Results 71 to 80 of about 131,504 (305)

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

open access: yesAdvanced Science, EarlyView.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo   +16 more
wiley   +1 more source

Multiple cutaneous swellings in an immunocompetent host – cryptococcosis overlooked [PDF]

open access: yes, 2011
Recently, there has been an increase in the incidence of cryptococcosis even among immunocompetent patients. We present a case of multiple subcutaneous swellings later developing into a non-healing ulcer caused by Cryptococcus in a 60 year-old ...
Yagain, Kiran   +4 more
core   +1 more source

Granulomatous Hepatitis Secondary to Histoplasmosis in an Immunocompetent Patient [PDF]

open access: yes, 2021
Histoplasma capsulatum is the most common endemic mycosis in the United States and usually occurs in certain geographic areas, such as the Mississippi or Ohio River valleys.
Nimri, Faisal M   +4 more
core   +1 more source

Longitudinal Single‐Axon‐Resolution Imaging of Peripheral Nerve Injury Response in Mice Using an Optical Window Implant

open access: yesAdvanced Science, EarlyView.
A minimally invasive optical window enables stable, long‐term imaging of peripheral nerves in vivo at single‐axon resolution. Dynamic processes of degeneration, regeneration, and cellular remodeling are visualized across multiple time scales within the same nerve region, providing a unique platform to study a variety of anatomical and molecular events ...
Igor D. Luzhansky   +15 more
wiley   +1 more source

Mycobacterium chelonae Wrist Infection in an Immunocompetent Patient

open access: yesJournal of Orthopaedics, Trauma and Rehabilitation, 2016
We report a 48-year-old Chinese immunocompetent female who presented with right wrist pain and swelling for 9 months because of Mycobacterium chelonae infection of her right wrist. M. chelonae infection has been increasingly reported.
Ka-Ki Tam, Wai-Yin Mak, Tak-Chuen Wong
doaj   +1 more source

Cutaneous mucormycosis with necrotising fasciitis in a young immunocompetent individual

open access: yes, 2011
Primary cutaneous mucormycosis is uncommon and is extremely rare in immunocompetent young individuals. Here we report a case of necrotising fasciitis due to mucormycosis in an immunocompetent young individual following minor trauma. Mucormycosis must be
Chakrapani Mahabala   +4 more
core   +1 more source

Listeria monocytogenes meningitis in an immunocompetent adult: a case report [PDF]

open access: yes, 2012
Listeria monocytogenes (L. monocytogenes) is an uncommon cause of bacterial meningitis in immunocompetent adults. Patients with immunosuppression are at increased risk of developing serious invasive diseases, particularly meningitis.
Zheng-Hao Tang   +3 more
core   +1 more source

Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

open access: yesAdvanced Science, EarlyView.
Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta   +10 more
wiley   +1 more source

Invasive Aspergillosis After Non-Fatal Drowning

open access: yesInternational Medical Case Reports Journal, 2020
Shunichi Koide,1 Yoshiro Hadano,2,3 Shinji Mizuochi,4 Hitoshi Koga,1 Hisashi Yamashita1 1Department of Emergency Medicine, St. Mary’s Hospital, Kurume, Japan; 2Department of Infection Control and Prevention, Tokyo Medical and Dental University ...
Koide S   +4 more
doaj  

Mild toxic anterior segment syndrome mimicking delayed onset toxic anterior segment syndrome after cataract surgery

open access: yesIndian Journal of Ophthalmology, 2014
Toxic anterior segment syndrome (TASS) is an acute sterile postoperative anterior segment inflammation that may occur after anterior segment surgery. I report herein a case that developed mild TASS in one eye after bilateral uneventful cataract surgery ...
Su-Na Lee
doaj   +1 more source

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