Results 61 to 70 of about 4,533 (248)
Advanced Science, EarlyView.In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu +12 more
wiley +1 more source
AGE, AUTOIMMUNITY, AND INFLAMMATION: THE CURIOUS CASE OF IMMUNOSENESCENCE AND INFLAMM-AGING
Anti-Aging Eastern Europe, 2022 An ever-aging population has caused an increase in the prevalence of diseases which occur in the elderly like diabetes and cancer; and autoimmune disease like rheumatoid arthritis (RA). On the other hand, ageing also causes an increased susceptibility to
T. G. Sundaram, Sakir Ahmed
doaj +1 more source
Does masculinity matter? The contribution of masculine face shape to male attractiveness in humans [PDF]
, 2010 Copyright: © 2010 Scott et al.Background: In many animals, exaggerated sex-typical male traits are preferred by females, and may be a signal of both past and current disease resistance.
Stephen, ID +18 more
core +2 more sources
Advanced Science, EarlyView.This study established a high‐quality organoid biobank derived from 68 tumor sites across 50 Chinese patients, elucidated the drug sensitivity‐based molecular subtyping in breast cancer, and revealed a novel mechanism of drug resistance mediated by the FAK‐ACSL1 pathway.
Hao Xu +10 more
wiley +1 more source
Cervical Transverse Myelitis After Chickenpox in An Immunocompetent Patient [PDF]
Acta Medica Iranica, 2010 Varicella-zoster viruses complications involving the CNS are estimated to occur rarely, transverse myelitis after Varicella-zoster virus in most patients is characterized by an abrupt onset of progressive weakness and sensory disturbance in the lower ...
Mehrnaz Rasoolinejad +3 more
doaj +1 more source
Frontiers in Animal ScienceThis study characterized the peripheral blood mononuclear cell (PBMC) transcriptomic responses to in vitro lipopolysaccharide (LPS) stimulation in beef steers with divergent residual average daily gain (RADG), a residual-based index of feed efficiency ...
Yarahy Leal +8 more
doaj +1 more source
Advanced Science, EarlyView.A supramolecular pyroptotic thermal switch encapsulates I3− within β‐cyclodextrin (β‐CD) and undergoes CaCO3 mineralization. Upon lysosomal acidification, CaCO3 is degraded, releasing Ca2+ and I3−. Concurrently, BODIPY activation converts I3− into I2, inducing oxidative stress and Ca2+ overload, which together trigger caspase‐3/GSDME‐mediated ...
Dan Wu +8 more
wiley +1 more source
Cytomegalovirus-induced Oral, Esophageal, Gastric and Colonic Ulcers in an Immunocompetent Patient
The Korean Journal of GastroenterologyCytomegalovirus (CMV) is a globally prevalent pathogen, with the gastrointestinal (GI) tract being one of the most frequently affected targets. On the other hand, the simultaneous involvement of multiple GI organs in immunocompetent individuals has ...
Seokin Kang, Nam-Hoon Kim
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대한영상의학회지, 2020 Invasive pulmonary aspergillosis (IPA) has been known to occur in immunocompromised patients, but has been rarely reported in immunocompetent patients. In immunocompetent patients, pulmonary fungal infections are not initially considered.
So-Hyun Ji +3 more
doaj +1 more source
Journal of Fungi, 2020 Juvenile hormone has been suggested to be a potential mediator in the trade-off between mating and insects’ immunity. Studies on various insect taxons have found that juvenile hormone interferes with humoral and cellular immunity. Although this was shown
Markus J. Rantala +5 more
doaj +1 more source