Results 271 to 280 of about 352,107 (336)

Targeting of a novel interplay between MET tyrosine kinase and NRF2 enhances sensitivity to Paclitaxel in triple negative breast cancer. [PDF]

J Exp Clin Cancer Res
Taddei I, Cirotti C, Lamballe F, Castellanet O, Maina F, Medici V, Fierro F, Corleone G, De Nicola F, Fanciulli M, Cesari E, Di Leone A, Piermattei A, Santoro A, Naro C, Sette C, Barilà D.   +16 more
europepmc   +1 more source

CD3ɛ Nanobody‐Engineered Extracellular Vesicles Driving In Vivo Generation of TCE‐secreting CAR‐Ts for Solid Tumor Therapy With Memory Response and Minimal Immunogenicity

Advanced Science, EarlyView.
HEK‐293T‐derived CD3ε Nb‐engineered EVs to generate dual‐targeting CAR‐T cells directly in vivo. These EVs selectively deliver CAR.BiTE transgenes into T cells and reprogramed to HLA‐G/PD‐L1‐targeting effector cells with enhanced memory and persistence.
Shi‐Wei Huang, Yu‐Chuan Lin, Chih‐Ming Pan, Yeh Chen, Ming‐You Shie, Cheng‐Yu Chen, Kai‐Wen Kan, Yi‐Wen Chen, Ming‐Chao Liu, Chung‐Chun Wu, Yu‐Ting Chiang, Huai‐Ping Ho, Chen‐Yu Lin, Pei‐Ying Lin, Yu‐Han Huang, Steffany Rusli, Wan‐Yu Mao, Pei‐Wen Huang, Sin‐Ting Wang, Wan‐Chen Tsai, Ya‐Hsu Chiu, Ting‐Hsun Lin, Wan‐Ling Chiang, Che‐Kai Chang, Zi‐Lun Lai, Mei‐Chih Chen, Shao‐Chih Chiu, Der‐Yang Cho   +27 more
wiley   +1 more source

Negative regulation of the NF-κB pathway by the ubiquitin ligase Nedd4-1(NE). [PDF]

Commun Biol
Persaud A, Kefalas G, Shteiman A, Priya A, Liang H, Melnyk RA, Astori A, Raught B, Rotin D.   +8 more
europepmc   +1 more source

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis

Advanced Science, EarlyView.
Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang, Yuchen Wang, Binbin Li, Xin Li, Chenyu Liu, Yanhao Chen, Cheng Tian, Dongmei Wang, Xiaosong Gu, Chunping Jiang, Yuda Wei, Qiurong Ding   +11 more
wiley   +1 more source

5-HT reuptake blockade induces pyroptosis in BRAF^V600E-mutated melanomas via remodeling histone serotonylation. [PDF]

Cell Rep Med
Li A, Xu S, Fan J, Liu J, Song X, Cao L, Gong Z, Lu X.   +7 more
europepmc   +1 more source

Pervasive phenotypic effects of FBXO42 are promoted by regulation of PP4 phosphatase. [PDF]

EMBO J
Yang H, Smith P, Ma Y, Southworth E, Gopala Krishna V, Salerno B, Rowland J, Loftus AEP, Grieco D, Vendrell I, Fischer R, Kessler BM, D'Angiolella V.   +12 more
europepmc   +1 more source

Single-cell analysis identifies BASP1 as a driver of drug resistance and cell plasticity in oral squamous cell carcinoma. [PDF]

J Biol Chem
Behera A, Datta S, Mohanty S, Mohapatra P, Ansari SA, Podder S, Rath R, Muduly DK, Swain RK, Raghav SK, Dash R.   +10 more
europepmc   +1 more source

RNASEH2C enhances TRAF3IP1 to degrade RAI14 in lysosomes thus hindering macrophage antigen presentation and advancing liver cancer. [PDF]

Cell Death Dis
Pan B, Yu H, Lin Z, Liu M, Liu J, Xu Y, Wu L, Zhang Q, Wang Z.   +8 more
europepmc   +1 more source

Epididymal macrophage senescence contributes to sperm motility decrease upon environmental stress. [PDF]

Sci Adv
Wang XR, Li H, Xiong YW, Yuan Z, Cheng XY, Hu YF, He XJ, Fan LL, Luo YX, Sun J, Sun CF, Zhang XX, Wang Y, Lu Q, Wang KW, Tan LL, Jiang XH, Zhu HL, Xu DX, Wang H.   +19 more
europepmc   +1 more source

Dietary sulfur amino acid restriction improves glucose homeostasis through hepatic de novo serine synthesis. [PDF]

Mol Metab
Ortega AF, Vang CM, Rome FI, Andreoni KM, Phoebe AM, Nelson AB, Crawford PA, Galligan JJ, Huang SC, Hughey CC.   +9 more
europepmc   +1 more source