Results 51 to 60 of about 4,533 (248)

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Sexual dimorphism in immunocompetence: what does life-history theory predict?

, 2006
Sexual dimorphism in immunocompetence, usually in the direction of inferior male immunocompetence, has historically been explained as the result of proximate physiological mechanisms such as the immunosuppressive effects of the male hormone testosterone.
Kokko, H., Andrew M. Stoehr, Hanna Kokko
core   +1 more source

A tradeoff between immunocompetence and sexual ornamentation in domestic fowl [PDF]

, 1999
Females often select their mates on the basis of the size or intensity of sexual ornaments, and it is thought that such traits are reliable indicators of male quality because the costliness of these traits prevents cheating. The immunocompetence handicap
Dieleman, SJ, Parmentier, HK, Verhulst, S.; id_orcid, Verhulst, S., Parmentier, H.K., Dieleman, S.J., Verhulst, S.,, Parmentier, H.K.,, Verhulst, S, Dieleman, S.J.,   +9 more
core   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Impact of induction agents and maintenance immunosuppression on torque teno virus loads and year-one complications after kidney transplantation

Frontiers in Immunology
BackgroundTorque teno virus load (TTVL) is gaining importance as a surrogate parameter to assess immunocompetence in kidney transplant recipients. Although the dynamics of TTVL have been investigated before, the impact of different induction agents and ...
Marvin Reineke, Claudius Speer, Claudius Speer, Christian Bundschuh, Julian A. F. Klein, Lisa Loi, Claudia Sommerer, Claudia Sommerer, Martin Zeier, Paul Schnitzler, Paul Schnitzler, Christian Morath, Christian Morath, Louise Benning   +13 more
doaj   +1 more source

Direct and Correlated Responses to Multitrait, Divergent Selection for Immunocompetence [PDF]

, 1994
Leghorn lines had been selected for an immunocompetence index based on four traits: antibody production to Mycoplasma gallisepticum (MG) and Pasteurella multocida (PM) vaccines, reticuloendothelial clearance of colloidal carbon (CCA), and cell-mediated ...
Freeman, A. E., R.P. KEAN, A. CAHANER, S.J. LAMONT, Kean, R. P., A.E. FREEMAN, Cahaner, A., Lamont, Susan   +7 more
core   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Aspergillus flavus-Induced Brain Abscess in an Immunocompetent Child : Case report

Sultan Qaboos University Medical Journal, 2016
Intracranial aspergillosis is an extremely rare manifestation of invasive aspergillosis in immunocompetent children and is associated with high morbidity and mortality.
Nawal Al-Maskari, Ibrahim Hussain, Suleiman Jumaa, Essam A. Al-Shail   +3 more
doaj   +1 more source

Pulmonary Malakoplakia Associated with Peripheral Cysts in an Immunocompetent Patient: A Case Report

Journal of Chest Surgery, 2022
Pulmonary malakoplakia is a rare lung lesion more frequently found in immunocompromised patients than in immunocompetent individuals. In this study, we report the challenging case of a young immunocompetent patient with an irregular pulmonary nodule ...
Liana Ferreira Corrêa, Thiago Krieger Bento da Silva, Spencer Marcantonio Camargo, Bianca Canela Furian   +3 more
doaj   +1 more source

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age‐Related Declines in Humoral and Cellular Immunity Relative to Shingrix

Advanced Science, EarlyView.
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song, Jerry Yan, Ben S. Ou, Olivia M. Saouaf, Noah Eckman, E. A. Appel   +5 more
wiley   +1 more source