This study established and validated comprehensive RIs for four key thrombus biomarkers (TAT, PIC, TM, and t‐PAIC) in a Chinese population using the Hoffmann and Bhattacharya indirect methods on a large clinical dataset. The tailored RIs offer a practical tool for early detection and risk assessment of thrombotic diseases, supporting more precise and ...
Lei Zhang +3 more
wiley +1 more source
Our work identifies a novel and significant association between low seminal levels of Human Epididymis Protein 4 (HE4) and the clinical condition of poor semen liquefaction, a common cause of male infertility. The findings are statistically robust, clinically relevant, and provide a foundational basis for future research into the mechanism by which HE4
Feifei Wang +5 more
wiley +1 more source
Development of a Competitive Chemiluminescent Enzyme Immunoassay Based on Recombinant FMDV VP2 Protein for Rapid and Simultaneous Detection of Antibodies Against Foot-and-Mouth Disease Virus Serotypes O and A. [PDF]
Bian S +7 more
europepmc +1 more source
Verification study enabled the detection of HIV false reactivity ranging from 0‐4% across rapid diagnostic tests. A reliable three‐tests algorithm ranked First Response HIV 1‐2‐0 Card, First Response HIV1+2/Syphilis Combo or STANDARD Q as suitable test 1 to mitigate false positive events. As countries move toward HIV elimination, implementing the three‐
Rogers Ajeh Awoh +34 more
wiley +1 more source
Measuring thyroid-stimulating hormone receptor antibodies using the IMMULITE<sup>®</sup> 2000 TSI assay is better than using the BRAHMS TRAK assay in an unselected clinical population, but both perform worse than expected: a real-world retrospective observational study. [PDF]
Manousou S +5 more
europepmc +1 more source
Pseudohypercalcemia induced by calcium‐binding monoclonal immunoglobulin in multiple myeloma is verified via laboratory assays and validated by therapeutic response. ABSTRACT Background Pseudohypercalcemia is easily misdiagnosed in clinical practice, potentially leading to unnecessary interventions.
Anjiang Zhao +3 more
wiley +1 more source
Spikes in the data: biological validation and applications of an assay for detecting faecal glucocorticoid metabolites in Western European hedgehogs (<i>Erinaceus europaeus</i>). [PDF]
Harper E +5 more
europepmc +1 more source
ABSTRACT The ability of organisms to effectively respond to challenges is critical for survival. We investigated how an acute stressor affected corticosterone, mitochondrial function, and DNA oxidative damage in a wild population of Leach's storm‐petrels (Hydrobates leucorhous).
Kayla E. Lichtner +10 more
wiley +1 more source
Clinical progress note: Rotavirus
Abstract Rotavirus is a vaccine‐preventable cause of acute, viral gastroenteritis typically characterized by diarrhea, vomiting, and fever. Prior to rotavirus vaccine introduction, nearly all children worldwide had been infected by 5 years of age. Severe rotavirus gastroenteritis causes dehydration and electrolyte derangements, and infants and young ...
Kelsey Thetford, Meghan Hofto
wiley +1 more source
Clinical Reclassification of Vitamin D Status Across Three Automated Immunoassays After Comparability Study. [PDF]
Huțanu A +5 more
europepmc +1 more source

