare time‐use patterns between prefectural and municipal public health nurses in Japan, where distinct administrative mandates define their roles. Design A self‐reported, prospective time study.
Kyoko Yoshioka‐Maeda, Hiroshige Matsumoto, Chikako Honda, Kazuya Taira, Noriko Hosoya, Miki Sato, Riho Iwasaki‐Motegi, Yuka Sumikawa, Hitoshi Fujii, Takahiro Miura, Misa Shiomi   +10 more
wiley   +1 more source

Achieving Cancer Prevention Equity: A Policy Analysis of American Cancer Society HPV Vaccination Guidelines

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To examine the American Cancer Society's HPV vaccination guidelines through a nursing policy analysis framework, assessing justice and equity outcomes in cancer prevention policy implementation. Background Human papillomavirus vaccination remains critical for cancer prevention, yet persistent health disparities undermine equity goals ...
Grace K. Kyei, Evans K. Kyei, Rockson Ansong   +2 more
wiley   +1 more source

The Role of Nurses in General Practice: An Integrative Review

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To synthesise the literature around the roles of general practice nurses (GPNs) and the barriers and facilitators of their role. Design Integrative literature review using Whittemore and Knafls framework. Methods Papers were exported into Covidence for screening. Quality was appraised using the Mixed Method Appraisal Tool.
Asha Beattie, Sue Randall, Ruth Mursa, Elizabeth Halcomb   +3 more
wiley   +1 more source