Results 151 to 160 of about 260,973 (300)

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Correction: α-Glycerol monolaurate promotes tight junction proteins expression through PKC/MAPK/ATF-2 signaling pathway

Frontiers in Nutrition
Siyu Dai, Cunjie Li, Dagang Li, Hong Wang   +3 more
doaj   +1 more source

Bridging the Gap Between Chemiluminescence Immunoassay and Liquid Chromatography-Tandem Mass Spectrometry for Infliximab Monitoring: Method Validation and Clinical Comparability Study. [PDF]

J Sep Sci
Xia Y, Zhu MM, Xiao MQ, Zhong CC, Zhou YJ, Xue YH, Zheng SW, Li L, Chen F.   +8 more
europepmc   +1 more source

Screening of bispecific antibodies during single cell cloning of recombinant Chinese hamster ovary cell lines to improve titer and product quality

Biotechnology Progress, EarlyView.
Abstract Development of therapeutic bispecific antibodies (BsAbs) poses significant manufacturability challenges associated with correct chain pairing and an increased diversity of impurities. Here we address this with a product quality assessment during cell line development (CLD), forgoing the need for genetic characterization during cell line ...
Molly Robinson, Jessica Willmott, Holly Corrigall, Daniela Lega, Joseph Stirling, Vithiya Vimalraj, Mitul Patel, Robyn Emmins   +7 more
wiley   +1 more source

Prediction of Acute Liver Injury Trajectory in Patients Following Acetaminophen Overdose: A Multibiomarker Machine Learning Proof‐of‐Concept Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical translation of novel therapies can be hindered by heterogeneity‐driven sample size inflation in late‐stage trials. In acetaminophen‐induced liver injury (APAP DILI), many patients recover spontaneously, diluting investigational drug efficacy signals.
Chris Humphries, Alastair M. Kilpatrick, Kathleen M. Scullion, Rhona Aird, Lorraine Bruce, Maria Elena Candela, Tak Yung Man, Stuart J. Forbes, James W. Dear   +8 more
wiley   +1 more source

A Novel Hemizygous <i>ANOS1</i> Variant in a Patient With Kallmann Syndrome and Type 2 Diabetes Mellitus: A Case Report. [PDF]

Case Rep Endocrinol
Qin S, Zhang Y, Chen Y, Chen W, Ni Y, Zhong J.   +5 more
europepmc   +1 more source

Non‐Invasive Estimation of Systemic Drug Exposure Using Exhaled Breath Metabolomics in Humans: A Translational Proof‐of‐Concept Study

Clinical Pharmacology &Therapeutics, EarlyView.
Accurate assessment of systemic drug exposure in humans remains challenging, as conventional approaches rely on intermittent blood sampling and laboratory‐based assays that are invasive and provide limited temporal resolution. Exhaled breath contains volatile and semi‐volatile compounds arising from drug metabolism and downstream biological processes ...
Kai Fricke, Diego M. Baur, Kapil Dev Singh, Felix Schmidt, Kathrin Müsch, Noriane A. Sievi, Marco Di Donato, Anton Schmick, Jonas Herth, Silvia Ulrich, Pablo Sinues, Marian Galovic, Malcolm Kohler   +12 more
wiley   +1 more source

Reliability of Point-of-Care Vitamin D Testing for Use in Primary Health Care: A Comparative Evaluation with Established CLIA Platforms. [PDF]

Int J Gen Med
Younes S, AlHamad T, Al-Louzi A, Al Khanji F, Ibrahim RM, Yaseen D, Al-Ansari R, Eltaweel A, Trad F, Nizamuddin PB, Zein N, Younes N, El Chaar D, Tang P, Al-Dewik N, Abu-Raddad LJ, Nasrallah GK.   +16 more
europepmc   +1 more source

Localized 3D acoustic streaming in microdroplets using high‐frequency micro‐beam IDTs

Droplet, EarlyView.
Miniaturized 160 MHz acoustic microbeam transducers, with a size much smaller than droplets, enable precise localized actuation, generating complex three‐dimensional streaming and tunable particle aggregation. This concept provides high‐resolution, non‐contact fluid manipulation for biosensing, lab‐on‐chip diagnostics, and targeted drug screening ...
D. Sánchez‐Saldaña, M. Fernandino, C.A. Dorao   +2 more
wiley   +1 more source

Elecsys pT181p immunoassay: Clinical performance for ruling out amyloid pathology. [PDF]

Alzheimers Dement (Amst)
Ritchie C, Hortsch S, Quijano-Rubio C, Menzel P, Kirste I, Caley D, Burke AD, Rowe CC, Suárez-Calvet M, Aarsland D, Liss J, Boada M, Watson D, Rapp M.   +13 more
europepmc   +1 more source