Results 41 to 50 of about 4,533 (248)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Tracheobronchial Aspergillosis Mimicking Pseudotumoral Lesions in a Rare Presentation of a Known Disease

Clinical Case Reports
Tracheobronchial aspergillosis (TBA) is an uncommon form of invasive Aspergillus infection that can closely mimic endobronchial malignancy, particularly when presenting as an obstructive pseudotumoral lesion.
Cinthya Castillo Gamboa, Francisco Hernández Rodríguez, Yessika Medrano Hernández, Eduardo X. Porras Rosales   +3 more
doaj   +1 more source

Invited review: Piglet survival: benefits of the immunocompetence

Animal, 2019
Piglet mortality has a negative impact on animal welfare and public acceptance. Moreover, the number of weaned piglets per sow mainly determines the profitability of piglet production.
E.M. Heuß, M.J. Pröll-Cornelissen, C. Neuhoff, E. Tholen, C. Große-Brinkhaus   +4 more
doaj   +1 more source

Triazine Herbicide and NPK Fertilizer Exposure: Accumulation of Heavy Metals and Rare Earth Elements, Effects on Cuticle Melanization, and Immunocompetence in the Model Species Tenebrio molitor

Toxics, 2023
The increasing use of agrochemicals, including fertilizers and herbicides, has led to worrying metal contamination of soils and waters and raises serious questions about the effects of their transfer to different levels of the trophic web.
Attilio Naccarato, Maria Luigia Vommaro, Domenico Amico, Francesca Sprovieri, Nicola Pirrone, Antonio Tagarelli, Anita Giglio   +6 more
doaj   +1 more source

Effects of time spent in pregnancy or brooding on immunocompetence [PDF]

Sexes of a species may show different characteristics beyond the differences in their sexual organs and such sexual dimorphism often occurs in the level of immune response when exposed to pathogens (immunocompetence).
Eliassen, Sigrunn, Venkateswaran, V., Mangel, M., Revathi Venkateswaran, Vandana, Gokhale, C. ; https://orcid.org/, Gokhale, Chaitanya S., Eliassen, S., Mangel, Marc   +7 more
core   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Genetic covariance between indices of body condition and immunocompetence in a passerine bird

BMC Evolutionary Biology, 2005
Background Condition-dependence is a ubiquitous feature of animal life histories and has important implications for both natural and sexual selection. Mate choice, for instance, is typically based on condition-dependent signals.
Owens Ian PF, Blows Mark W, Gleeson Deborah J   +2 more
doaj   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Nasal Septal Abscess in an Immunocompetent Child

Pediatrics and Neonatology, 2012
Nasal septal abscess is defined as a collection of pus between the cartilage or the bony septum and the overlying mucoperichondrium or mucoperiostium. Appropriate management of a nasal septal abscess requires prompt diagnosis, adequate surgical drainage,
Yi-Chuan Huang, Pi-Lien Hung, Hsin-Ching Lin   +2 more
doaj   +1 more source