Results 81 to 90 of about 60,494 (308)

TriCON: A Carbon‐Based Triple‐Modal Nanoplatform for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
We developed TriCON, a triple‐modality nanotherapeutic platform, to treat pancreatic ductal adenocarcinoma (PDAC) by synergizing gene editing, chemotherapy, and immunotherapy. TriCON utilizes CRISPR/Cas9 to target the poliovirus receptor (PVR), combined with nano‐encapsulated doxorubicin and checkpoint blockade. This approach achieved significant tumor
Xinyu Peng, Jiaxing Huang, Shengnan Lv, Jian Zhang, Liangliang Zhang, Huan Liu, Yan Liu, Zhen‐An Qiao, Feng Wei, Bao‐Lian Su   +9 more
wiley   +1 more source

ITGB1 Regulates Triple‐Negative Breast Cancer Development by Modulating the Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumorigenesis and metastasis are frequently attributed to the intricate interplay between cancer cells and the tumor microenvironment (TME). Comprehending the mechanisms and key regulators of cancer‐immune crosstalk in the TME is imperative for developing efficacious immunotherapy.
Nuozi Song, Siqi Chen, Lei Wang, Jessica Dang, Xu Cao, Stephanie Singh, Lu Yang, Jinhui Wang, Steven T. Rosen, Yingyu Wang, Chun‐Wei D. Chen, Cheng Zhang, Mingye Feng   +12 more
wiley   +1 more source

HPV vaccination of immunocompromised hosts. [PDF]

, 2017
It is well-established that immunocompromised people are at increased risk of HPV-related disease compared with those who are immunocompetent. Prophylactic HPV sub-unit vaccines are safe and immunogenic in immunocompromised people and it is strongly ...
Bhatla, N, Brotherton, JML, de Sanjosé, S, Garland, SM, IPVS, Kaufmann, AM, Moscicki, AB, Palefsky, JM, Sankaranarayanan, R, Stanley, M   +9 more
core   +3 more sources

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
ABSTRACT While the function of biglycan (BGN) is recognized in various cancers, its precise role and the mechanisms underlying cancer‐associated fibroblasts (CAFs) formation within the melanoma tumor microenvironment (TME) remain poorly understood. Utilizing spatial transcriptomics, single‐cell RNA sequencing (scRNA‐seq), vitro/vivo assays, function ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

Primary Tonsillar Tuberculosis: Is it Really a Rare Entity?

Erciyes Medical Journal, 2020
Background: Oropharyngeal tuberculosis (TB), including tonsillar TB, is rare in an immunocompetent adult. Tonsillar TB is more likely to occur as a result of pulmonary TB causing secondary inoculation of tubercle bacilli. The primary form of tonsillar TB
Vinota Paniselvam, Chee Chean Lim, Fong Juen Kiew, Gagandeep Mann   +3 more
doaj   +1 more source

Epidemiology and potential preventative measures for viral infections in children with malignancy and those undergoing hematopoietic cell transplantation. [PDF]

, 2012
In pediatric patients with malignancy and those receiving hematopoietic stem cell transplants, bacterial and fungal infections have been the focus of fever and neutropenia episodes for decades.
Alexander, Sarah, Dvorak, Christopher C, Fisher, Brian T, Sung, Lillian, Zaoutis, Theoklis E, Zerr, Danielle M   +5 more
core   +1 more source

Logic‐Gated HSV‐TK/GCV Suicide Gene Circuit for Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
The BRAS comprises two modular genetic components driven by distinct tumor‐specific promoters and a failsafe layer with the NOT gate. This multi‐input logic gate circuit enables precise, specific expression of HSV‐TK in breast cancer cells with hardly expression in normal cell and effectively inhibits tumor growth in a triple‐negative breast cancer ...
Shasha Tang, Yuan Fang, Lingli Jin, Dongyang Liu, Yicheng Liu, Ruijia Zheng, Liyun Yong, Xin Wu, Longliang Qiao, Meiyan Wang, Fengfeng Cai   +10 more
wiley   +1 more source

Clinical case of parvovirus B19 infection in adult immunocompetent patient

Aktualʹnaâ Infektologiâ, 2018
A clinical case of parvovirus B19 infection is described. The published data on the development of parvovirus B19 infection in immunocompetent adult patients were analyzed in this article.
O.V. Markevych, O.V. Piddubna, V.O. Kuzmina   +2 more
doaj   +1 more source

Female Scent Signals Enhances Male Resistance to Influenza [PDF]

, 2009
Scent of receptive females as signal to reproduction stimulate male mice to olfactory search of a potential breeding partner^1, 2^. This searching behavior is coupled with infection risk due to bacterial contamination of the fecal and urine scent marks^4^
Alla M. Zaidman, Ekaterina A. Litvinova, Elena P. Goncharova, Marina A. Zenkova, Mikhail P. Moshkin   +4 more
core   +1 more source

Hemolytic anemia due to acute cytomegalovirus infection in an immunocompetent adult: a case report and review of the literature [PDF]

, 2010
Introduction Cytomegalovirus is a common virus responsible for a wide range of clinical manifestations. Hemolysis is a rare but potentially life-threatening complication of cytomegalovirus infection, described mostly in immunocompromised patients, the ...
Fabrizio Taglietti, Cecilia M Drapeau, Elisabetta Grilli, Alessandro Capone, Pasquale Noto, Simone Topino, Nicola Petrosillo   +6 more
core   +1 more source