Results 171 to 180 of about 203,057 (268)

Computational Intelligence Accelerates CRISPR‐Cas‐Based Diagnostic Design

iLABMED, EarlyView.
Computational intelligence, including pangenome‐guided target mining, machine‐learning‐based guide RNA optimization, and autonomous AI agents, is shifting CRISPR diagnostic design from empirical screening to systematic, data‐driven engineering and accelerating the path from pathogen discovery to deployable diagnostics.
Hengyu Wang, Qiurun He, Xuhu Mao, Yong Sheng   +3 more
wiley   +1 more source

Evaluation of a research use only (RUO) TIMP-1 assay for use with the automated Alinity <i>i</i> platform. [PDF]

Biochem Biophys Rep
Anderson M, Grieshaber J, Ortiz J, Baclig M, Pacenti G, Munoz J, Rudolph C, Otis K, Corby J, Prostko J, Hemken P.   +10 more
europepmc   +1 more source

21-Deoxycortisone: A Novel Sensitive and Specific Newborn Screening Marker for Congenital Adrenal Hyperplasia. [PDF]

Int J Neonatal Screen
de Hora M, Heather N, Webster D, Albert BB, Hofman P.   +4 more
europepmc   +1 more source

Extreme Heterophilic Antibody Interference in BNP Immunoassay: A Case Report and Systematic Investigation Protocol

Journal of Clinical Laboratory Analysis, EarlyView.
A 53 year‐old male with type 2 diabetes presented extremely elevated BNP (> 4000 pg/mL) but normal NT‐proBNP and cardiac function. Systematic verification confirmed severe heterophilic antibody (HAMA) interference in the BNP chemiluminescence immunoassay.
Huicong Yang, Yuanhai Zheng, Zhenhua Zeng, Haimin Gao, Jinzhi Wu, Ayang Wu, Jie Lin   +6 more
wiley   +1 more source

Is urinary toxicology rapid screening a useful first-line diagnostic tool for paediatric coma in the emergency department? [PDF]

Front Pediatr
Malni I, Zupin L, Barbi E, Amaddeo A, Marin M.   +4 more
europepmc   +1 more source

Improving Linkage to the HCV Care Cascade in Nonspecialist Settings: Evaluation of the Performance and Triage Utility of the Elecsys HCV Duo Assay in Japan

Journal of Clinical Laboratory Analysis, EarlyView.
In nonspecialist departments, most anti‐HCV–positive individuals do not proceed to RNA testing. The Elecsys HCV Duo assay simultaneously detects anti‐HCV antibodies and core antigen from a single blood draw and preferentially identifies patients with clinically meaningful viral loads.
Hiroko Setoyama, Takehisa Watanabe, Shiho Miyase, Masakuni Tateyama, Motohiko Tanaka, Nobuhiro Minami, Masato Sasaki, Shunpei Hashigo, Kotaro Fukubayashi, Shotaro Ishii, Mutsuo Koga, Ryo Ichikawa, Hirofumi Iwashita, Yoshinari Sakai, Toshihiko Motohara, Kohei Tomita, Akinori Nakata, Yutaka Kai, Takeyasu Kounoe, Katsuki Haraoka, Takako Inoue, Takanori Suzuki, Kentaro Matsuura, Yasuhito Tanaka   +23 more
wiley   +1 more source

Rapid diagnostic tests, laboratory-based immunoassay and nucleic acid testing strategies for long-acting injectable pre-exposure prophylaxis: A systematic review and meta-analysis. [PDF]

PLoS Med
Tieosapjaroen W, Williams E, Johnson CC, Baptista Da Silva C, Barr-DiChiara M, Rodolph M, Ingold HL, Schmidt HA, Prochazka M, Msimanga B, Lastrucci C, Peralta H, Chitembo L, Andifasi P, Siegfried N, Landovitz RJ, Ong JJ.   +16 more
europepmc   +1 more source

Soluble B7‐H6 as a Novel Diagnostic Biomarker for Post‐Hepatitis B Cirrhosis: A Clinical Value Study

Journal of Clinical Laboratory Analysis, EarlyView.
This study investigates the potential of soluble B7‐H6 (sB7‐H6) as a novel diagnostic biomarker for post‐hepatitis B cirrhosis. The infographic visually presents the following key points: (1) Liver Disease Progression: Chronic hepatitis B (CHB) progresses to liver cirrhosis (LC), with serum sB7‐H6 levels increasing stepwise as the disease advances. (2)
Kaiyong Chen, Luxuan Yang, Huaiwu Fu, Lei Cao, Zhu Li   +4 more
wiley   +1 more source

Congenital Adrenal Hyperplasia in the Mediterranean: A Concise Overview. [PDF]

Pharmaceuticals (Basel)
Fanis P, Skordis N, Tomazou M, Phylactou LA, Neocleous V.   +4 more
europepmc   +1 more source

Changes of CEA Diagnostic Performance Under the New Reference Interval Stratified by Age and Sex

Journal of Clinical Laboratory Analysis, EarlyView.
Our study included patients with lung cancer, breast cancer, and colorectal cancer and apparently healthy individuals, conducted a large case–control study to assess the effects of age and sex on serum concentrations and positive rates of CEA, established age‐ and sex‐stratified reference intervals using indirect methods.
Ke Zhang, Xiarui Ye
wiley   +1 more source