Results 51 to 60 of about 68,916 (303)

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Health disparities in chronic liver disease

Hepatology, EarlyView., 2022
Abstract The syndemic of hazardous alcohol consumption, opioid use, and obesity has led to important changes in liver disease epidemiology that have exacerbated health disparities. Health disparities occur when plausibly avoidable health differences are experienced by socially disadvantaged populations.
Ani Kardashian, Marina Serper, Norah Terrault, Lauren D. Nephew   +3 more
wiley   +1 more source

Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro

Advanced Science, EarlyView.
The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel, Anna‐Sophie Schlemmer, Andrea W. Eiken, Zachary W. Wagoner, Dennis Vöhringer, Lena Christ, Alex Dulovic, Patrick Marsall, Madeleine Fandrich, Eduardo J. S. Brás, Julia Marzi, Friederike Bärhold, Julia Philipp, Sven Becker, Lisa E. Wagar, Peter Loskill   +15 more
wiley   +1 more source

Sustainable financing of immunization programs: A narrative review of the literature

Population Medicine
Countries have varied approaches to incorporating immunization into national health budgets, with limited evidence on best practices. The diversion of resources from routine immunization due to the pandemic highlights the need to increase sustainability ...
Vivian Yim, Mariel Cabrera, Michael Moore, Marta Lomazzi   +3 more
doaj   +1 more source

Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis

Advanced Science, EarlyView.
Amuc_1473, a previously uncharacterized protein enriched in Akkermansia muciniphila‐derived extracellular vesicles, is identified as a gut–bone messenger that promotes osteogenesis and inhibits osteoclastogenesis by engaging transcriptional and translational regulators in bone cells.
Shan‐Shan Rao, Hai‐Jin Zeng, Zun Wang, Chun‐Gu Hong, Yi‐Juan Tan, Yan‐Xin Duan, Jing‐Yao Luo, Ming‐Jie Luo, Yi‐Wei Liu, Xin Wang, Yi Luo, Teng‐Fei Wan, Yong Zhou, Zheng‐Guang Wang, Guo‐Wen Hu, Hao Yin, Xin‐Yue Hu, Zhen‐Xing Wang, Ze‐Hui He, Si‐Yi Cheng, Wei Du, Zhe Guan, Hai‐Li Lang, Hong‐Ji Liu, Jia Cao, Peng Chen, Jiang‐Hua Liu, Hui Xie, Chun‐Yuan Chen   +28 more
wiley   +1 more source

The role of public health networks in strengthening public health systems: the case of EMPHNET in the Eastern Mediterranean region

Frontiers in Public Health
The Eastern Mediterranean Region (EMR) faces a range of complex public health challenges, including endemic diseases, recurrent outbreaks, and weak health systems exacerbated by political instability and humanitarian crises. Public health networks play a
Yousef Khader, Dana Shalabi, Leen Daoud, Deema Al Bakri, Rana AlHamawi, Randa K. Saad, Sayed Himatt, Zeina Abdel Majeed, Ruba Kamal Alsouri, Nada Ahmed, Rabi Assaf, Nadine Haddad, Sardar Parwiz, Majd A. Alsoukhni, Haitham Bashier, Magid Al-Gunaid, Mohannad Al Nsour   +16 more
doaj   +1 more source

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

“Vaccinating a child is upon the woman”: implications for improving uptake for the recently introduced second dose of measles-containing vaccine based on a rapid community assessment in Uganda

Frontiers in Global Women's Health
BackgroundCaregiver barriers to accessing immunizations are a key factor influencing childhood vaccination. In preparation for the rollout of the second dose measles-containing vaccine (MCV2) in Uganda in October 2022, we aimed to identify possible ...
Adelline Twimukye, Nessa Ryan, Flavia Vivian Najjuma, Yvette Wibabara, Judith Nanyondo, Shillah Nakato, Maria Sarah Nabaggala, Ciara Sugerman, Daniel Kadobera, Rita Atugonza, John Kamulegeya, Joseph Magoola, Racheal Beyagira, Mohammed Lamorde, Alex Riolexus Ario, Alfred Driwale, Shibani Kulkarni   +16 more
doaj   +1 more source

Compliance with the vaccination schedule in children hospitalized with pneumonia and associated factors

Revista de Saúde Pública, 2018
OBJECTIVE: To verify the adequacy and factors associated with compliance with the immunization schedule (BCG, DTP-Hib, MMR, PCV-10) in children hospitalized with pneumonia at a pediatric referral hospital in Northeast Brazil.
Amanda Tabosa Pereira da Silva, Eduardo Jorge da Fonseca Lima, Maria de Fátima Costa Caminha, Andresa Tabosa Pereira da Silva, Edil de Albuquerque Rodrigues Filho, Carmina Silva dos Santos   +5 more
doaj   +1 more source