Results 81 to 90 of about 131,504 (305)
RECEPTORS ON IMMUNOCOMPETENT CELLS [PDF]
The Journal of Experimental Medicine, 1970 During the course of the immune response to dinitrophenylated guinea pig albumin (DNP-GPA), a striking and parallel increase in avidity for ϵ-DNP-L-lysine occurs in the receptors on antigen-binding lymphocytes, antibody secreted by individual plaque-forming cells, and serum antibody molecules. A detailed analysis of the avidity distribution of antibody
J M, Davie, W E, Paul
openaire +6 more sources
Outline of transfer experiments performed in nude and immunocompetent rats.
, 2015 Biopsy tissue from GBM patients or passaged xenograft tumors were minced into cubes and allowed to form spheroids in agar-overlay cultures before transplanting to the brain of animals.
Karl A. Brokstad (785520) +5 more
core +1 more source
Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy
Advanced Science, EarlyView.A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li +11 more
wiley +1 more source
, 2014 Cat-scratch disease (CSD) is the most frequent presentation of Bartonella henselae infection. It has a worldwide distribution and is associated with a previous history of scratch or bite from a cat or dog.
Oteo, José A. +5 more
core +1 more source
Advanced Science, EarlyView.A biomimetic GOx/Arg‐loaded nanoplatform produces nitric oxide through an in situ catalytic cascade reaction, enabling dual‐target metabolic regulation in diabetes‐associated biofilm infections. Bacterial metabolism is disrupted, and macrophage immunometabolism is reprogrammed, resulting in biofilm eradication, immune restoration, and enhanced ...
Mingzhang Li +13 more
wiley +1 more source
Journal of Community Hospital Internal Medicine Perspectives, 2018 CMV can infect a variety of organs including gastrointestinal tract, meninges, eyes and other organs depending upon the nature of immune system but it can also manifest as a flare-up in ulcerative colitis patients.
Mustafa Dawood +2 more
doaj +1 more source
CMV in the gut: a critical review of CMV detection in the immunocompetent host with colitis. [PDF]
, 2015 As scientific techniques for the detection of cytomegalovirus (CMV) improve, we are able to detect small amounts of CMV in the mucosal wall. As clinicians, we are unsure how to interpret the results of this novel test.
Webster, DP +4 more
core
Advanced Science, EarlyView.Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song +5 more
wiley +1 more source
Therapeutics and Clinical Risk Management, 2017 Puo-Hsien Le,1,2 Wey-Ran Lin,1,3 Chia-Jung Kuo,1–3 Ren-Chin Wu,3,4 Jun-Te Hsu,3,5 Ming-Yao Su,1–3 Chun-Jung Lin,1 Cheng-Tang Chiu1–3 1Department of Gastroenterology and Hepatology, Linkou Chang Gung Memorial Hospital, 2Taiwan ...
Le PH +7 more
doaj
Advanced Science, EarlyView.In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu +12 more
wiley +1 more source